Information:
Fel:
ID
4282
Beskrivning
The purpose of this Phase II study is to determine if AZD4877, an experimental drug that is a novel anti-mitotic agent (Eg5 or Kinesin Spindle Protein inhibitor that interferes with tumor cell division leading to tumor growth), can reduce tumor sizes in patients with bladder cancer
Nyckelord
Versioner (1)
- 2013-12-06 2013-12-06 - Martin Dugas
Uppladdad den
6 december 2013
DOI
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Licens
Creative Commons BY-NC 3.0 Legacy
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Eligibility DRKS00004052 NCT00661609 Advanced Bladder Cancer
Similar models
Eligibility
- StudyEvent: Eligibility
Name
Typ
Description | Question | Decode (Coded Value)
Datatyp
Alias
Confirmed urothelial cancer
Item
Confirmed urothelial cancer (cancer of the bladder, renal pelvis, ureter, or urethra).
boolean
CL363966 (NCI Metathesaurus CUI)
Disease stage
Item
Tumor, Node, Metastasis (TNM) Stage IV urothelial cancer that can not be helped by curative surgery and/or curative radiotherapy
boolean
C0474940 (NCI Metathesaurus CUI)
Chemotherapie
Item
Must have had a maximum of 2 prior chemotherapeutic regimens, one for unremovable and/or metastasized disease, and the other in the adjuvant or neo-adjuvant setting.
boolean
C1518470 (NCI Metathesaurus CUI)
Selfcare
Item
Ambulatory and capable of all selfcare more than 50% of waking hours
boolean
C0036592 (NCI Metathesaurus CUI)
Prior treatment
Item
Prior treatment with investigational or standard anti-cancer agents, including radiotherapy, within 4 weeks prior to first dose of study medication; 6 weeks if prior systemic mitomycin, nitrosourea, or suramin.
boolean
C1522449 (NCI Metathesaurus CUI)
C0949266 (NCI Metathesaurus CUI)
C0949266 (NCI Metathesaurus CUI)
Bone marrow
Item
Inadequate bone marrow reserve
boolean
C0005953 (NCI Metathesaurus CUI)
Liver function
Item
Inadequate liver function in the presence of liver metastases
boolean
C0232744 (NCI Metathesaurus CUI)
Renal function
Item
Impaired renal function
boolean
C0341697 (NCI Metathesaurus CUI)