*COPD Cases:*
Item
*COPD Cases:*
boolean
C0024117 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
Inclusion CriteriaAge at Enrollment: 45 - 80 years
Item
Inclusion CriteriaAge at Enrollment: 45 - 80 years
boolean
C1512693 (UMLS CUI [1,1])
C1516879 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
Smoking history of = 10 pack-years
Item
Smoking history of = 10 pack-years
boolean
C1519384 (UMLS CUI [1,1])
C1277691 (UMLS CUI [1,2])
C0449788 (UMLS CUI [1,3])
Diagnosis of COPD Stages 2, 3 and 4 by GOLD criteria (post-bronchodilator FEV1/FVC < 0.70 and FEV1 < 80% predicted)
Item
Diagnosis of COPD Stages 2, 3 and 4 by GOLD criteria (post-bronchodilator FEV1/FVC < 0.70 and FEV1 < 80% predicted)
boolean
C0011900 (UMLS CUI [1,1])
C0024117 (UMLS CUI [1,2])
C0679228 (UMLS CUI [1,3])
C5204349 (UMLS CUI [1,4])
Non-Hispanic White or non-Hispanic African American
Item
Non-Hispanic White or non-Hispanic African American
boolean
C1518424 (UMLS CUI [1,1])
C0085756 (UMLS CUI [1,2])
C0007457 (UMLS CUI [1,3])
Exclusion CriteriaConcomitant respiratory disorder other than asthma or COPD (such as, but not limited to, diffuse bronchiectasis, cystic fibrosis, or interstitial lung disease)
Item
Exclusion CriteriaConcomitant respiratory disorder other than asthma or COPD (such as, but not limited to, diffuse bronchiectasis, cystic fibrosis, or interstitial lung disease)
boolean
C0680251 (UMLS CUI [1,1])
C0243087 (UMLS CUI [1,2])
C0024115 (UMLS CUI [1,3])
C4723751 (UMLS CUI [1,4])
C0024117 (UMLS CUI [1,5])
C0004096 (UMLS CUI [1,6])
Lung surgery with removal of a lobe or more (including lung volume reduction surgery or lung transplantation)
Item
Lung surgery with removal of a lobe or more (including lung volume reduction surgery or lung transplantation)
boolean
C0038903 (UMLS CUI [1,1])
C0189497 (UMLS CUI [1,2])
C0524689 (UMLS CUI [1,3])
C0024128 (UMLS CUI [1,4])
Lung cancer, known or suspected
Item
Lung cancer, known or suspected
boolean
C0242379 (UMLS CUI [1,1])
C0277540 (UMLS CUI [1,2])
C0011900 (UMLS CUI [1,3])
Surgical or bronchoscopic lung volume reduction
Item
Surgical or bronchoscopic lung volume reduction
boolean
C0524689 (UMLS CUI [1,1])
C3697654 (UMLS CUI [1,2])
Pregnancy or suspected pregnancy
Item
Pregnancy or suspected pregnancy
boolean
C0032961 (UMLS CUI [1,1])
C5670366 (UMLS CUI [1,2])
Uncontrolled cancer, defined as ongoing radiation therapy, ongoing chemotherapy, narcotics for pain control, or known metastatic disease
Item
Uncontrolled cancer, defined as ongoing radiation therapy, ongoing chemotherapy, narcotics for pain control, or known metastatic disease
boolean
C0006826 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0549178 (UMLS CUI [1,3])
C1522449 (UMLS CUI [1,4])
C0392920 (UMLS CUI [1,5])
C0027627 (UMLS CUI [1,6])
C3898936 (UMLS CUI [1,7])
History of radiation therapy to the chest (other than for breast cancer)
Item
History of radiation therapy to the chest (other than for breast cancer)
boolean
C0262926 (UMLS CUI [1,1])
C1522449 (UMLS CUI [1,2])
C0817096 (UMLS CUI [1,3])
C4723751 (UMLS CUI [1,4])
C0678222 (UMLS CUI [1,5])
Use of antibiotics and/or systemic steroids (new prescription or increased dose) for a COPD exacerbation or respiratory infection within the last month
