Nonsquamous nonsmall cell neoplasm of lung Advanced phase | Age | Adult | Malignant Mixed Tumor Histology Procedure
Item
adult patients aged >=18 years with histologically or cytologically confirmed advanced nonsquamous non-small cell lung cancer (nsnsclc). mixed tumors should be categorized according to the predominant histology.
boolean
C2585890 (UMLS CUI [1,1])
C0205179 (UMLS CUI [1,2])
C0001779 (UMLS CUI [2])
C0001675 (UMLS CUI [3])
C0206625 (UMLS CUI [4,1])
C0344441 (UMLS CUI [4,2])
Non-Small Cell Lung Carcinoma | Recurrent disease | Neoplasm Metastasis Stage level 4 | Indication Therapeutic procedure Paclitaxel Carboplatin Avastin
Item
note: nsclc should be predominantly nonsquamous. recurrent or metastatic disease (stage iv) with an indication for therapy with paclitaxel + carboplatin + avastin®.
boolean
C0007131 (UMLS CUI [1])
C0277556 (UMLS CUI [2])
C0027627 (UMLS CUI [3,1])
C0441772 (UMLS CUI [3,2])
C3146298 (UMLS CUI [4,1])
C0087111 (UMLS CUI [4,2])
C0144576 (UMLS CUI [4,3])
C0079083 (UMLS CUI [4,4])
C1135130 (UMLS CUI [4,5])
Malignant Neoplasms | epidermal growth factor receptor activity | anaplastic lymphoma kinase Mutation | Chemotherapy Regimen | Measurable Disease Response Evaluation Criteria in Solid Tumors
Item
patients harboring tumors with unknown or without activating epidermal growth factor receptor (egfr) / anaplastic lymphoma receptor tyrosine kinase (alk) mutation maybe included provided chemotherapy is standard of care. at least one measurable lesion according to response evaluation criteria in solid tumors (recist) 1.1 based on independent central review.
boolean
C0006826 (UMLS CUI [1])
C1150617 (UMLS CUI [2])
C0252409 (UMLS CUI [3,1])
C0026882 (UMLS CUI [3,2])
C0392920 (UMLS CUI [4])
C1513041 (UMLS CUI [5,1])
C1709926 (UMLS CUI [5,2])
ECOG performance status
Item
eastern cooperative oncology group (ecog) performance status (ps) 0 or 1.
boolean
C1520224 (UMLS CUI [1])
Normal liver function | Normal renal function | Bone Marrow Function Adequate
Item
adequate hepatic, renal, and bone marrow function:
boolean
C1848676 (UMLS CUI [1])
C0232805 (UMLS CUI [2])
C0005953 (UMLS CUI [3,1])
C0542341 (UMLS CUI [3,2])
C0205411 (UMLS CUI [3,3])
Life Expectancy Medical Diagnostic Clinical Judgment
Item
life expectancy > 6 months based on clinical judgment. further inclusion criteria apply.
boolean
C0023671 (UMLS CUI [1,1])
C0237512 (UMLS CUI [1,2])
Prior Therapy | Monoclonal Antibodies | Small Molecule inhibitors | Vascular Endothelial Growth Factor A | Vascular Endothelial Growth Factor Receptor | Avastin
Item
prior therapy with monoclonal antibodies or small molecule inhibitors against vascular endothelial growth factor (vegf) or vegf receptors, including avastin®.
boolean
C1514463 (UMLS CUI [1])
C0003250 (UMLS CUI [2])
C1328819 (UMLS CUI [3,1])
C0243077 (UMLS CUI [3,2])
C0078058 (UMLS CUI [4])
C0148199 (UMLS CUI [5])
C1135130 (UMLS CUI [6])
systemic therapy Neoplasm Metastasis | cancer treatment Systemic | Therapeutic radiology procedure | Nonsquamous nonsmall cell neoplasm of lung Advanced phase Locally
Item
prior systemic therapy for metastatic disease. prior systemic anticancer therapy or radiotherapy for locally advanced nsnsclc if completed <12 months prior to screening.
boolean
C1515119 (UMLS CUI [1,1])
C0027627 (UMLS CUI [1,2])
C0920425 (UMLS CUI [2,1])
C0205373 (UMLS CUI [2,2])
C1522449 (UMLS CUI [3])
C2585890 (UMLS CUI [4,1])
C0205179 (UMLS CUI [4,2])
C1517927 (UMLS CUI [4,3])
Malignant Neoplasms Previous | Non-Small Cell Lung Carcinoma | Basal cell carcinoma | Carcinoma in situ of uterine cervix
Item
previous malignancy other than nsclc in the last 5 years except for basal cell cancer of the skin or pre-invasive cancer of the cervix.
boolean
C0006826 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
C0007131 (UMLS CUI [2])
C0007117 (UMLS CUI [3])
C0851140 (UMLS CUI [4])
Metastatic malignant neoplasm to brain Symptomatic | Small cell carcinoma of lung | Squamous cell carcinoma of lung | Non-Small Cell Lung Carcinoma Unspecified | Non-Small Cell Lung Carcinoma Not Otherwise Specified
Item
symptomatic brain metastasis. diagnosis of small cell carcinoma of the lung, squamous cell carcinoma of the lung, nsclc not specified (ns) or nsclc not otherwise specified(nos).
boolean
C0220650 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
C0149925 (UMLS CUI [2])
C0149782 (UMLS CUI [3])
C0007131 (UMLS CUI [4,1])
C0205370 (UMLS CUI [4,2])
C0007131 (UMLS CUI [5,1])
C1518425 (UMLS CUI [5,2])
Toxic effect Unresolved | Common Terminology Criteria for Adverse Events | Alopecia | cancer treatment Previous | Therapeutic radiology procedure
Item
any unresolved toxicity > common toxicity criteria grade 1 (except alopecia) from previous anticancer therapy (including radiotherapy).
boolean
C0600688 (UMLS CUI [1,1])
C0443342 (UMLS CUI [1,2])
C1516728 (UMLS CUI [2])
C0002170 (UMLS CUI [3])
C0920425 (UMLS CUI [4,1])
C0205156 (UMLS CUI [4,2])
C1522449 (UMLS CUI [5])
Congenital bleeding diathesis | hereditary coagulopathy | Bleeding Risk | Thrombosis | Hemorrhagic Disorders
Item
history or evidence of inherited bleeding diathesis or coagulopathy with the risk of bleeding. thrombotic or hemorrhagic event =< 6 months prior to screening. further exclusion criteria apply.
boolean
C1856452 (UMLS CUI [1])
C0679428 (UMLS CUI [2])
C3251812 (UMLS CUI [3])
C0040053 (UMLS CUI [4])
C0019087 (UMLS CUI [5])