diplotype
Item
diplotype: whites with specific diplotype and african americans with specific diplotypes.
boolean
pregnancy lactation pregnancy test
Item
gender: male or female. women are eligible if they are not pregnant or lactating. females subjects of childbearing potential will undergo a urine pregnancy test prior to each methacholine challenge test.
boolean
C0032961 (UMLS CUI [1])
C3831118 (UMLS CUI [2])
C0006147 (UMLS CUI [3])
C0430056 (UMLS CUI [4])
C0430567 (UMLS CUI [5])
age
Item
age: 12 years and older.
boolean
C0001779 (UMLS CUI [1])
asthma
Item
asthma diagnosis: physician diagnosed asthma according to american thoracic society criteria for at least 3 months.
boolean
C0004096 (UMLS CUI [1,1])
C0040223 (UMLS CUI [1,2])
asthma therapy
Item
asthma therapy: there is no requirement for previous asthma therapy to be included in this study.
boolean
C0087111 (UMLS CUI [1,1])
C0004096 (UMLS CUI [1,2])
fev1
Item
asthma severity: forced expiratory volume in the first sectond (fev1) must be >= 60% of predicted normal values for age, height, and gender.
boolean
C0748133 (UMLS CUI [1])
methacholine challenge
Item
methacholine challenge test provocative concentration (20% fall in fev1) of [<=12]mg/ml.
boolean
C0430567 (UMLS CUI [1])
C0748133 (UMLS CUI [2])
life-threatening asthma
Item
history of life-threatening asthma: any episode of asthma requiring intubation associated with hypercapnia, respiratory arrest, or hypoxic seizures.
boolean
C0004096 (UMLS CUI [1,1])
C2826244 (UMLS CUI [1,2])
C0020440 (UMLS CUI [2])
C0021925 (UMLS CUI [3])
C0162297 (UMLS CUI [4])
C1843573 (UMLS CUI [5])
hospitalization for asthma
Item
asthma instability: hospitalization for asthma within 3 months of visit 1.
boolean
C0019993 (UMLS CUI [1,1])
C0004096 (UMLS CUI [1,2])
C0040223 (UMLS CUI [1,3])
respiratory disease
Item
concurrent respiratory disease: any respiratory disease other than asthma.
boolean
C0035204 (UMLS CUI [1])
sensitivities
Item
sensitivities: sensitivities to methacholine, flovent® mdi, ipratropium bromide, albuterol, or advair diskus® that would put the safety of the subject at risk.
boolean
C0020517 (UMLS CUI [1,1])
C0600370 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0720466 (UMLS CUI [2,2])
C0020517 (UMLS CUI [3,1])
C0700580 (UMLS CUI [3,2])
C0020517 (UMLS CUI [4,1])
C0001927 (UMLS CUI [4,2])
C0020517 (UMLS CUI [5,1])
C0939246 (UMLS CUI [5,2])
respiratory tract infection
Item
respiratory tract infection: any sinus, middle ear, oropharyngeal, upper or lower respiratory tract infection that has not resolved at least 2 weeks immediately preceding visit 1, or for which antibiotic therapy has not been completed at least 2 weeks prior to visit 1.
boolean
C0035243 (UMLS CUI [1,1])
C0040223 (UMLS CUI [1,2])
C0003232 (UMLS CUI [2])
exposure to pollen allergen
Item
expected exposure to pollen allergen to which the patient is sensitive (by medical history of symptoms) during the 29 day study period. these patients can be studied when pollen exposure to which they are sensitive will not occur.
boolean
C0332157 (UMLS CUI [1,1])
C0323138 (UMLS CUI [1,2])
C0020517 (UMLS CUI [1,3])