Item
Use of antibiotics and/or systemic steroids (new prescription or increased dose) for a COPD exacerbation or respiratory infection within the last month
boolean
C1524063 (UMLS CUI [1,1])
C0003232 (UMLS CUI [1,2])
C2825233 (UMLS CUI [1,3])
C0740304 (UMLS CUI [1,4])
C0035243 (UMLS CUI [1,5])
C1948053 (UMLS CUI [1,6])
C4331910 (UMLS CUI [1,7])
Inability to use albuterol
Item
Inability to use albuterol
boolean
C1299582 (UMLS CUI [1,1])
C1524063 (UMLS CUI [1,2])
C0001927 (UMLS CUI [1,3])
First or second degree relative (parent, brother, sister, daughter, son, aunt, uncle, nephew, niece, half-sibling, grandparent, grandchild) of a subject enrolled in COPDGene
Item
First or second degree relative (parent, brother, sister, daughter, son, aunt, uncle, nephew, niece, half-sibling, grandparent, grandchild) of a subject enrolled in COPDGene
boolean
C1517194 (UMLS CUI [1,1])
C1519210 (UMLS CUI [1,2])
C0337514 (UMLS CUI [1,3])
C0337527 (UMLS CUI [1,4])
C0337576 (UMLS CUI [1,5])
C0337577 (UMLS CUI [1,6])
C0337471 (UMLS CUI [1,7])
C0337548 (UMLS CUI [1,8])
C0337505 (UMLS CUI [1,9])
C1553703 (UMLS CUI [1,10])
C0030551 (UMLS CUI [1,11])
C0008059 (UMLS CUI [1,12])
C5419021 (UMLS CUI [1,13])
Subjects who indicate they are in more than one racial category
Item
Subjects who indicate they are in more than one racial category
boolean
C3146298 (UMLS CUI [1,1])
C0034510 (UMLS CUI [1,2])
C5142998 (UMLS CUI [1,3])
Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, or metal shoulder prosthesis
Item
Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, or metal shoulder prosthesis
boolean
C2984008 (UMLS CUI [1,1])
C0040405 (UMLS CUI [1,2])
C2240369 (UMLS CUI [1,3])
C4270802 (UMLS CUI [1,4])
C1385346 (UMLS CUI [1,5])
C0493002 (UMLS CUI [1,6])
Subjects with affirmative answers to the following:
Item
Subjects with affirmative answers to the following:
boolean
C0681799 (UMLS CUI [1,1])
C1706817 (UMLS CUI [1,2])
C1446409 (UMLS CUI [1,3])
chest or abdominal surgery in the past three months
Item
chest or abdominal surgery in the past three months
boolean
C0524832 (UMLS CUI [1,1])
C0198482 (UMLS CUI [1,2])
C4086725 (UMLS CUI [1,3])
a heart attack in the last three months
Item
a heart attack in the last three months
boolean
C0027051 (UMLS CUI [1,1])
C4086725 (UMLS CUI [1,2])
detached retina or eye surgery in the past three months
Item
detached retina or eye surgery in the past three months
boolean
C0035305 (UMLS CUI [1,1])
C0038901 (UMLS CUI [1,2])
C4086725 (UMLS CUI [1,3])
hospitalization for any other heart problem in the past month
Item
hospitalization for any other heart problem in the past month
boolean
C0019993 (UMLS CUI [1,1])
C0795691 (UMLS CUI [1,2])
C4331910 (UMLS CUI [1,3])
Participation in the ECLIPSE study, Boston Early-Onset COPD Study, or International COPD Genetics Network (Selected replication cohorts)
Item
Participation in the ECLIPSE study, Boston Early-Onset COPD Study, or International COPD Genetics Network (Selected replication cohorts)
boolean
C2348568 (UMLS CUI [1,1])
C0947630 (UMLS CUI [1,2])
C0024117 (UMLS CUI [1,3])
*Smokers without COPD:*
Item
*Smokers without COPD:*
boolean
C0337664 (UMLS CUI [1,1])
C0332288 (UMLS CUI [1,2])
