mild to moderate essential hypertension
Item
diagnosis of mild to moderate essential hypertension (sitting diastolic blood pressure >= 90 and < 110 and/or sitting systolic blood pressure >= 140 and < 180)
boolean
C0085580 (UMLS CUI [1,1])
C1299392 (UMLS CUI [1,2])
obesity
Item
diagnosis of obesity (body mass index >= 27 and < 50 and steady body weight)
boolean
C0028754 (UMLS CUI [1])
postmenopausal or contraceptive use
Item
female patients must be postmenopausal for at least 1 year, surgically incapable of childbearing, practicing abstinence, or practicing an acceptable method of contraception (requires negative pregnancy test)
boolean
C0232970 (UMLS CUI [1])
C1999124 (UMLS CUI [2])
hypersensitivity to topiramate
Item
prior exposure or known contraindication or hypersensitivity to topiramate
boolean
C1301624 (UMLS CUI [1,1])
C0076829 (UMLS CUI [1,2])
C0020517 (UMLS CUI [1,3])
pregnant or nursing women
Item
pregnancy, nursing or subjects who plan to become pregnant during the study
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
severe hypertension
Item
diagnosis of severe hypertension
boolean
C0020538 (UMLS CUI [1])
diabetes mellitus
Item
history or diagnosis of diabetes mellitus
boolean
C0011849 (UMLS CUI [1])
hypertension secondary
Item
a history of diastolic or systolic hypertension secondary to a known cause
boolean
C0155616 (UMLS CUI [1])
cardiovascular or liver disease
Item
significant cardiovascular or liver disease
boolean
C0007222 (UMLS CUI [1])
C0023895 (UMLS CUI [2])