Healthy | Body Weight | Body mass index
Item
part 1 (healthy participants): participant must have a body weight in the range of 50 to 100 kilogram (kg) inclusive and have a body mass index (bmi) of 19 to 30 kilogram per meter square (kg/m^2) inclusive
boolean
C3898900 (UMLS CUI [1])
C0005910 (UMLS CUI [2])
C1305855 (UMLS CUI [3])
Healthy | Physical Examination | Medical History | Vital signs | 12 lead ECG
Item
part 1 (healthy participants): participant must be healthy on the basis of physical examination, medical history, vital signs and 12-lead ecg performed at screening
boolean
C3898900 (UMLS CUI [1])
C0031809 (UMLS CUI [2])
C0262926 (UMLS CUI [3])
C0518766 (UMLS CUI [4])
C0430456 (UMLS CUI [5])
Asthma | Body Weight | Body mass index
Item
part 2 (asthma participants): participant must have a body weight in the range of 50 to 125 kg inclusive and have a bmi of 19 to 32 kg/m^2 inclusive
boolean
C0004096 (UMLS CUI [1])
C0005910 (UMLS CUI [2])
C1305855 (UMLS CUI [3])
Asthma
Item
part 2 (asthma participants): participant must have a physician documented diagnosis of asthma for at least 12 months before screening
boolean
C0004096 (UMLS CUI [1])
Dermatitis, Atopic | Body Weight | Body mass index
Item
part 2 (atopic dermatitis participants): participant must have a body weight in the range of 50 to 100 kg inclusive and have a bmi of 19 to 30 kg/m^2 inclusive
boolean
C0011615 (UMLS CUI [1])
C0005910 (UMLS CUI [2])
C1305855 (UMLS CUI [3])
Dermatitis, Atopic
Item
part 2 (atopic dermatitis participants): participant has physician documented diagnosis of atopic dermatitis for at least 12 months before screening based on uk refinements of the rajka and hanifin criteria
boolean
C0011615 (UMLS CUI [1])
Healthy | Malignant Neoplasms | Basal cell carcinoma | Intraepithelial Squamous Cell Carcinoma
Item
part 1 (healthy participants): participant has any known malignancy or history of malignancy, with the exception of basal cell carcinoma or squamous cell carcinoma in situ of the skin that has been treated with no evidence of recurrence within 6 months prior to the screening visit
boolean
C3898900 (UMLS CUI [1])
C0006826 (UMLS CUI [2])
C0007117 (UMLS CUI [3])
C0334245 (UMLS CUI [4])
Healthy | Cardiovascular Diseases | Angina Pectoris | Myocardial Infarction | Congestive heart failure | Atherosclerosis | Cardiac Arrhythmia
Item
part 1 (healthy participants): participant currently has or has a history of any clinically significant cardiovascular disease, including but not limited to a history of angina or myocardial infarction, congestive heart failure, symptomatic atherosclerotic vascular disease, or arrhythmia.
boolean
C3898900 (UMLS CUI [1])
C0007222 (UMLS CUI [2])
C0002962 (UMLS CUI [3])
C0027051 (UMLS CUI [4])
C0018802 (UMLS CUI [5])
C0004153 (UMLS CUI [6])
C0003811 (UMLS CUI [7])
Asthma | Malignant Neoplasms | Basal cell carcinoma | Intraepithelial Squamous Cell Carcinoma
Item
part 2 (asthma participants): participant has any known malignancy or history of malignancy, with the exception of basal cell carcinoma or squamous cell carcinoma in situ of the skin that has been treated with no evidence of recurrence within 6 months prior to the screening visit
boolean
C0004096 (UMLS CUI [1])
C0006826 (UMLS CUI [2])
C0007117 (UMLS CUI [3])
C0334245 (UMLS CUI [4])
Asthma | Communicable Diseases | Sepsis | Pneumonia | Pyelonephritis | Hospitalization | Intravenous Antibiotics
Item
part 2 (asthma participants): participant has or have had a serious infection (eg, sepsis, pneumonia or pyelonephritis), or have been hospitalized or received iv antibiotics for a serious infection during the 4 months prior to the screening visit
boolean
C0004096 (UMLS CUI [1])
C0009450 (UMLS CUI [2])
C0243026 (UMLS CUI [3])
C0032285 (UMLS CUI [4])
C0034186 (UMLS CUI [5])
C0019993 (UMLS CUI [6])
C0348016 (UMLS CUI [7,1])
C0003232 (UMLS CUI [7,2])
Dermatitis, Atopic | Malignant Neoplasms | Basal cell carcinoma | Intraepithelial Squamous Cell Carcinoma
Item
part 2 (atopic dermatitis participants): participant has any known malignancy or history of malignancy, with the exception of basal cell carcinoma or squamous cell carcinoma in situ of the skin that has been treated with no evidence of recurrence within 6 months prior to the screening visit.
boolean
C0011615 (UMLS CUI [1])
C0006826 (UMLS CUI [2])
C0007117 (UMLS CUI [3])
C0334245 (UMLS CUI [4])
Dermatitis, Atopic | Communicable Diseases | Sepsis | Pneumonia | Pyelonephritis | Hospitalization | Intravenous Antibiotics
Item
part 2 (atopic dermatitis participants): participant has or have had a serious infection (eg, sepsis, pneumonia or pyelonephritis), or have been hospitalized or received iv antibiotics for a serious infection during the 4 months prior to the screening visit
boolean
C0011615 (UMLS CUI [1])
C0009450 (UMLS CUI [2])
C0243026 (UMLS CUI [3])
C0032285 (UMLS CUI [4])
C0034186 (UMLS CUI [5])
C0019993 (UMLS CUI [6])
C0348016 (UMLS CUI [7,1])
C0003232 (UMLS CUI [7,2])