C0024117 (UMLS CUI [1,3])
Inclusion CriteriaAge at Enrollment: 45 - 80 years
Item
Inclusion CriteriaAge at Enrollment: 45 - 80 years
boolean
C1512693 (UMLS CUI [1,1])
C1516879 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C1442880 (UMLS CUI [1,4])
History (current or former) of cigarette smoking = 10 pack-years
Item
History (current or former) of cigarette smoking = 10 pack-years
boolean
C1519384 (UMLS CUI [1,1])
C1277691 (UMLS CUI [1,2])
Post-bronchodilator FEV1/FVC = 0.70 and FEV1 = 80% predicted
Item
Post-bronchodilator FEV1/FVC = 0.70 and FEV1 = 80% predicted
boolean
C5204349 (UMLS CUI [1,1])
C0849974 (UMLS CUI [1,2])
Non-Hispanic White or non-Hispanic African American
Item
Non-Hispanic White or non-Hispanic African American
boolean
C1518424 (UMLS CUI [1,1])
C0085756 (UMLS CUI [1,2])
C0007457 (UMLS CUI [1,3])
Exclusion CriteriaPhysician diagnosed respiratory disease other than COPD or asthma (based on subject report)
Item
Exclusion CriteriaPhysician diagnosed respiratory disease other than COPD or asthma (based on subject report)
boolean
C0680251 (UMLS CUI [1,1])
C0011900 (UMLS CUI [1,2])
C0031831 (UMLS CUI [1,3])
C4723751 (UMLS CUI [1,4])
C0004096 (UMLS CUI [1,5])
C0024117 (UMLS CUI [1,6])
Lung surgery with removal of a lobe or more (including lung volume reduction surgery and lung transplantation)
Item
Lung surgery with removal of a lobe or more (including lung volume reduction surgery and lung transplantation)
boolean
C0038903 (UMLS CUI [1,1])
C0189497 (UMLS CUI [1,2])
C0524689 (UMLS CUI [1,3])
C0024128 (UMLS CUI [1,4])
Pregnancy or suspected pregnancy
Item
Pregnancy or suspected pregnancy
boolean
C0032961 (UMLS CUI [1,1])
C5670366 (UMLS CUI [1,2])
Lung cancer, known or suspected
Item
Lung cancer, known or suspected
boolean
C0242379 (UMLS CUI [1,1])
C0277540 (UMLS CUI [1,2])
C0011900 (UMLS CUI [1,3])
Uncontrolled cancer, defined as ongoing radiation therapy, ongoing chemotherapy, narcotics for pain control, or known metastatic disease
Item
Uncontrolled cancer, defined as ongoing radiation therapy, ongoing chemotherapy, narcotics for pain control, or known metastatic disease
boolean
C0006826 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0549178 (UMLS CUI [1,3])
C1522449 (UMLS CUI [1,4])
C0392920 (UMLS CUI [1,5])
C0027627 (UMLS CUI [1,6])
C3898936 (UMLS CUI [1,7])
History of radiation therapy to the chest
Item
History of radiation therapy to the chest
boolean
C0262926 (UMLS CUI [1,1])
C1522449 (UMLS CUI [1,2])
C0817096 (UMLS CUI [1,3])
Use of antibiotics (new prescription or increased dose) for a respiratory infection within the past month
Item
Use of antibiotics (new prescription or increased dose) for a respiratory infection within the past month
boolean
C1524063 (UMLS CUI [1,1])
C0003232 (UMLS CUI [1,2])
C2825233 (UMLS CUI [1,3])
C0740304 (UMLS CUI [1,4])
C0035243 (UMLS CUI [1,5])
C1948053 (UMLS CUI [1,6])
C4331910 (UMLS CUI [1,7])
Use of systemic corticosteroids (new prescription or increased dose) for a respiratory process within the past month
Item
Use of systemic corticosteroids (new prescription or increased dose) for a respiratory process within the past month
boolean
C1524063 (UMLS CUI [1,1])
C0003232 (UMLS CUI [1,2])
