age at least 22 Years
Item
age at least 22 Years
boolean
C0001779 (UMLS CUI 2011AA)
397669002 (SNOMED CT 2011_0131)
Severe Chronic Heart Failure (CHF) with NYHA class III-IV or NYHA class II with at least one hospitalisation for HF within the last 24 months
Item
Severe Chronic Heart Failure (CHF) with NYHA class III-IV or NYHA class II with at least one hospitalisation for HF within the last 24 months
boolean
C0205082 (UMLS CUI 2011AA)
24484000 (SNOMED CT 2011_0131)
C0264716 (UMLS CUI 2011AA)
48447003 (SNOMED CT 2011_0131)
10008908 (MedDRA 14.1)
C0011900 (UMLS CUI 2011AA)
439401001 (SNOMED CT 2011_0131)
MTHU008876 (LOINC Version 232)
C1319795 (UMLS CUI 2011AA)
420913000 (SNOMED CT 2011_0131)
10064081 (MedDRA 14.1)
C1319796 (UMLS CUI 2011AA)
422293003 (SNOMED CT 2011_0131)
10064082 (MedDRA 14.1)
C1319794 (UMLS CUI 2011AA)
421704003 (SNOMED CT 2011_0131)
10064080 (MedDRA 14.1)
C0019993 (UMLS CUI 2011AA)
394656005 (SNOMED CT 2011_0131)
10054112 (MedDRA 14.1)
C0018801 (UMLS CUI 2011AA)
155374007 (SNOMED CT 2011_0131)
10019279 (MedDRA 14.1)
428 (ICD-9-CM Version 2011)
E10124 (CTCAE 1105E)
Left ventricular ejection fraction (LVEF) <= 45% by means of echocardiography, radionucleotide angiography, left ventriculography or cardiac MRI documented < 12 weeks before randomisation
Item
Left ventricular ejection fraction (LVEF) <= 45% by means of echocardiography, radionucleotide angiography, left ventriculography or cardiac MRI documented < 12 weeks before randomisation
boolean
C0428772 (UMLS CUI 2011AA)
250908004 (SNOMED CT 2011_0131)
10069170 (MedDRA 14.1)
C0013516 (UMLS CUI 2011AA)
40701008 (SNOMED CT 2011_0131)
10014116 (MedDRA 14.1)
88.72 (ICD-9-CM Version 2011)
C0034604 (UMLS CUI 2011AA)
C0412219 (UMLS CUI 2011AA)
265484009 (SNOMED CT 2011_0131)
10024122 (MedDRA 14.1)
C1522601 (UMLS CUI 2011AA)
C0024485 (UMLS CUI 2011AA)
113091000 (SNOMED CT 2011_0131)
10028049 (MedDRA 14.1)
Diagnosis of sleep disordered breathing (SDB) with an apnoea-hypopnoea-index (AHI) of >15/hr with at least 50% central events and a central AHI of at least 10/hr
Item
Diagnosis of sleep disordered breathing (SDB) with an apnoea-hypopnoea-index (AHI) of >15/hr with at least 50% central events and a central AHI of at least 10/hr
boolean
C0011900 (UMLS CUI 2011AA)
439401001 (SNOMED CT 2011_0131)
MTHU008876 (LOINC Version 232)
C0037315 (UMLS CUI 2011AA)
73430006 (SNOMED CT 2011_0131)
10040979 (MedDRA 14.1)
G47.30 (ICD-10-CM Version 2010)
780.57 (ICD-9-CM Version 2011)
E13566 (CTCAE 1105E)
C0003578 (UMLS CUI 2011AA)
1023001 (SNOMED CT 2011_0131)
10002974 (MedDRA 14.1)
R06.81 (ICD-10-CM Version 2010)
786.03 (ICD-9-CM Version 2011)
E13306 (CTCAE 1105E)
C0235546 (UMLS CUI 2011AA)
386614005 (SNOMED CT 2011_0131)
10021079 (MedDRA 14.1)
C0918012 (UMLS CUI 2011AA)
C0205099 (UMLS CUI 2011AA)
26216008 (SNOMED CT 2011_0131)
C0441471 (UMLS CUI 2011AA)
272379006 (SNOMED CT 2011_0131)
MTHU019184 (LOINC Version 232)
