dsm-iv
Item
all patients will meet dsm-iv criteria for major depressive episode (without psychotic features).
boolean
C0011581 (UMLS CUI [1,1])
C0220952 (UMLS CUI [1,2])
hamilton rating scale
Item
all patients will have a total score of 18 or higher and a score of at least 3 on item number 1 of the 24 item hamilton rating scale for depression (ham-d).
boolean
C0451203 (UMLS CUI [1])
antidepressant treatment failure
Item
all patients will have failed to respond to at least two separate trials of treatment for at least 4 weeks with therapeutic dosages of antidepressant medication (including at least one ssri) or will have been intolerant of at least three different antidepressant medications (including at least one ssri).
boolean
C0003289 (UMLS CUI [1,1])
C0679864 (UMLS CUI [1,2])
seizure threshold lowering medication
Item
patient medications will be reviewed prior to enrollment in this study. patients taking medications that may lower seizure threshold (e.g. metronidazole) will be excluded if the particular medication cannot be stopped or altered without affecting the patient's routine medical care.
boolean
C0234976 (UMLS CUI [1,1])
C0013227 (UMLS CUI [1,2])
neurological illness; epilepsy; seizure disorder;
Item
history of neurological illness, epilepsy or seizure disorder, intracranial tumor, or major head trauma leading to loss of consciousness of any length.
boolean
C0517960 (UMLS CUI [1,1])
C0027765 (UMLS CUI [1,2])
C0517960 (UMLS CUI [2,1])
C0014544 (UMLS CUI [2,2])
C0517960 (UMLS CUI [3,1])
C0036572 (UMLS CUI [3,2])
C0517960 (UMLS CUI [4,1])
C1527390 (UMLS CUI [4,2])
C0517960 (UMLS CUI [5,1])
C0018674 (UMLS CUI [5,2])
cns disease
Item
evidence of central nervous system disease based on baseline complete neurological examination, eeg and contrast-enhanced computerized tomography or magnetic resonance imaging of the brain.
boolean
C0007682 (UMLS CUI [1])
pacemaker; medication pump; metal implants in head
Item
history of implanted pacemaker or medication pump, metal plate in skull, or metal objects in the eye or skull.
boolean
C0030163 (UMLS CUI [1])
C2076930 (UMLS CUI [2])
C0336580 (UMLS CUI [3,1])
C0018670 (UMLS CUI [3,2])
personality disorder
Item
axis ii diagnosis of cluster a (paranoid, schizoid, or schizotypal) or cluster b (antisocial, borderline, histrionic, or narcissistic) personality disorder.
boolean
C0031212 (UMLS CUI [1])
mental retardation axis 2
Item
axis ii diagnosis of mental retardation.
boolean
C0025362 (UMLS CUI [1,1])
C0945856 (UMLS CUI [1,2])
schizophrenia, schizoaffective disorder, other functional psychosis, rapid-cycling bipolar illness, or alcohol or drug abuse
Item
history of schizophrenia, schizoaffective disorder, other functional psychosis, rapid-cycling bipolar illness, or alcohol or drug abuse within the past year.
boolean
C0036341 (UMLS CUI [1])
C0036337 (UMLS CUI [2])
C0033975 (UMLS CUI [3])
C0005586 (UMLS CUI [4])
C0085762 (UMLS CUI [5])
C0013146 (UMLS CUI [6])
rapid clinical response necessary
Item
need for rapid clinical response due to conditions such as inanition, psychosis, or suicidality (defined as suicide attempt during the current major depressive episode or having a specific plan for committing suicide).
boolean
C4055223 (UMLS CUI [1,1])
C0456962 (UMLS CUI [1,2])
uncontrolled medical condition
Item
a medical condition that is not well controlled, such as diabetes or hypertension, or concomitant medical or nutritional problems necessitating hospitalization.
boolean
C0012634 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
anticonvulsants
Item
patients taking anticonvulsant mood stabilizers (e.g. carbamazepine, valproic acid).
boolean
C0003286 (UMLS CUI [1])
informed consent
Item
patients otherwise unable to grant informed consent.
boolean
C0021430 (UMLS CUI [1])