Multi vessel coronary artery disease
Item
patients aged 40 years with angiographically proven multivessel coronary artery disease defined as at least two major epicardial vessels with any combination of either (a) >50% luminal stenosis, or (b) previous revascularization (percutaneous coronary intervention or coronary artery bypass graft surgery).
boolean
C1299432 (UMLS CUI [1])
Informed Consent
Item
provision of informed consent prior to any study specific procedures
boolean
C0021430 (UMLS CUI [1])
Acute Coronary Syndrome
Item
an acute coronary syndrome within the last 12 months
boolean
C0948089 (UMLS CUI [1])
Anti-platelet drug therapy
Item
an indication for dual anti-platelet therapy, such as drug eluting stent
boolean
C2963157 (UMLS CUI [1])
Inability to take aspirin
Item
inability to take aspirin
boolean
C0004057 (UMLS CUI [1])
Thienopyridine therapy
Item
receiving thienopyridine therapy such as clopidogrel or prasugrel
boolean
C1120149 (UMLS CUI [1])
Percutaneous coronary intervention
Item
percutaneous coronary intervention or coronary artery bypass graft surgery within the last 3 months
boolean
C1532338 (UMLS CUI [1])
C0010055 (UMLS CUI [2])
Informed Consent
Item
inability or unwilling to give informed consent
boolean
C0021430 (UMLS CUI [1])
Child-bearing potential
Item
woman with child-bearing potential and who are breastfeeding will not be enrolled into the trial (woman who have experienced menarche, are pre-menopausal, have not been sterilised or who are currently pregnant)
boolean
C1960468 (UMLS CUI [1])
Hypersensitivity
Item
known hypersensitivity to ticagrelor or one of its excipients
boolean
C0020517 (UMLS CUI [1,1])
C1999375 (UMLS CUI [1,2])
Pathological bleeding
Item
active pathological bleeding or bleeding diathesis
boolean
C0005779 (UMLS CUI [1])
Thrombocytopenia
Item
significant thrombocytopenia: <100 x 10^9 /l
boolean
C0040034 (UMLS CUI [1])
Intracranial Hemorrhages
Item
history of intracranial haemorrhage
boolean
C0151699 (UMLS CUI [1])
Liver impairment
Item
moderate to severe liver impairment (child's grade b or c)
boolean
C0023895 (UMLS CUI [1])
Therapy with strong cytochrome p450 3a4 (cyp3a4) inhibitors
Item
maintenance therapy with strong cytochrome p450 3a4 (cyp3a4) inhibitors, such as ketoconazole, nefazodone, ritonavir, indinavir, atazanavir, or clarithromycin
boolean
C3830624 (UMLS CUI [1])
Intercurrent illness
Item
major intercurrent illness or life expectancy <1 year
boolean
C3640977 (UMLS CUI [1])
C0023671 (UMLS CUI [2])
Renal dysfunction
Item
renal dysfunction (egfr ≤30 ml/min/1.73 m2)
boolean
C3279454 (UMLS CUI [1])
Contrast agents
Item
contraindication to iodinated contrast agents
boolean
C0009924 (UMLS CUI [1])
Coronary revascularisation or major non-cardiac surgery
Item
planned coronary revascularization or major non-cardiac surgery in the next 12 months
boolean
C0877341 (UMLS CUI [1])
C0543467 (UMLS CUI [2])
Simvastatin therapy
Item
maintenance therapy with simvastatin at doses greater than 40mg daily
boolean
C0074554 (UMLS CUI [1])
Receiving oral anticoagulants
Item
receiving oral anticoagulants including warfarin, rivaroxaban, dabigatran or apixaban.
boolean
C0354604 (UMLS CUI [1])