ID.1
Item
diagnosis of one of the following
boolean
de novo aml
Item
newly diagnosed de novo acute myeloid leukemia (aml)
boolean
C0023467 (UMLS CUI [1,1])
C1515568 (UMLS CUI [1,2])
secondary AML
Item
aml secondary to myelodysplastic syndromes (mds)
boolean
C0280449 (UMLS CUI [1])
C3463824 (UMLS CUI [2])
secondary aml to leukemogenic therapy
Item
aml secondary to exposure to leukemogenic therapy or agents with primary malignancy in remission for at least 2 years
boolean
C0280449 (UMLS CUI [1])
C0087111 (UMLS CUI [2,1])
C2983796 (UMLS CUI [2,2])
bone marrow blasts
Item
bone marrow blasts >30%
boolean
C1982687 (UMLS CUI [1])
age
Item
age ≥ 65 years
boolean
C0001779 (UMLS CUI [1])
ECOG
Item
easter cooperative oncology group (ecog) 0-2
boolean
C1520224 (UMLS CUI [1])
prior therapy for aml
Item
previous cytotoxic or biologic treatment for aml (except hydroxyurea)
boolean
C0023467 (UMLS CUI [1,1])
C1514463 (UMLS CUI [1,2])
C0020402 (UMLS CUI [2])
previous treatment with azacitidine, decitabine or cytarabine
Item
previous treatment with azacitidine, decitabine or cytarabine
boolean
C0004475 (UMLS CUI [1,1])
C1514463 (UMLS CUI [1,2])
C0049065 (UMLS CUI [2,1])
C1514463 (UMLS CUI [2,2])
C0010711 (UMLS CUI [3,1])
C1514463 (UMLS CUI [3,2])
prior use of targeted therapy agents
Item
prior use of targeted therapy agents (e.g., flt3 inhibitors, other kinase inhibitors)
boolean
C2985566 (UMLS CUI [1,1])
C1514463 (UMLS CUI [1,2])
AML m3
Item
aml french american british subtype (fab m3)
boolean
C0023487 (UMLS CUI [1])
aml cytogenetics
Item
aml associated with inv(16), t(8;21), t(16;16), t(15:17), or t(9;22) karyotypes
boolean
C0023467 (UMLS CUI [1,1])
C0008625 (UMLS CUI [1,2])
prior bone marrow or stem cell transplantation
Item
prior bone marrow or stem cell transplantation
boolean
C0005961 (UMLS CUI [1,1])
C0332152 (UMLS CUI [1,2])
C1504389 (UMLS CUI [2,1])
C0332152 (UMLS CUI [2,2])
candidate for allogeneic bone marrow or stem cell transplant
Item
candidate for allogeneic bone marrow or stem cell transplant
boolean
C0005961 (UMLS CUI [1])
C1504389 (UMLS CUI [2])
malignant disease
Item
diagnosis of malignant disease within the previous 12 months (excluding base cell carcinoma, "in-situ" carcinoma of the cervix or breast or other local malignancy excised or irradiated with a high probability of cure)
boolean
C0006826 (UMLS CUI [1])
malignant neoplasm of the liver
Item
malignant hepatic tumors
boolean
C0345904 (UMLS CUI [1])
uncontrolled systemic infection
Item
uncontrolled systemic infection
boolean
C3646020 (UMLS CUI [1])
hiv, hepatitis b or c
Item
active viral infection with human immunodeficiency virus (hiv) or hepatitis type b or c
boolean
C0019682 (UMLS CUI [1])
C0019163 (UMLS CUI [2])
C0019196 (UMLS CUI [3])
experimental drug use
Item
use of any experimental drug or therapy within 28 days prior to day 1
boolean
C0304229 (UMLS CUI [1])