Lesion High intensity Quantity T2/FLAIR MRI
Item
mri findings must reveal at least 2 hyperintense lesions on t2-wi or flair images at first clinical onset
boolean
C0221198 (UMLS CUI [1,1])
C4081854 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C3897397 (UMLS CUI [1,4])
Oligoclonal Bands Cerebrospinal fluid examination | Therapeutic procedure Attack
Item
csf examination should confirm oligoclonal bands (examination must be done in an internationally approved lab and the csf taken before the treatment of attack starts)
boolean
C4048246 (UMLS CUI [1,1])
C0430067 (UMLS CUI [1,2])
C0087111 (UMLS CUI [2,1])
C1304680 (UMLS CUI [2,2])
Age
Item
age 18 - 55 years
boolean
C0001779 (UMLS CUI [1])
Childbearing Potential Contraceptive methods
Item
effective contraception in female patients of childbearing potential
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
Kurtzke multiple sclerosis rating scale
Item
kurtzke edss ≤ 3.5 at baseline
boolean
C0451246 (UMLS CUI [1])
Protocol Compliance
Item
willingness to accept the plan of the study and compliance with the study
boolean
C0525058 (UMLS CUI [1])
Clinically isolated syndrome Symptoms First | Magnetic Resonance Imaging | Steroids
Item
time from the beginning of first symptoms of cis to baseline visit should not exceed 4 months (baseline mri and baseline visit will be organized first 28 days after last steroid administration)
boolean
C2921627 (UMLS CUI [1,1])
C1457887 (UMLS CUI [1,2])
C0205435 (UMLS CUI [1,3])
C0024485 (UMLS CUI [2])
C0038317 (UMLS CUI [3])
Clinically isolated syndrome Attack | Methylprednisolone Dose Without Medication taper
Item
cis attack is treated by at least 3g of methylprednisolone without taper
boolean
C2921627 (UMLS CUI [1,1])
C1304680 (UMLS CUI [1,2])
C0025815 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C0332288 (UMLS CUI [2,3])
C1827449 (UMLS CUI [2,4])
Attack Severe | Cyclophosphamide Dosage | Magnetic Resonance Imaging | Cerebrospinal fluid examination
Item
in case of severe attack 1 g of cyclophosphamide does not disqualify the patient from the study if first mri and csf examination was done before treatment administered
boolean
C1304680 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0010583 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C0024485 (UMLS CUI [3])
C0430067 (UMLS CUI [4])
Disease Organ Major Hepatic | Disease Organ Major Thyroid
Item
no active major organ disease especially of hepatic or thyroid origin
boolean
C0012634 (UMLS CUI [1,1])
C0178784 (UMLS CUI [1,2])
C0205164 (UMLS CUI [1,3])
C0205054 (UMLS CUI [1,4])
C0012634 (UMLS CUI [2,1])
C0178784 (UMLS CUI [2,2])
C0205164 (UMLS CUI [2,3])
C0040132 (UMLS CUI [2,4])
Multiple Sclerosis | Attack second
Item
the clinical diagnosis of ms is definite (the second attack occurs before the baseline visit)
boolean
C0026769 (UMLS CUI [1])
C1304680 (UMLS CUI [2,1])
C0205436 (UMLS CUI [2,2])
Age
Item
age less than 18 or more than 55
boolean
C0001779 (UMLS CUI [1])
Contraceptive methods Inadequate | Pregnancy, Planned
Item
non-effective contraception method or pregnancy planning
boolean
C0700589 (UMLS CUI [1,1])
C0205412 (UMLS CUI [1,2])
C0032992 (UMLS CUI [2])
Disease Organ Major Hepatic | Disease Organ Major endocrinologic
Item
active major organ disease, especially hepatic or endocrinologic
boolean
C0012634 (UMLS CUI [1,1])
C0178784 (UMLS CUI [1,2])
C0205164 (UMLS CUI [1,3])
C0205054 (UMLS CUI [1,4])
C0012634 (UMLS CUI [2,1])
C0178784 (UMLS CUI [2,2])
C0205164 (UMLS CUI [2,3])
C0694557 (UMLS CUI [2,4])
Compliance behavior Unsure
Item
cooperation of the subject cannot be ensured
boolean
C1321605 (UMLS CUI [1,1])
C0087130 (UMLS CUI [1,2])
Kurtzke multiple sclerosis rating scale
Item
kurtzke edss higher than 3.5 at baseline
boolean
C0451246 (UMLS CUI [1])