Co-administration of Aptivus (tipranavir) with low dose Norvir (ritonavir), with active substances that are highly dependent on CYP3A for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening events is contraindicated. These active substances include antiarrhythmics (amiodarone, bepridil, quinidine), antihistamines (astemizole, terfenadine), ergot derivatives (dihydroergotamine, ergonovine, ergotamine, methylergonovine), gastrointestinal motility agents (cisapride), neuroleptics (pimozide, sertindole), sedatives/hypnotics (triazolam) and HMG-CoA reductase inhibitors (simvastatin and lovastatin). In addition, co-administration of Aptivus (tipranavir) with low dose Norvir (ritonavir), with drugs that are highly dependent on CYP2D6 for clearance, such as the antiarrhythmics flecainide and propafenone, is contraindicated.
Co-administration of Aptivus (tipranavir) with low dose Norvir (ritonavir), with active substances that are highly dependent on CYP3A for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening events is contraindicated. These active substances include antiarrhythmics (amiodarone, bepridil, quinidine), antihistamines (astemizole, terfenadine), ergot derivatives (dihydroergotamine, ergonovine, ergotamine, methylergonovine), gastrointestinal motility agents (cisapride), neuroleptics (pimozide, sertindole), sedatives/hypnotics (triazolam) and HMG-CoA reductase inhibitors (simvastatin and lovastatin). In addition, co-administration of Aptivus (tipranavir) with low dose Norvir (ritonavir), with drugs that are highly dependent on CYP2D6 for clearance, such as the antiarrhythmics flecainide and propafenone, is contraindicated.
C1444657 (UMLS CUI 2011AA)
410536001 (SNOMED CT 2011_0131)
CL415222 (UMLS CUI 2011AA)
C1533734 (UMLS CUI 2011AA)
416118004 (SNOMED CT 2011_0131)
C1612190 (UMLS CUI 2011AA)
C1708745 (UMLS CUI 2011AA)
C0292818 (UMLS CUI 2011AA)
386896009 (SNOMED CT 2011_0131)
MTHU013855 (LOINC Version 232)
C0205177 (UMLS CUI 2011AA)
55561003 (SNOMED CT 2011_0131)
C0013227 (UMLS CUI 2011AA)
C0205250 (UMLS CUI 2011AA)
75540009 (SNOMED CT 2011_0131)
C0851827 (UMLS CUI 2011AA)
371154000 (SNOMED CT 2011_0131)
C1413881 (UMLS CUI 2011AA)
C2825073 (UMLS CUI 2011AA)
CL414623 (UMLS CUI 2011AA)
C0683150 (UMLS CUI 2011AA)
C0332281 (UMLS CUI 2011AA)
47429007 (SNOMED CT 2011_0131)
C2826307 (UMLS CUI 2011AA)
C1610642 (UMLS CUI 2011AA)
440181000 (SNOMED CT 2011_0131)
C0332152 (UMLS CUI 2011AA)
288556008 (SNOMED CT 2011_0131)
C0205177 (UMLS CUI 2011AA)
55561003 (SNOMED CT 2011_0131)
C0013227 (UMLS CUI 2011AA)
C0332257 (UMLS CUI 2011AA)
55919000 (SNOMED CT 2011_0131)
C0003195 (UMLS CUI 2011AA)
67507000 (SNOMED CT 2011_0131)
C0002598 (UMLS CUI 2011AA)
372821002 (SNOMED CT 2011_0131)
MTHU004841 (LOINC Version 232)
C0005116 (UMLS CUI 2011AA)
372503006 (SNOMED CT 2011_0131)
C0034414 (UMLS CUI 2011AA)
372697008 (SNOMED CT 2011_0131)
MTHU005039 (LOINC Version 232)
C0003360 (UMLS CUI 2011AA)
372806008 (SNOMED CT 2011_0131)
MTHU003328 (LOINC Version 232)
C0699606 (UMLS CUI 2011AA)
387333002 (SNOMED CT 2011_0131)
MTHU002553 (LOINC Version 232)
C0085173 (UMLS CUI 2011AA)
387089004 (SNOMED CT 2011_0131)
MTHU003387 (LOINC Version 232)
C0870507 (UMLS CUI 2011AA)
C0012291 (UMLS CUI 2011AA)
387267005 (SNOMED CT 2011_0131)
C0014704 (UMLS CUI 2011AA)
126071000 (SNOMED CT 2011_0131)
C0014710 (UMLS CUI 2011AA)
395975005 (SNOMED CT 2011_0131)
MTHU024862 (LOINC Version 232)
C0025760 (UMLS CUI 2011AA)
126074008 (SNOMED CT 2011_0131)
MTHU007397 (LOINC Version 232)
C0017184 (UMLS CUI 2011AA)
C1254351 (UMLS CUI 2011AA)
C0072916 (UMLS CUI 2011AA)
387164008 (SNOMED CT 2011_0131)
MTHU012783 (LOINC Version 232)
C0040615 (UMLS CUI 2011AA)
10784006, 372482001 (SNOMED CT 2011_0131)
MTHU003337 (LOINC Version 232)
C0031935 (UMLS CUI 2011AA)
386848009 (SNOMED CT 2011_0131)
MTHU003380 (LOINC Version 232)
C0084528 (UMLS CUI 2011AA)
418732002 (SNOMED CT 2011_0131)
C0036557 (UMLS CUI 2011AA)
372614000 (SNOMED CT 2011_0131)
C0020591 (UMLS CUI 2011AA)
372585002 (SNOMED CT 2011_0131)
MTHU015316 (LOINC Version 232)
C0040879 (UMLS CUI 2011AA)
386984001 (SNOMED CT 2011_0131)
MTHU003366 (LOINC Version 232)
C0360714 (UMLS CUI 2011AA)
372912004 (SNOMED CT 2011_0131)
C0074554 (UMLS CUI 2011AA)
387584000 (SNOMED CT 2011_0131)
C0024027 (UMLS CUI 2011AA)
96303004 (SNOMED CT 2011_0131)
C1444657 (UMLS CUI 2011AA)
410536001 (SNOMED CT 2011_0131)
CL415222 (UMLS CUI 2011AA)
C1533734 (UMLS CUI 2011AA)
416118004 (SNOMED CT 2011_0131)
C1612190 (UMLS CUI 2011AA)
C1708745 (UMLS CUI 2011AA)
C0292818 (UMLS CUI 2011AA)
386896009 (SNOMED CT 2011_0131)
MTHU013855 (LOINC Version 232)
C0013227 (UMLS CUI 2011AA)
C0205250 (UMLS CUI 2011AA)
75540009 (SNOMED CT 2011_0131)
C0851827 (UMLS CUI 2011AA)
371154000 (SNOMED CT 2011_0131)
C1332830 (UMLS CUI 2011AA)
C2825073 (UMLS CUI 2011AA)
C0003195 (UMLS CUI 2011AA)
67507000 (SNOMED CT 2011_0131)
C0016229 (UMLS CUI 2011AA)
372751001 (SNOMED CT 2011_0131)
MTHU004259 (LOINC Version 232)
C0033429 (UMLS CUI 2011AA)
372910007 (SNOMED CT 2011_0131)
MTHU012323 (LOINC Version 232)