infection Hepatitis C; Genotype
Item
have a diagnosis of hcv infection, genotype 1 or genotype 3
boolean
C3714514 (UMLS CUI [1,1])
C0019196 (UMLS CUI [1,2])
combination therapy ribavirin
Item
be eligible for standard combination therapy with pegylated ifn and ribavirin
boolean
C0013218 (UMLS CUI [1,1])
C0035525 (UMLS CUI [1,2])
age
Item
be at least 18 but no more than 65 years of age
boolean
C0001779 (UMLS CUI [1])
informed consent
Item
have signed an informed consent indicating that the patient is aware of the infectious nature of their disease and have been informed of the procedures of the protocol, the experimental nature of the therapy, alternatives, potential benefits, side effects, risks, and discomforts
boolean
C0021430 (UMLS CUI [1])
compliance
Item
be willing and able to comply with scheduled visits, the treatment plan, and laboratory tests
boolean
C1321605 (UMLS CUI [1])
contraindication rimantadine
Item
have no contraindications to receiving rimantadine therapy
boolean
C1301624 (UMLS CUI [1,1])
C0035629 (UMLS CUI [1,2])
haemoglobin; platelet count
Item
have blood results within defined acceptable haematological and biochemical parameters (haemoglobin >10 g/dl, platelet count >150 x 109/l, bilirubin <25 umol/l, albumin >35 g/l, creatinine <150 umol/l
boolean
C0518015 (UMLS CUI [1])
C0032181 (UMLS CUI [2])
Informed Consent Limited Comorbidity
Item
have dementia or altered mental status that would prohibit informed consent
boolean
C0021430 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
C0009488 (UMLS CUI [1,3])
therapy hepatitis c
Item
have previously received treatment for hcv infection (i.e. are currently treatment naïve)
boolean
C0087111 (UMLS CUI [1,1])
C0019196 (UMLS CUI [1,2])
comorbidity affecting treatment
Item
have any condition which would deem the patient ineligible for combination therapy with pegylated ifn or ribavirin. this includes pregnancy, significant cardiac, renal or autoimmune disease, severe depression or psychosis, and previous organ transplantation
boolean
C0009488 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0087111 (UMLS CUI [1,3])
cirrhosis; liver failure; encephalopathy
Item
cirrhosis or liver failure as evidenced by clinical (cutaneous stigmata of chronic liver disease, ascites, encephalopathy), ultrasonic (cirrhotic appearance of liver, ascites) or biochemical (platelet count >150 x 109/l, bilirubin <25 umol/l, albumin >35 g/l) evidence, routinely collated in all patients diagnosed with hcv
boolean
C0023890 (UMLS CUI [1])
C0085605 (UMLS CUI [2])
C0085584 (UMLS CUI [3])
rimantadine; epilepsy; Renal Insufficiency
Item
any condition which would preclude the use of rimantadine. this comprises significant renal impairment (creatinine >150), pregnancy, epilepsy or history of unexplained seizures
boolean
C0035629 (UMLS CUI [1])
C0014544 (UMLS CUI [2])
C1565489 (UMLS CUI [3])
Compliance behavior Limited Comorbidity
Item
have any other severe, acute, or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or study drug administration or may interfere with the interpretation of study results and, in the judgment of the chief investigators, would make the patient inappropriate for this study. this includes the presence of end stage liver disease (cirrhosis), and hiv infection
boolean
C1321605 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
C0009488 (UMLS CUI [1,3])