Juvenile Myelomonocytic Leukemia
Item
patients must have a diagnosis of jmml and fulfill these minimal criteria (international diagnostic criteria for jmml):
boolean
C0349639 (UMLS CUI [1])
White blood count and absolut monocyte count
Item
leukocytosis (> 13,000) with absolute monocytosis (> 1,000)
boolean
C0023508 (UMLS CUI [1])
C0200637 (UMLS CUI [2])
immature myeloid cells
Item
the presence of immature myeloid cells in the peripheral blood
boolean
C3826992 (UMLS CUI [1])
Bone marrow blasts
Item
less than 30% marrow blasts
boolean
C1982687 (UMLS CUI [1])
t(9:22) or bcr-abl
Item
absence of t(9:22) or bcr-abl transcript
boolean
C3897138 (UMLS CUI [1])
C1835417 (UMLS CUI [2])
Organ function
Item
adequate major organ function including:
boolean
C0678852 (UMLS CUI [1])
Ejection fraction
Item
cardiac: ejection fraction > 45%
boolean
C0232174 (UMLS CUI [1])
Liver function
Item
hepatic: no clinical evidence of hepatic failure (e.g. coagulopathy, ascites)
boolean
C0232741 (UMLS CUI [1])
Karnofsky performance status or Lansky score
Item
karnofsky performance status > 70% or lansky score > 50%
boolean
C0206065 (UMLS CUI [1])
C1522275 (UMLS CUI [2])
Creatinine
Item
creatinine must be < 2 x normal for age
boolean
C0201976 (UMLS CUI [1])
Informed consent
Item
written informed consent.
boolean
C0021430 (UMLS CUI [1])
Infection
Item
active uncontrolled infection within one week of hct.
boolean
C0009450 (UMLS CUI [1])