Gender
Item
male and female subjects
boolean
C0079399 (UMLS CUI [1])
Age
Item
aged 18 to 55 years
boolean
C0001779 (UMLS CUI [1])
Female Sterilization | Menopause | Contraceptive methods | Childbearing Potential pregnancy blood test Negative | Childbearing Potential Urine pregnancy test negative
Item
for female subjects, surgically sterile or at least 2 years menopausal, or using an acceptable method of birth control. if of childbearing potential, have a documented negative blood or urine pregnancy test within 24 hours prior to dosing.
boolean
C0015787 (UMLS CUI [1])
C0025320 (UMLS CUI [2])
C0700589 (UMLS CUI [3])
C3831118 (UMLS CUI [4,1])
C0850355 (UMLS CUI [4,2])
C0205160 (UMLS CUI [4,3])
C3831118 (UMLS CUI [5,1])
C0430057 (UMLS CUI [5,2])
Laboratory Procedures | Upper Limit of Normal | Clinical Significance
Item
clinical laboratory values <2 times upper limit of normal (uln) or deemed not clinically significant by the investigator
boolean
C0022885 (UMLS CUI [1])
C1519815 (UMLS CUI [2])
C2826293 (UMLS CUI [3])
Compliance behavior Study Protocol | Informed Consent
Item
ability to understand the requirements of the study, provide written informed consent, abide by the study restrictions, and agree to return for the required assessments
boolean
C1321605 (UMLS CUI [1,1])
C2348563 (UMLS CUI [1,2])
C0021430 (UMLS CUI [2])
HIV Infections | Hepatitis | Communicable Diseases
Item
human immunodeficiency virus (hiv) infection, or hepatitis or other ongoing infectious disease.
boolean
C0019693 (UMLS CUI [1])
C0019158 (UMLS CUI [2])
C0009450 (UMLS CUI [3])
Alcohol abuse | Beer | Wine | Spirits
Item
current evidence of alcohol abuse (greater than 4 units of alcohol on most days; 1 unit = 1/2 pint of beer, 1 glass of wine or 1 oz. of spirits), or in the option of the investigator that subject may be alcoholic.
boolean
C0085762 (UMLS CUI [1])
C2107808 (UMLS CUI [2])
C2203276 (UMLS CUI [3])
C0301611 (UMLS CUI [4])
Substance Use Disorders DSM-IV
Item
current abuse of illicit substances, using the diagnostic and statistical manual (dsm) iv definition of drug abuse.
boolean
C0038586 (UMLS CUI [1,1])
C0220952 (UMLS CUI [1,2])
Current Smoker | Tobacco use
Item
current smoker or use of other tobacco products.
boolean
C3241966 (UMLS CUI [1])
C0543414 (UMLS CUI [2])
Pregnancy | Pregnancy, Planned | Breast Feeding
Item
currently pregnant, planning to become pregnant during the course of the study, or nursing mother.
boolean
C0032961 (UMLS CUI [1])
C0032992 (UMLS CUI [2])
C0006147 (UMLS CUI [3])
Diabetes Mellitus, Insulin-Dependent | Diabetes Mellitus, Non-Insulin-Dependent
Item
type i or type ii diabetes.
boolean
C0011854 (UMLS CUI [1])
C0011860 (UMLS CUI [2])
Malignant Neoplasms | Basal cell carcinoma | Squamous cell carcinoma of skin | Carcinoma in situ of uterine cervix
Item
malignancy in the last 5 years, with the exception of nonmetastatic basal cell or squamous cell carcinoma of the skin or localized carcinoma in situ of the cervix.
boolean
C0006826 (UMLS CUI [1])
C0007117 (UMLS CUI [2])
C0553723 (UMLS CUI [3])
C0851140 (UMLS CUI [4])
Take prescription medications | Take non-prescription medications | Phytotherapy
Item
currently taking prescription or over-the-counter medications including herbal therapies, within 14 days of enrollment into the study.
boolean
C3843193 (UMLS CUI [1])
C3843194 (UMLS CUI [2])
C0242388 (UMLS CUI [3])
Hypersensitivity N-Methyl-D-Aspartate Receptors Ligands | Intolerance to N-Methyl-D-Aspartate Receptors Ligands | Ketamine | Dextromethorphan | Memantine | Methadone | Propoxyphene | ketobemidone
Item
history of allergy, sensitivity, or intolerance to nmdar ligands including ketamine, dextromethorphan, memantine, methadone, dextropropoxyphene, or ketobemidone or concomitant use of such agents.
boolean
C0020517 (UMLS CUI [1,1])
C0080093 (UMLS CUI [1,2])
C0023688 (UMLS CUI [1,3])
C1744706 (UMLS CUI [2,1])
C0080093 (UMLS CUI [2,2])
C0023688 (UMLS CUI [2,3])
C0022614 (UMLS CUI [3])
C0011816 (UMLS CUI [4])
C0025242 (UMLS CUI [5])
C0025605 (UMLS CUI [6])
C0033493 (UMLS CUI [7])
C0064311 (UMLS CUI [8])
Investigational New Drugs Other | Investigational Medical Device Other
Item
received another investigational drug or device within 30 days of enrollment in this study.
boolean
C0013230 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C2346570 (UMLS CUI [2,1])
C0205394 (UMLS CUI [2,2])
Study Subject Participation Status
Item
previously participated in this study.
boolean
C2348568 (UMLS CUI [1])
Mental disorders | Major Depressive Disorder | Bipolar Disorder | Anxiety | Schizophrenia | Medical condition Interferes with Drug Evaluation | Renal Insufficiency Severe | Hepatic impairment Severe | Liver diseases Severe | Medical condition Study Subject Participation Status Limited
Item
psychiatric disease including major depression, bipolar disorder, anxiety, or schizophrenia, or other medical condition that, in the opinion of the investigator, would interfere with the evaluation of the study drug safety. 13) in the option of the investigator or the sponsor's study monitor, has a history of severe renal or hepatic impairment, severe active hepatic disease, or other clinically significant medical condition that may preclude safe study participation.
boolean
C0004936 (UMLS CUI [1])
C1269683 (UMLS CUI [2])
C0005586 (UMLS CUI [3])
C0003467 (UMLS CUI [4])
C0036341 (UMLS CUI [5])
C1699700 (UMLS CUI [6,1])
C0521102 (UMLS CUI [6,2])
C0013175 (UMLS CUI [6,3])
C1565489 (UMLS CUI [7,1])
C0205082 (UMLS CUI [7,2])
C0948807 (UMLS CUI [8,1])
C0205082 (UMLS CUI [8,2])
C0023895 (UMLS CUI [9,1])
C0205082 (UMLS CUI [9,2])
C1699700 (UMLS CUI [10,1])
C2348568 (UMLS CUI [10,2])
C0439801 (UMLS CUI [10,3])