Exclusion Criteria
1. Diagnosis of Secondary Progressive MS, Primary Progressive MS or Progressive Relapsing MS.
boolean
2.Normal baseline brain MRI.
boolean
3. History of any clinically significant autoimmune disease: inflammatory bowel disease, diabetes, lupus or severe asthma.
boolean
4. Current or prior malignancies (excluding non-melanoma skin carcinoma or in situ carcinoma of the cervix that has been adequately treated.)
boolean
5. Significant organ dysfunction, including cardiac, renal (eGFR ≤ 60 ml/min.), liver, central nervous system, pulmonary, vascular, gastrointestinal, endocrine, or metabolic (e.g., creatinine ≥ 1.6 mg/dL; ALT or AST ≥ 1.5x the upper limit of normal), history of myocardial infarction, congestive heart failure, or arrhythmias within 6 months prior to enrollment.the upper limit of normal), history of myocardial infarction, congestive heart failure, or arrhythmias within 6 months prior to enrollment.
boolean
6. Steroid therapy within 60 days prior to enrollment, with the exception of corticosteroids or ACTH for relapse treatment during the course of the study.
boolean
7. Known allergy to Gadolinium-DTPA
boolean
8. Therapy with any immunomodulatory drugs within 3 months prior to enrollment, including but not limited to interferons, glatiramir acetate, BG-12, teriflunomide, laquinimod and IV immunoglobulin.
boolean
9. Treatment at any time with immunosuppressive drugs such as cladribine, total lymphoid irradiation, monoclonal antibody treatment, mitoxantrone, Tysabri, fingolimod, cytoxan, methotrexate.
boolean
10. Participation in any investigational therapy within one year prior to enrollment, unless given approval by PI.
boolean
11. Known or suspected current or past alcohol or drug abuse within one year prior to enrollment.
boolean
12. Any medical, psychiatric or other condition that could result in a subject not being able to comply with protocol requirements.
boolean