Age | Non-smoker
Item
aged: 18-80 years 61-80 years to be non-smokers only
boolean
C0001779 (UMLS CUI [1])
C0337672 (UMLS CUI [2])
Asthma
Item
evidence of asthma: a diagnostic code for asthma or two scripts for asthma..
boolean
C0004096 (UMLS CUI [1])
fluticasone | salmeterol | Therapeutic procedure | inhaled steroids | Adrenergic beta-2 Receptor Agonists | Therapeutic procedure
Item
baseline fp/sal therapy: ≥2 prescription for ics/laba therapy as fp/sal
boolean
C0082607 (UMLS CUI [1,1])
C0073992 (UMLS CUI [1,2])
C0087111 (UMLS CUI [1,3])
C2065041 (UMLS CUI [2,1])
C2936789 (UMLS CUI [2,2])
C0087111 (UMLS CUI [2,3])
Continuous therapeutic procedure | prescription
Item
evidence of continuing therapy: include only patients who receive ≥2 prescriptions for the therapy under study during the outcome year (i.e. ≥1 prescription at the index date and ≥1 other). uk average is 3-4 prescriptions refilled per year, so ≥2 ensures capture of "real-life" data.
boolean
C0087111 (UMLS CUI [1,1])
C0549178 (UMLS CUI [1,2])
C1521941 (UMLS CUI [2])
Therapy change | fluticasone salmeterol
Item
evidence of switching for economic reasons: fp/sal patients from practices with ≥5 switches to fostair in a 3 month period to minimise data taken from switching of anomalous patients; optimal practices for inclusion are those switching "wholesale" for economic reasons.
boolean
C3665894 (UMLS CUI [1])
C0082607 (UMLS CUI [2,1])
C0073992 (UMLS CUI [2,2])
C0087111 (UMLS CUI [2,3])
Chronic disease of respiratory system
Item
any chronic respiratory disease other than asthma
boolean
C0264220 (UMLS CUI [1])
C0004096 (UMLS CUI [2])
Oral steroid therapy
Item
are receiving maintenance oral steroid therapy during baseline period
boolean
C0001617 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])