Clinically stable with no change in medication and no unplanned hospitalisation for heart failure in preceding month
Item
Clinically stable with no change in medication and no unplanned hospitalisation for heart failure in preceding month
boolean
C0205360 (UMLS CUI 2011AA)
58158008 (SNOMED CT 2011_0131)
MTHU015276 (LOINC Version 232)
C0013227 (UMLS CUI 2011AA)
C0332197 (UMLS CUI 2011AA)
2667000 (SNOMED CT 2011_0131)
C1518422 (UMLS CUI 2011AA)
C1301732 (UMLS CUI 2011AA)
397943006 (SNOMED CT 2011_0131)
C0019993 (UMLS CUI 2011AA)
394656005 (SNOMED CT 2011_0131)
10054112 (MedDRA 14.1)
C0018801 (UMLS CUI 2011AA)
155374007 (SNOMED CT 2011_0131)
10019279 (MedDRA 14.1)
428 (ICD-9-CM Version 2011)
E10124 (CTCAE 1105E)
Optimised medical treatment according to the applicable guidelines
Item
Optimised medical treatment according to the applicable guidelines
boolean
C2698650 (UMLS CUI 2011AA)
C0039798 (UMLS CUI 2011AA)
C0332290 (UMLS CUI 2011AA)
385433004 (SNOMED CT 2011_0131)
C1706839 (UMLS CUI 2011AA)
C0220845 (UMLS CUI 2011AA)
Able to provide informed consent
Item
Able to provide informed consent
boolean
C0021430 (UMLS CUI 2011AA)
Predominant central sleep apnoea (apnoea hypopnoea index > 15/hour with ≥ 50% central events and a central AHI ≥10/hour, derived from full polysomnography (based on total sleep time), documented < 4 weeks before randomization. Flow measurements have to be performed with nasal cannula
Item
Predominant central sleep apnoea (apnoea hypopnoea index > 15/hour with ≥ 50% central events and a central AHI ≥10/hour, derived from full polysomnography (based on total sleep time), documented < 4 weeks before randomization. Flow measurements have to be performed with nasal cannula
boolean
C0751762 (UMLS CUI 2011AA)
G47.31 (ICD-10-CM Version 2010)
327.21 (ICD-9-CM Version 2011)
C0003578 (UMLS CUI 2011AA)
1023001 (SNOMED CT 2011_0131)
10002974 (MedDRA 14.1)
R06.81 (ICD-10-CM Version 2010)
786.03 (ICD-9-CM Version 2011)
E13306 (CTCAE 1105E)
C0235546 (UMLS CUI 2011AA)
386614005 (SNOMED CT 2011_0131)
10021079 (MedDRA 14.1)
C0918012 (UMLS CUI 2011AA)
C0205099 (UMLS CUI 2011AA)
26216008 (SNOMED CT 2011_0131)
C0441471 (UMLS CUI 2011AA)
272379006 (SNOMED CT 2011_0131)
MTHU019184 (LOINC Version 232)
C0162701 (UMLS CUI 2011AA)
60554003 (SNOMED CT 2011_0131)
10053319 (MedDRA 14.1)
89.17 (ICD-9-CM Version 2011)
C0599318 (UMLS CUI 2011AA)
C0807070 (UMLS CUI 2011AA)
MTHU031476 (LOINC Version 232)
Significant chronic obstructive pulmonary disease (COPD) with Forced Expiratory Volume within one second (FEV1)<50% predicted
Item
Significant chronic obstructive pulmonary disease (COPD) with Forced Expiratory Volume within one second (FEV1)<50% predicted
boolean
C0024117 (UMLS CUI 2011AA)
13645005 (SNOMED CT 2011_0131)
10009033 (MedDRA 14.1)
J44.9 (ICD-10-CM Version 2010)
496 (ICD-9-CM Version 2011)
CL414841 (UMLS CUI 2011AA)
Oxygen saturation at rest during the day 90% at the time of inclusion
