Parkinson Disease | Age
Item
idiopathic parkinson's disease (pd) diagnosed between the ages of 30 and 80 years;
boolean
C0030567 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Hoehn and Yahr grades
Item
hoehn and yahr stage 1-3 in an "on" state;
boolean
C0451215 (UMLS CUI [1])
Levodopa Medication regimen Waking Required
Item
require levodopa-containing medication regimen at least 4 times during the waking day;
boolean
C0023570 (UMLS CUI [1,1])
C0237125 (UMLS CUI [1,2])
C0442696 (UMLS CUI [1,3])
C1514873 (UMLS CUI [1,4])
Motor fluctuations Waking | Levodopa Responsiveness
Item
experience motor fluctuations with a minimum of 2 hours of average daily "off" time per waking day (excluding early morning "off" time) and demonstrate levodopa responsiveness;
boolean
C1868976 (UMLS CUI [1,1])
C0442696 (UMLS CUI [1,2])
C0023570 (UMLS CUI [2,1])
C0552602 (UMLS CUI [2,2])
Parkinson Disease Medication regimen Stable
Item
are on stable pd medication regimen;
boolean
C0030567 (UMLS CUI [1,1])
C0237125 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
Levodopa Daily Dose
Item
total daily levodopa (ld) dose <1600 mg/day;
boolean
C0023570 (UMLS CUI [1,1])
C2348070 (UMLS CUI [1,2])
Spirometry Ability
Item
able to perform a spirometry maneuver in the on and off states
boolean
C0037981 (UMLS CUI [1,1])
C0085732 (UMLS CUI [1,2])
Actual Effective Cognition mini-mental status exam score
Item
normal cognition confirmed by mini mental state examination (mmse) score ≥25 ;
boolean
C2712133 (UMLS CUI [1,1])
C2225229 (UMLS CUI [1,2])
Pregnancy | Breast Feeding
Item
pregnant or lactating females;
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Parkinson Disease H/O: surgery | Stereotactic surgery Planned
Item
previous surgery for pd or plan to have stereotactic surgery during the study period;
boolean
C0030567 (UMLS CUI [1,1])
C0455610 (UMLS CUI [1,2])
C1735594 (UMLS CUI [2,1])
C1301732 (UMLS CUI [2,2])
Psychotic symptom Requirement Therapeutic procedure | Suicide ideation | Suicide attempt
Item
history of psychotic symptoms requiring treatment, or suicide ideation or attempt within last year;
boolean
C0871189 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0087111 (UMLS CUI [1,3])
C1821181 (UMLS CUI [2])
C0038663 (UMLS CUI [3])
Medical contraindication Levodopa
Item
known contraindication to the use of levodopa;
boolean
C1301624 (UMLS CUI [1,1])
C0023570 (UMLS CUI [1,2])
Comorbidity Study Subject Participation Status Limited | Comorbidity At risk patient safety
Item
any significant condition, severe concurrent disease, abnormality or finding that would make patients unsuitable or may compromise patient safety;
boolean
C0009488 (UMLS CUI [1,1])
C2348568 (UMLS CUI [1,2])
C0439801 (UMLS CUI [1,3])
C0009488 (UMLS CUI [2,1])
C1444641 (UMLS CUI [2,2])
C1113679 (UMLS CUI [2,3])
Medical contraindication Spirometry
Item
any any contraindication to performing routine spirometry.
boolean
C1301624 (UMLS CUI [1,1])
C0037981 (UMLS CUI [1,2])