Gender, Age
Item
male or female between the ages of 18 and 60. (the upper age is limited to 60 because thyroid changes, including blunting of the tsh response to trh occurs with age and can potentially confound the relationship between the hpt axis and mdd.)
boolean
C0079399 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
major depressive disorder
Item
primary diagnosis of unipolar major depressive disorder
boolean
C1269683 (UMLS CUI [1])
ham-d 21
Item
ham-d (21 item) score >18
boolean
C3640518 (UMLS CUI [1])
alcohol abuse or alcohol dependence
Item
alcohol abuse or alcohol dependence within the past year.
boolean
C0038586 (UMLS CUI [1])
psychoactive substance abuse or dependence
Item
psychoactive substance abuse or dependence within the past year.
boolean
C0038586 (UMLS CUI [1])
severe personality disorder limiting compliance
Item
clinical evidence of severe personality disorder that would make study participation and completion unlikely.
boolean
C1321605 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
C0009488 (UMLS CUI [1,3])
ECT
Item
ect within the past 6 months.
boolean
C0013806 (UMLS CUI [1])
hypothyroidism, hyperthyroidism
Item
grade i hypothyroidism defined as low thyroid hormone levels with an associated elevated tsh; hyperthyroidism defined as elevated thyroid hormone concentrations with a low tsh.
boolean
C0020676 (UMLS CUI [1])
C0020550 (UMLS CUI [2])
serious and unstable medical illnesses
Item
serious and unstable medical illnesses.
boolean
C0009488 (UMLS CUI [1])