age
Item
men & women ≥18 years of age
boolean
C0001779 (UMLS CUI [1])
renal cell carcinoma
Item
histologic confirmation of renal cell carcinoma (rcc) with clear-cell component
boolean
C0007134 (UMLS CUI [1])
Metastatic Renal Cell Cancer
Item
advanced/metastatic rcc
boolean
C0278678 (UMLS CUI [1])
measurable disease
Item
measurable disease per response evaluation criteria in solid tumors (recist) 1.1 criteria
boolean
C1513041 (UMLS CUI [1])
anti-angiogenic therapy
Item
received 1 or 2 prior anti-angiogenic therapy regimens in advanced or metastatic setting
boolean
C0596087 (UMLS CUI [1])
karnofsky performance score
Item
karnofsky performance score ≥70%
boolean
C0206065 (UMLS CUI [1])
central nervous system (cns) metastases
Item
any central nervous system (cns) metastases or history of cns metastases
boolean
C0279130 (UMLS CUI [1])
Sirolimus
Item
prior therapy with an mammalian target of rapamycin (mtor) inhibitor
boolean
C0072980 (UMLS CUI [1])
autoimmune disease
Item
any active known or suspected autoimmune disease
boolean
C0004364 (UMLS CUI [1])
adrenal insufficiency
Item
uncontrolled adrenal insufficiency
boolean
C1963059 (UMLS CUI [1])
chronic liver disease
Item
active chronic liver disease
boolean
C0341439 (UMLS CUI [1])
Malignant Neoplasms
Item
prior malignancy active within past 3 years, except for locally curable cancers
boolean
C0006826 (UMLS CUI [1])