Gender | Age | Informed Consent | Non-smoker
Item
male between 40 and 65 years at the time of signing the informed consent non-smoker
boolean
C0079399 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
C0021430 (UMLS CUI [3])
C0337672 (UMLS CUI [4])
Compliance behavior | Life Style Restriction
Item
willing to comply with protocol and lifestyle restrictions
boolean
C1321605 (UMLS CUI [1])
C0023676 (UMLS CUI [2,1])
C0443288 (UMLS CUI [2,2])
Language comprehension Excellent English Language Questionnaires
Item
excellent understanding of english (for questionnaires)
boolean
C0233733 (UMLS CUI [1,1])
C1551022 (UMLS CUI [1,2])
C0376245 (UMLS CUI [1,3])
C0034394 (UMLS CUI [1,4])
Outpatient Capability Positron-Emission Tomography
Item
subject is ambulant and capable of attending a pet scan visit as an outpatient.
boolean
C0029921 (UMLS CUI [1,1])
C2698977 (UMLS CUI [1,2])
C0032743 (UMLS CUI [1,3])
Childbearing Potential Contraceptive methods | Positron-Emission Tomography | follow-up
Item
subjects with female partners of child-bearing potential must agree to use one of the contraception methods permitted by the study. this criterion must be followed from after the first pet scan until after the follow-up contact.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0032743 (UMLS CUI [2])
C1522577 (UMLS CUI [3])
Collateral Circulation Entire radial artery Entire ulnar artery Both hands | Allen test
Item
adequate collateral flow to the radial and ulnar arteries in both hands as determined by an allen's test.
boolean
C0009348 (UMLS CUI [1,1])
C1278948 (UMLS CUI [1,2])
C1278949 (UMLS CUI [1,3])
C0230377 (UMLS CUI [1,4])
C0231664 (UMLS CUI [2])
Body Weight
Item
body weight ≥50 kg.
boolean
C0005910 (UMLS CUI [1])
Healthy Volunteers | Medical History Family history | Physical Examination | Monitor vital signs, respiratory and circulatory adequacy, response to anesthesia, and other physiological parameters; measure and evaluate appropriate lab values | Laboratory studies
Item
healthy subjects are defined as individuals who are free from clinically significant illness or disease as determined by their medical history (including family), physical examination, objective physiological measures, previous laboratory studies, and other tests.
boolean
C1708335 (UMLS CUI [1])
C0262926 (UMLS CUI [2,1])
C0241889 (UMLS CUI [2,2])
C0031809 (UMLS CUI [3])
C0513833 (UMLS CUI [4])
C0681827 (UMLS CUI [5])
Assessment: Cognition
Item
successful completion of the camcog.
boolean
C0870300 (UMLS CUI [1])
Mental disorders Major
Item
current or past history of major psychiatric disorder
boolean
C0004936 (UMLS CUI [1,1])
C0205164 (UMLS CUI [1,2])
Substance Use Disorders
Item
current or past history of substance use disorder
boolean
C0038586 (UMLS CUI [1])
ID.12
Item
clinically significant brain injury or abnormality
boolean
C0270611 (UMLS CUI [1])
C4021085 (UMLS CUI [2])
Liver diseases | Biliary tract abnormality | Gilbert Disease | Biliary calculi Asymptomatic
Item
current or chronic history of liver disease, or known hepatic or biliary abnormalities (with the exception of gilbert's syndrome or asymptomatic gallstones).
boolean
C0023895 (UMLS CUI [1])
C0023895 (UMLS CUI [2])
C0549613 (UMLS CUI [3])
C0017551 (UMLS CUI [4])
C0242216 (UMLS CUI [5,1])
C0231221 (UMLS CUI [5,2])
Claustrophobia | Unable to lie down Scanning Systems, Computed Tomography/Positron Emission Tomography
Item
history of or suffers from claustrophobia or subject feels unable to lie flat and still on their back for a period of up to 2 hours in the pet/ct scanner.
boolean
C0008909 (UMLS CUI [1])
C0560842 (UMLS CUI [2,1])
C1139717 (UMLS CUI [2,2])
Study Subject Participation Status | Nuclear medicine procedure | Positron-Emission Tomography | Radiology studies | Occupational Exposure Exposure to radiation
Item
previous inclusion in a research and/or medical protocol involving nuclear medicine, pet or radiological investigations or occupational exposure resulting in radiation exposure greater than 10 msv over the past 3 years or greater than 10 msv in a single year including the proposed study. clinical exposure from which the subject receives a direct benefit is not included in these calculations.
boolean
C2348568 (UMLS CUI [1])
C0203634 (UMLS CUI [2])
C0032743 (UMLS CUI [3])
C0807679 (UMLS CUI [4])
C0028798 (UMLS CUI [5,1])
C0015333 (UMLS CUI [5,2])
Study Subject Participation Status Involvement with Investigational New Drugs
Item
previous inclusion in a research and/or medical protocol involving study medication within the last 3 months
boolean
C2348568 (UMLS CUI [1,1])
C1314939 (UMLS CUI [1,2])
C0013230 (UMLS CUI [1,3])
Compliance behavior Limited
Item
in the opinion of the study team they are unlikely to comply with the study protocol and restrictions that it imposes.
boolean
C1321605 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
Medical contraindication Magnetic Resonance Imaging Metallic device / implant Electronic pacemaker
Item
contraindications for subjects undergoing an mr scan (including but not limited to metal implants pacemakers, etc.)
boolean
C1301624 (UMLS CUI [1,1])
C0024485 (UMLS CUI [1,2])
C3693688 (UMLS CUI [1,3])
C0178611 (UMLS CUI [1,4])