dsm-iv criteria
Item
the patient will satisfy the dsm-iv criteria for dementia of the alzheimer’s type.
boolean
C0220952 (UMLS CUI [1,1])
C1387192 (UMLS CUI [1,2])
nincds/adrda criteria
Item
the patient will satisfy the nincds/adrda criteria for the clinical diagnosis of probable alzheimer’s disease (appendix i).
boolean
C2828081 (UMLS CUI [1])
severity of dementia
Item
the severity of dementia for each patient will be quantified by a mini-mental state examination (mmse) score between 10 and 26 (both inclusive).
boolean
C0451306 (UMLS CUI [1])
residence
Item
the patient is living at home or in a home for the elderly.
boolean
C0237096 (UMLS CUI [1])
Caregiver
Item
the patient has a responsible caregiver who is able to provide information about the patient’s functional status.
boolean
C0085537 (UMLS CUI [1])
Informed consent
Item
written informed consent is obtained from the patient or the legally accepted representative.
boolean
C0021430 (UMLS CUI [1])
Vascular dementia
Item
the patient satisfies the ninds-airen criteria for probable vascular dementia.
boolean
C0011269 (UMLS CUI [1])
Allergy
Item
a known exaggerated pharmacological sensitivity or allergy to nsaid’s.
boolean
C0020517 (UMLS CUI [1,1])
C0003211 (UMLS CUI [1,2])
Gastrointestinal status
Item
history of peptic ulceration, gastric surgery or gastrointestinal bleeding.
boolean
C0030920 (UMLS CUI [1])
C0192398 (UMLS CUI [2])
C0017181 (UMLS CUI [3])
peptic ulceration
Item
current diagnosis of active peptic ulceration.
boolean
C0030920 (UMLS CUI [1])
cardiovascular status
Item
current diagnosis of severe and unstable cardiovascular disease.
boolean
C0007222 (UMLS CUI [1])
renal function
Item
current diagnosis of renal failure.
boolean
C0035078 (UMLS CUI [1])
Comorbidity
Item
advanced, severe and unstable disease of any type, other than alzheimer’s disease, that may interfere with primary and secondary variable evaluations, including a medical condition which should be expected to progress, recur, or change to such an extent that it may bias the assessment of the clinical or mental status of the patient to a significant degree or put the patient at special risk.
boolean
C2348568 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
C0009488 (UMLS CUI [1,3])
Pharmacotherapy
Item
intake of any of the following concomitant medications: salicylates, coumarin derivatives, ace-inhibitors, loop diuretics.
boolean
C0036075 (UMLS CUI [1])
C0010207 (UMLS CUI [2])
C0003015 (UMLS CUI [3])
C0354100 (UMLS CUI [4])
Pharmacotherapy
Item
intake of any of the following concomitant medications more than two months immediately prior or during the study: nsaid’s, systemic corticosteroids.
boolean
C0003211 (UMLS CUI [1])
C3653708 (UMLS CUI [2])
Pharmacotherapy
Item
intake of any of the following concomitant medications with a possible effect on cognition: estrogen, deprenyl, vitamin e, neuroleptics, anticholinergics. patients using stable doses of cholinesterase inhibitors were eligible, with the provision that the dose should not be changed during the study. cholinesterase inhibitors could not be initiated during the study.
boolean
C3541386 (UMLS CUI [1])
C0086130 (UMLS CUI [2])
C1142098 (UMLS CUI [3])
C0040615 (UMLS CUI [4])
C0242896 (UMLS CUI [5])
C0008429 (UMLS CUI [6,1])
C0008429 (UMLS CUI [6,2])
Alcohol consumption
Item
excessive use of alcohol (more than 5 units per day)
boolean
C0001948 (UMLS CUI [1])
Compliance
Item
the patient is, either alone or with the aid of a caregiver, not able to reliably take the medication.
boolean
C0013216 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
C1321605 (UMLS CUI [1,3])