age 12 Years to 35 Years
Item
age 12 Years to 35 Years
boolean
C0001779 (UMLS CUI 2011AA)
397669002 (SNOMED CT 2011_0131)
Males aged 12 - 35 years
Item
male, male gender
boolean
C0024554 (UMLS CUI 2011AA)
248153007 (SNOMED CT 2011_0131)
M (HL7 V3 2006_05)
Severe hemophilia A ( < 1 % FVIII:C)
Item
Severe hemophilia A ( < 1 % FVIII:C)
boolean
C0272322 (UMLS CUI 2011AA)
No history of Factor VIII inhibitory antibody
Item
No history of Factor VIII inhibitory antibody
boolean
C0332197 (UMLS CUI 2011AA)
2667000 (SNOMED CT 2011_0131)
CL421546 (UMLS CUI 2011AA)
392521001 (SNOMED CT 2011_0131)
C0368953 (UMLS CUI 2011AA)
58730008 (SNOMED CT 2011_0131)
MTHU014157 (LOINC Version 232)
For prophylaxis groups, having received at least two prophylactic infusions per week for 45 weeks per year for the prevention of bleeding without relevant interruption and continuing until the present.
Item
For prophylaxis groups, having received at least two prophylactic infusions per week for 45 weeks per year for the prevention of bleeding without relevant interruption and continuing until the present.
boolean
C0439091 (UMLS CUI 2011AA)
276138003 (SNOMED CT 2011_0131)
GE (HL7 V3 2006_05)
C0205448 (UMLS CUI 2011AA)
19338005 (SNOMED CT 2011_0131)
C0199176 (UMLS CUI 2011AA)
360271000 (SNOMED CT 2011_0131)
10036898 (MedDRA 14.1)
C0574032 (UMLS CUI 2011AA)
36576007 (SNOMED CT 2011_0131)
10060345 (MedDRA 14.1)
_Infusion (HL7 V3 2006_05)
C2700409 (UMLS CUI 2011AA)
C0019080 (UMLS CUI 2011AA)
50960005 (SNOMED CT 2011_0131)
10055798 (MedDRA 14.1)
R58 (ICD-10-CM Version 2010)
459.0 (ICD-9-CM Version 2011)
Complete documentation of joints bleeds and their locations prior to start of prophylaxis,
Item
Complete documentation of joints bleeds and their locations prior to start of prophylaxis,
boolean
C0920316 (UMLS CUI 2011AA)
C0018924 (UMLS CUI 2011AA)
81808003 (SNOMED CT 2011_0131)
10018829 (MedDRA 14.1)
M25.0 (ICD-10-CM Version 2010)
719.1 (ICD-9-CM Version 2011)
C0450429 (UMLS CUI 2011AA)
246267002 (SNOMED CT 2011_0131)
C0332152 (UMLS CUI 2011AA)
288556008 (SNOMED CT 2011_0131)
C0199176 (UMLS CUI 2011AA)
360271000 (SNOMED CT 2011_0131)
10036898 (MedDRA 14.1)
Bleeding history and/or treatments received during the last 5 years documented in the subjects medical records.
Item
Bleeding history and/or treatments received during the last 5 years documented in the subjects medical records.
boolean
CL421546 (UMLS CUI 2011AA)
392521001 (SNOMED CT 2011_0131)
C0019080 (UMLS CUI 2011AA)
50960005 (SNOMED CT 2011_0131)
10055798 (MedDRA 14.1)
R58 (ICD-10-CM Version 2010)
459.0 (ICD-9-CM Version 2011)
C0039798 (UMLS CUI 2011AA)
C1517741 (UMLS CUI 2011AA)
C0205451 (UMLS CUI 2011AA)
34001005 (SNOMED CT 2011_0131)
C0439234 (UMLS CUI 2011AA)
258707000 (SNOMED CT 2011_0131)
Y (HL7 V3 2006_05)
For the on-demand subjects > 12 bleeds/year in the last 5 years.
