Non-hodgkins lymphoma of the cns
Item
histologically or cytologically/immunocytologically confirmed primary non-hodgkin's lymphoma of the cns. a central reference pathological report will be made on inclusion into the study (prof. dr. pietsch, reference center for brain tumors of the german society for neuropathology and neuroanatomy, institute of neuropathology of the bonn university hospital). histological diagnosis is usually performed by preferential stereotactic biopsy of suspicious lesions in the brain or spinal cord. the diagnosis from cerebrospinal fluid (csf) requires the detection of malignant lymphocytes according to cytological and immunocytological criteria. there should be no more than 2 weeks between establishing the diagnosis and inclusion in the study. the availability of the reference pathological report is not absolutely necessary for inclusion in the study and beginning therapy.
boolean
C0024305 (UMLS CUI [1,1])
C0280803 (UMLS CUI [1,2])
Age
Item
aged > 18 years
boolean
C0001779 (UMLS CUI [1])
Life expectancy
Item
life expectancy of at least 2 months
boolean
C0023671 (UMLS CUI [1])
Bone marrow function, liver function and renal function
Item
adequate bone marrow reserve with a peripheral granulocyte count of > 1,500/µl and thrombocyte count of > 100,000/µl; bilirubin in the normal range; got of < three times the upper normal limit and adequate renal function with a creatinine clearance of > 50 ml/min and serum creatinine in the normal range.
boolean
C0857490 (UMLS CUI [1])
C0005821 (UMLS CUI [2])
C1278039 (UMLS CUI [3])
C0201899 (UMLS CUI [4])
C0373595 (UMLS CUI [5])
C0201976 (UMLS CUI [6])
Written informed consent
Item
written informed consent
boolean
C0021430 (UMLS CUI [1])
Gynaecological status
Item
in women of child-bearing age, pregnancy is excluded, effective contraception is necessary, and women should not be breast feeding.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0700589 (UMLS CUI [3])
Site affected by lymphoma
Item
manifestation of lymphoma outside of the cns
boolean
C0024299 (UMLS CUI [1,1])
C0449642 (UMLS CUI [1,2])
Comorbidity and Karnofsky Performance Status
Item
severe diseases in other organs which would make performing intensive chemotherapy impossible; karnofsky index > 50% due to previous diseases other than pcnsl. karnofsky > 30 will be accepted only due to the pcnsl.
boolean
C0009488 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0392920 (UMLS CUI [1,3])
C0206065 (UMLS CUI [2])
Active infection
Item
active infection
boolean
C0009450 (UMLS CUI [1])
HIV positivity
Item
HIV positivity
boolean
C0019699 (UMLS CUI [1])
Pcnsl Treatment
Item
previous treatment of pcnsl other than with corticosteroids, antiepileptics or diuretics
boolean
C0280803 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])
Radiotherapy to brain
Item
previous radiotherapy of the brain
boolean
C0948319 (UMLS CUI [1])
Cancer
Item
concomitant or previous malignant diseases in the last 5 years except for an adequately treated basal cell carcinoma or cervical carcinoma in situ
boolean
C0006826 (UMLS CUI [1,1])
C0332196 (UMLS CUI [1,2])
C0007117 (UMLS CUI [1,3])
C0006826 (UMLS CUI [2,1])
C0332196 (UMLS CUI [2,2])
C2216722 (UMLS CUI [2,3])
Immunosuppression and organ transplantation
Item
immunosuppression, concomitant immunosuppressive therapy, or organ transplantation
boolean
C0029216 (UMLS CUI [1])
C0021079 (UMLS CUI [2])
Chemotherapy
Item
ongoing chemotherapy for another disease
boolean
C0392920 (UMLS CUI [1])