clinical diagnosis of apl morphology or fab m3 variant confirmed by rt-pcr assay or chromosome analysis/fish showing t(15:17) translocation. patients must also have relapse from, resistance to or intolerance of any one or more of the following therapies:

ATRA - Tretinoin

Cytotoxic chemotherapy

arsenic trioxide

patients must be 18 or older

bilirubin equal or less than 1.5 times the upper limit of normal.

creatinine equal or less than 1.5 times the upper limit of normal.

patients entered into this study should be non-pregnant and non-nursing and should not plan on becoming pregnant while on treatment. treatment under this protocol would expose an unborn child to significant risks. women and men of reproductive potential should agree to use an effective means of birth control. there is an extremely high risk that a severely deformed infant will result if nrx 195183 is administered during pregnancy.

non-apl, aml patients should be excluded from the study.

other serious illnesses which would limit survival to 6 months.

psychiatric conditions which would prevent compliance with treatment or informed consent.

uncontrolled or severe cardiovascular disease. this would include history of a recent acute myocardial infarction, uncontrolled congestive heart failure, or active angina.

aids or hiv positive patients, although hiv test is not required for accrual.