Item
Oxygen saturation at rest during the day 90% at the time of inclusion
boolean
C2923814 (UMLS CUI 2011AA)
59417-6 (LOINC Version 232)
C0585022 (UMLS CUI 2011AA)
307143006 (SNOMED CT 2011_0131)
Current use of Positive Airway Pressure (PAP) therapy
Item
Current use of Positive Airway Pressure (PAP) therapy
boolean
C1524063 (UMLS CUI 2011AA)
260676000 (SNOMED CT 2011_0131)
CL415097 (UMLS CUI 2011AA)
C0428719 (UMLS CUI 2011AA)
250852008 (SNOMED CT 2011_0131)
MTHU008125 (LOINC Version 232)
C0039798 (UMLS CUI 2011AA)
Life expectancy < 1 year for diseases unrelated to chronic heart failure
Item
Life expectancy < 1 year for diseases unrelated to chronic heart failure
boolean
C0023671 (UMLS CUI 2011AA)
LP75025-4 (LOINC Version 232)
C0439092 (UMLS CUI 2011AA)
276139006 (SNOMED CT 2011_0131)
LT (HL7 V3 2006_05)
C0205447 (UMLS CUI 2011AA)
38112003 (SNOMED CT 2011_0131)
C0439234 (UMLS CUI 2011AA)
258707000 (SNOMED CT 2011_0131)
Y (HL7 V3 2006_05)
C0012634 (UMLS CUI 2011AA)
64572001 (SNOMED CT 2011_0131)
CL414700 (UMLS CUI 2011AA)
C0264716 (UMLS CUI 2011AA)
48447003 (SNOMED CT 2011_0131)
10008908 (MedDRA 14.1)
Cardiac surgery, Percutaneous coronary intervention (PCI), Myocardial Infarction (MI) or unstable angina within 6 months prior to randomisation
Item
Cardiac surgery, Percutaneous coronary intervention (PCI), Myocardial Infarction (MI) or unstable angina within 6 months prior to randomisation
boolean
C0018821 (UMLS CUI 2011AA)
64915003 (SNOMED CT 2011_0131)
10061026 (MedDRA 14.1)
C1532338 (UMLS CUI 2011AA)
415070008 (SNOMED CT 2011_0131)
10065608 (MedDRA 14.1)
C0027051 (UMLS CUI 2011AA)
22298006 (SNOMED CT 2011_0131)
10028596 (MedDRA 14.1)
MTHU035551 (LOINC Version 232)
I21-I22 (ICD-10-CM Version 2010)
410 (ICD-9-CM Version 2011)
E10152 (CTCAE 1105E)
C0002965 (UMLS CUI 2011AA)
4557003 (SNOMED CT 2011_0131)
10002388 (MedDRA 14.1)
I20.0 (ICD-10-CM Version 2010)
411.1 (ICD-9-CM Version 2011)
Implantation of ICD (implanted cardiodefibrillator) or CRT (cardiac resynchronisation therapy) scheduled or within 6 months prior to randomisation
Item
Implantation of ICD (implanted cardiodefibrillator) or CRT (cardiac resynchronisation therapy) scheduled or within 6 months prior to randomisation
boolean
C0021107 (UMLS CUI 2011AA)
71861002 (SNOMED CT 2011_0131)
MTHU035917 (LOINC Version 232)
C0162589 (UMLS CUI 2011AA)
72506001 (SNOMED CT 2011_0131)
C1167956 (UMLS CUI 2011AA)
10059862 (MedDRA 14.1)
C0086960 (UMLS CUI 2011AA)
Transient ischemic attack (TIA) or Stroke within 3 months prior to randomisation
Item
Transient ischemic attack (TIA) or Stroke within 3 months prior to randomisation
boolean
C0007787 (UMLS CUI 2011AA)
266257000 (SNOMED CT 2011_0131)
10044390 (MedDRA 14.1)
MTHU020810 (LOINC Version 232)
G45.9 (ICD-10-CM Version 2010)
435.9 (ICD-9-CM Version 2011)
E12834 (CTCAE 1105E)
C0038454 (UMLS CUI 2011AA)
230690007 (SNOMED CT 2011_0131)
10042244 (MedDRA 14.1)
