ID
4577
Beskrivning
The goal of the study is to examine the cortical activity during speech perception and speech production in idiopathic stutterers compared to fluent speakers. Therefore, the noninvasive method of magnetoencephalography (MEG) is used. A better understanding for the complexity of speech perception and its pathology should be developed. Fundamental properties of stuttering are repetitions, prolongations, and blocks. In most cases stuttering emerges between 2 and 5 years of age. The auditory feedback should become less important during development, as soon as information about mispronounced words does not occur anymore. During speech development this control function should be adopted by other systems. In stutterers the dominance of the acoustic control should remain. Brain imaging studies with positron emission tomography (PET) or magnetic resonance imaging (MRI) show defects in the network of motor system, in the lateralization of speech areas, and functions of the auditory cortex. Magnetoencephalographic studies describe a similar variety as cause of stuttering. There may be defects in the auditory feedback, a modification of the lateralization of speech areas, or an alteration of co-action of motor planning and auditory system. The benefit of magnetoencephalography is a very good temporal resolution in the range of milliseconds combined with good spatial resolution. Therefore, it is well suited to examine the dynamics of cortical processing during stuttering. In this study evoked components of the auditory systems related to complex sounds, vocals, consonant-vocal combinations, and single words are analyzed. Differences of these components in the auditory cortices of stutterers and fluent speakers are hypothesized as well in temporal structure as in localization and lateralization.
Nyckelord
Versioner (1)
- 2013-12-11 2013-12-11 - Martin Dugas
Uppladdad den
11 december 2013
DOI
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Licens
Creative Commons BY-NC 3.0 Legacy
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Eligibility NCT00148161 # Stuttering
Eligibility
- StudyEvent: Eligibility
Beskrivning
Exclusion criteria
Beskrivning
Neurological diseases
Datatyp
boolean
Alias
- UMLS CUI
- C0027765
- ICD10CM
- G00-G99
- ICD9CM
- 349.9
- MDR
- 10029202
- SNOMED CT 2010_0731
- 118940003
Beskrivning
Psychiatric diseases
Datatyp
boolean
Alias
- UMLS CUI
- C0004936
- ICD10CM
- F01-F99
- ICD9CM
- 290-319.99
- MDR
- 10061284
- SNOMED CT 2010_0731
- 74732009
Beskrivning
Medication with neurological effective drugs
Datatyp
boolean
Alias
- UMLS CUI
- C0007680
- SNOMED CT 2010_0731
- 372752008
Beskrivning
Implants with magnetic impact
Datatyp
boolean
Alias
- UMLS CUI
- C0021102
- SNOMED CT 2010_0731
- #####
Beskrivning
Medical Concepts
Beskrivning
Age
Datatyp
string
Alias
- UMLS CUI
- C0001779
- SNOMED CT 2010_0731
- 424144002
- LNC
- MTHU010047
Beskrivning
Gender
Datatyp
string
Alias
- UMLS CUI
- C0079399
- SNOMED CT 2010_0731
- 263495000
- LNC
- MTHU002975
Beskrivning
Healthy Subject
Datatyp
string
Alias
- UMLS CUI
- C1708335
Beskrivning
stuttering
Datatyp
string
Alias
- UMLS CUI
- C0038506
- MDR
- 10042267
- SNOMED CT 2010_0731
- 39423001
Beskrivning
Primary stuttering
Datatyp
string
Alias
- UMLS CUI
- C0454537
- SNOMED CT 2010_0731
- 229626005
Beskrivning
Right handed
Datatyp
string
Alias
- UMLS CUI
- C0344333
- SNOMED CT 2010_0731
- 46669005
Beskrivning
Hearing normal
Datatyp
string
Alias
- UMLS CUI
- C0234725
- SNOMED CT 2010_0731
- 162339002
Beskrivning
nervous system disorder
Datatyp
string
Alias
- UMLS CUI
- C0027765
- ICD10CM
- G00-G99
- ICD9CM
- 349.9
- MDR
- 10029202
- SNOMED CT 2010_0731
- 118940003
Beskrivning
Mental disorders
Datatyp
string
Alias
- UMLS CUI
- C0004936
- ICD10CM
- F01-F99
- ICD9CM
- 290-319.99
- MDR
- 10061284
- SNOMED CT 2010_0731
- 74732009
Beskrivning
Central Nervous System Agents
Datatyp
string
Alias
- UMLS CUI
- C0007680
- SNOMED CT 2010_0731
- 372752008
Beskrivning
Implant
Datatyp
string
Alias
- UMLS CUI
- C0021102
- SNOMED CT 2010_0731
- #####
Similar models
Eligibility
- StudyEvent: Eligibility
424144002 (SNOMED CT 2010_0731)
MTHU010047 (LNC)
263495000 (SNOMED CT 2010_0731)
MTHU002975 (LNC)
10042267 (MDR)
39423001 (SNOMED CT 2010_0731)
C0454537 (UMLS CUI)
229626005 (SNOMED CT 2010_0731)
46669005 (SNOMED CT 2010_0731)
162339002 (SNOMED CT 2010_0731)
G00-G99 (ICD10CM)
349.9 (ICD9CM)
10029202 (MDR)
118940003 (SNOMED CT 2010_0731)
F01-F99 (ICD10CM)
290-319.99 (ICD9CM)
10061284 (MDR)
74732009 (SNOMED CT 2010_0731)
372752008 (SNOMED CT 2010_0731)
##### (SNOMED CT 2010_0731)
424144002 (SNOMED CT 2010_0731)
MTHU010047 (LNC)
263495000 (SNOMED CT 2010_0731)
MTHU002975 (LNC)
10042267 (MDR)
39423001 (SNOMED CT 2010_0731)
229626005 (SNOMED CT 2010_0731)
46669005 (SNOMED CT 2010_0731)
162339002 (SNOMED CT 2010_0731)
G00-G99 (ICD10CM)
349.9 (ICD9CM)
10029202 (MDR)
118940003 (SNOMED CT 2010_0731)
F01-F99 (ICD10CM)
290-319.99 (ICD9CM)
10061284 (MDR)
74732009 (SNOMED CT 2010_0731)
372752008 (SNOMED CT 2010_0731)
##### (SNOMED CT 2010_0731)