major depression
Item
all subjects will meet dsm-iv criteria for major depression based upon the structured clinical interview for dsm-iv - patient version (scid-p) (first et al., 1994). all research personnel have undergone scid-p training, and soon will extend this training to the dsm-iv version.
boolean
C1269683 (UMLS CUI [1])
hamd
Item
subjects also will have a score on the 17-item hamilton depression rating scale of > 18 (with item #1 > 2).
boolean
C0451203 (UMLS CUI [1])
clinician care
Item
all subjects will be under the care of a clinician not affiliated with the study at the time of entry into the study, and through the course of the study.
boolean
serious medical illness
Item
subjects will have no serious medical illness.
boolean
C0009488 (UMLS CUI [1])
axis i diagnoses
Item
we will exclude patients also meeting criteria for the following groups of axis i diagnoses: delirium or dementia, substance-related disorders, schizophrenia or other psychotic disorders, or eating disorders.
boolean
C0270287 (UMLS CUI [1])
C0011206 (UMLS CUI [2])
C0497327 (UMLS CUI [3])
C0236969 (UMLS CUI [4])
C0036341 (UMLS CUI [5])
C0033975 (UMLS CUI [6])
C0013473 (UMLS CUI [7])
axis ii diagnoses
Item
in addition, patients meeting criteria for cluster a or b axis ii diagnoses will be excluded.
boolean
C0270288 (UMLS CUI [1])
suicidal, fluoxetin response
Item
subjects with a history of current or past active suicidal ideation, or suicide attempts will be excluded, as will patients who previously have failed to respond to an adequate clinical trial of fluoxetine, or have failed to tolerate the medication.
boolean
C0438696 (UMLS CUI [1])
C0016365 (UMLS CUI [2])
C0521982 (UMLS CUI [3])
suboptimal trials
Item
subjects who have had suboptimal trials, however, may still be considered for the study.
boolean