Item
For the on-demand subjects > 12 bleeds/year in the last 5 years.
boolean
C0679686 (UMLS CUI 2011AA)
C0439093 (UMLS CUI 2011AA)
276140008 (SNOMED CT 2011_0131)
GT (HL7 V3 2006_05)
C0205458 (UMLS CUI 2011AA)
82809009 (SNOMED CT 2011_0131)
C1970394 (UMLS CUI 2011AA)
C0439508 (UMLS CUI 2011AA)
259039008 (SNOMED CT 2011_0131)
Written informed consent by subject and parent/legal representative, if < 18 years
Item
Written informed consent by subject and parent/legal representative, if < 18 years
boolean
C0021430 (UMLS CUI 2011AA)
Individuals with other coagulopathies (e.g., von Willebrand disease)
Item
Individuals with other coagulopathies (e.g., von Willebrand disease)
boolean
C0205394 (UMLS CUI 2011AA)
74964007 (SNOMED CT 2011_0131)
C0005779 (UMLS CUI 2011AA)
64779008 (SNOMED CT 2011_0131)
10009802 (MedDRA 14.1)
D68.9 (ICD-10-CM Version 2010)
C0042974 (UMLS CUI 2011AA)
128105004 (SNOMED CT 2011_0131)
10047715 (MedDRA 14.1)
D68.0 (ICD-10-CM Version 2010)
286.4 (ICD-9-CM Version 2011)
HIV seropositive subjects
Item
HIV Seropositivity
boolean
C0019699 (UMLS CUI 2011AA)
165816005 (SNOMED CT 2011_0131)
10020188 (MedDRA 14.1)
Z21 (ICD-10-CM Version 2010)
Individuals for whom the most clinically severe joint is not one of the 4 index joints (ankle, knee)
Item
Individuals for whom the most clinically severe joint is not one of the 4 index joints (ankle, knee)
boolean
C0205210 (UMLS CUI 2011AA)
58147004 (SNOMED CT 2011_0131)
C0205082 (UMLS CUI 2011AA)
24484000 (SNOMED CT 2011_0131)
C0022417 (UMLS CUI 2011AA)
39352004 (SNOMED CT 2011_0131)
C1518422 (UMLS CUI 2011AA)
C0003086 (UMLS CUI 2011AA)
344001 (SNOMED CT 2011_0131)
C0022742 (UMLS CUI 2011AA)
304679005 (SNOMED CT 2011_0131)
MTHU002687 (LOINC Version 232)
HCV seropositive individuals who underwent interferon therapy during the last 12 months
Item
HCV seropositive individuals who underwent interferon therapy during the last 12 months
boolean
C0220847 (UMLS CUI 2011AA)
62944002 (SNOMED CT 2011_0131)
10019752 (MedDRA 14.1)
C0521143 (UMLS CUI 2011AA)
4879001 (SNOMED CT 2011_0131)
C0279030 (UMLS CUI 2011AA)
C1517741 (UMLS CUI 2011AA)
C0439234 (UMLS CUI 2011AA)
258707000 (SNOMED CT 2011_0131)
Y (HL7 V3 2006_05)
Joint replacement
Item
Arthroplasty, Replacement
boolean
C0185317 (UMLS CUI 2011AA)
61557004 (SNOMED CT 2011_0131)
10023227 (MedDRA 14.1)
For the on-demand treatment group, any period > 8 consecutive months having received >/= 50 IU per kg per week Factor VIII for the prevention of bleeding
Item
For the on-demand treatment group, any period > 8 consecutive months having received >/= 50 IU per kg per week Factor VIII for the prevention of bleeding
boolean
C0679686 (UMLS CUI 2011AA)
C1948053 (UMLS CUI 2011AA)
C0439093 (UMLS CUI 2011AA)
276140008 (SNOMED CT 2011_0131)
GT (HL7 V3 2006_05)
C0205454 (UMLS CUI 2011AA)
7319005 (SNOMED CT 2011_0131)
C0439231 (UMLS CUI 2011AA)
258706009 (SNOMED CT 2011_0131)
MO (HL7 V3 2006_05)
C1514756 (UMLS CUI 2011AA)
C0015506 (UMLS CUI 2011AA)
278910002, 259736008 (SNOMED CT 2011_0131)
MTHU009422 (LOINC Version 232)