C2825233 (UMLS CUI [1,3])
C1948053 (UMLS CUI [1,4])
C4331910 (UMLS CUI [1,5])
Inability to use albuterol
Item
Inability to use albuterol
boolean
C1299582 (UMLS CUI [1,1])
C1524063 (UMLS CUI [1,2])
C0001927 (UMLS CUI [1,3])
First or second degree relative (parent, brother, sister, daughter, son, aunt, uncle, nephew, niece, half-sibling, grandparent, or grandchild) of a subject enrolled in COPDGene
Item
First or second degree relative (parent, brother, sister, daughter, son, aunt, uncle, nephew, niece, half-sibling, grandparent, or grandchild) of a subject enrolled in COPDGene
boolean
C1517194 (UMLS CUI [1,1])
C1519210 (UMLS CUI [1,2])
C0337514 (UMLS CUI [1,3])
C0337527 (UMLS CUI [1,4])
C0337576 (UMLS CUI [1,5])
C0337577 (UMLS CUI [1,6])
C0337471 (UMLS CUI [1,7])
C0337548 (UMLS CUI [1,8])
C0337505 (UMLS CUI [1,9])
C1553703 (UMLS CUI [1,10])
C0030551 (UMLS CUI [1,11])
C0008059 (UMLS CUI [1,12])
C5419021 (UMLS CUI [1,13])
Subjects who indicate they are in more than one racial category
Item
Subjects who indicate they are in more than one racial category
boolean
C3146298 (UMLS CUI [1,1])
C0034510 (UMLS CUI [1,2])
C5142998 (UMLS CUI [1,3])
Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, or metal shoulder prosthesis
Item
Metal objects that may interfere with chest CT quantification including presence of a cardiac pacemaker, defibrillator, metal prosthetic heart valve, or metal shoulder prosthesis
boolean
C2984008 (UMLS CUI [1,1])
C0040405 (UMLS CUI [1,2])
C2240369 (UMLS CUI [1,3])
C4270802 (UMLS CUI [1,4])
C1385346 (UMLS CUI [1,5])
C0493002 (UMLS CUI [1,6])
Subjects with affirmative answers to the following:
Item
Subjects with affirmative answers to the following:
boolean
C0681799 (UMLS CUI [1,1])
C1706817 (UMLS CUI [1,2])
C1446409 (UMLS CUI [1,3])
chest or abdominal surgery in the past three months
Item
chest or abdominal surgery in the past three months
boolean
C0524832 (UMLS CUI [1,1])
C0198482 (UMLS CUI [1,2])
C4086725 (UMLS CUI [1,3])
a heart attack in the last three months
Item
a heart attack in the last three months
boolean
C0027051 (UMLS CUI [1,1])
C4086725 (UMLS CUI [1,2])
detached retina or eye surgery in the past three months
Item
detached retina or eye surgery in the past three months
boolean
C0035305 (UMLS CUI [1,1])
C0038901 (UMLS CUI [1,2])
C4086725 (UMLS CUI [1,3])
hospitalization for any other heart problem in the past month
Item
hospitalization for any other heart problem in the past month
boolean
C0019993 (UMLS CUI [1,1])
C0795691 (UMLS CUI [1,2])
C4331910 (UMLS CUI [1,3])
Participation in the ECLIPSE study, Boston Early-Onset COPD Study, or International COPD Genetics Network (Selected replication cohorts)
Item
Participation in the ECLIPSE study, Boston Early-Onset COPD Study, or International COPD Genetics Network (Selected replication cohorts)
boolean
C2348568 (UMLS CUI [1,1])
C0947630 (UMLS CUI [1,2])
C0024117 (UMLS CUI [1,3])
*Note that similar enrollment criteria were utilized for lifelong nonsmoking control subjects.*
Item
*Note that similar enrollment criteria were utilized for lifelong nonsmoking control subjects.*
boolean
C1516879 (UMLS CUI [1,1])
C2348205 (UMLS CUI [1,2])
C0425293 (UMLS CUI [1,3])
C0009932 (UMLS CUI [1,4])