I63.9 (ICD-10-CM Version 2010)
E12826 (CTCAE 1105E)
Primary hemodynamically significant uncorrected valvular heart disease, obstructive or regurgitant, or any valvular disease expected to lead to surgery during the trial
Item
Primary hemodynamically significant uncorrected valvular heart disease, obstructive or regurgitant, or any valvular disease expected to lead to surgery during the trial
boolean
CL414904 (UMLS CUI 2011AA)
C0019010 (UMLS CUI 2011AA)
C0018824 (UMLS CUI 2011AA)
368009 (SNOMED CT 2011_0131)
10061406 (MedDRA 14.1)
C0028778 (UMLS CUI 2011AA)
26036001 (SNOMED CT 2011_0131)
10061876 (MedDRA 14.1)
C2004489 (UMLS CUI 2011AA)
78104003 (SNOMED CT 2011_0131)
10067171 (MedDRA 14.1)
C1399222 (UMLS CUI 2011AA)
C1517001 (UMLS CUI 2011AA)
C0038895 (UMLS CUI 2011AA)
Acute myocarditis/pericarditis within 6 months prior to randomisation
Item
Acute myocarditis/pericarditis within 6 months prior to randomisation
boolean
C0155686 (UMLS CUI 2011AA)
46701001 (SNOMED CT 2011_0131)
10000932 (MedDRA 14.1)
I40.9 (ICD-10-CM Version 2010)
422.90 (ICD-9-CM Version 2011)
C0155679 (UMLS CUI 2011AA)
15555002 (SNOMED CT 2011_0131)
10000996 (MedDRA 14.1)
I30 (ICD-10-CM Version 2010)
420 (ICD-9-CM Version 2011)
Untreated or therapy refractory Restless legs Syndrome (RLS)
Item
Untreated or therapy refractory Restless legs Syndrome (RLS)
boolean
C1518422 (UMLS CUI 2011AA)
CL415147 (UMLS CUI 2011AA)
C0205269 (UMLS CUI 2011AA)
20646008 (SNOMED CT 2011_0131)
C0035258 (UMLS CUI 2011AA)
32914008 (SNOMED CT 2011_0131)
10058920 (MedDRA 14.1)
G25.81 (ICD-10-CM Version 2010)
333.94 (ICD-9-CM Version 2011)
Pregnancy
Item
Pregnancy, Gestation
boolean
C0549206 (UMLS CUI 2011AA)
289908002 (SNOMED CT 2011_0131)
10036556 (MedDRA 14.1)
MTHU035048 (LOINC Version 232)
Amyloidosis, hypertrophic obstructive cardiomyopathy or arteriovenous fistulas
Item
Amyloidosis, hypertrophic obstructive cardiomyopathy or arteriovenous fistulas
boolean
C0002726 (UMLS CUI 2011AA)
17602002 (SNOMED CT 2011_0131)
10002022 (MedDRA 14.1)
E85 (LOINC Version 232)
277.3 (ICD-10-CM Version 2010)
C0700053 (UMLS CUI 2011AA)
360465008 (SNOMED CT 2011_0131)
10021230 (MedDRA 14.1)
I42.1 (ICD-10-CM Version 2010)
C0003855 (UMLS CUI 2011AA)
439470001 (SNOMED CT 2011_0131)
10003226 (MedDRA 14.1)
MTHU011026 (LOINC Version 232)
Dosage changes of diuretics more than doubled within the last 4 weeks prior to randomisation
Item
Dosage changes of diuretics more than doubled within the last 4 weeks prior to randomisation
boolean
C0012798 (UMLS CUI 2011AA)
372695000 (SNOMED CT 2011_0131)
MTHU003217 (LOINC Version 232)
C2347524 (UMLS CUI 2011AA)
C0439093 (UMLS CUI 2011AA)
276140008 (SNOMED CT 2011_0131)
GT (HL7 V3 2006_05)
C0205173 (UMLS CUI 2011AA)
1305003 (SNOMED CT 2011_0131)
C0439231 (UMLS CUI 2011AA)
258706009 (SNOMED CT 2011_0131)
MO (HL7 V3 2006_05)
C0332152 (UMLS CUI 2011AA)
288556008 (SNOMED CT 2011_0131)
C0034656 (UMLS CUI 2011AA)