COGA recruited patients who were currently in a psychiatric inpatient or outpatient program for alcohol and/or chemical dependency. Detoxification must be complete before approaching the individual.
Item
COGA recruited patients who were currently in a psychiatric inpatient or outpatient program for alcohol and/or chemical dependency. Detoxification must be complete before approaching the individual.
boolean
C2949735 (UMLS CUI [1,1])
C0033873 (UMLS CUI [1,2])
C0029921 (UMLS CUI [1,3])
C0021562 (UMLS CUI [1,4])
C2919052 (UMLS CUI [1,5])
C0150543 (UMLS CUI [2,1])
C0205197 (UMLS CUI [2,2])
A potential proband: must not have used intravenous drugs more than 30 times lifetime and not within six months of screening, must not have any life-threatening illness other than alcohol-related terminal illnesses such as cirrhosis or Korsakoff's, must not be infected with the HIV virus, and his/her first-degree relatives must speak English, and live within one of the following six COGA catchment areas:
Item
A potential proband: must not have used intravenous drugs more than 30 times lifetime and not within six months of screening, must not have any life-threatening illness other than alcohol-related terminal illnesses such as cirrhosis or Korsakoff's, must not be infected with the HIV virus, and his/her first-degree relatives must speak English, and live within one of the following six COGA catchment areas:
boolean
C1948021 (UMLS CUI [1,1])
C3245505 (UMLS CUI [1,2])
C2242868 (UMLS CUI [1,3])
C1518422 (UMLS CUI [1,4])
C0449809 (UMLS CUI [1,5])
C0332168 (UMLS CUI [1,6])
C1948021 (UMLS CUI [2,1])
C3245505 (UMLS CUI [2,2])
C2986417 (UMLS CUI [2,3])
C3846017 (UMLS CUI [2,4])
C0332300 (UMLS CUI [2,5])
C0236664 (UMLS CUI [2,6])
C0679247 (UMLS CUI [2,7])
C0349464 (UMLS CUI [2,8])
C0023890 (UMLS CUI [2,9])
C1948021 (UMLS CUI [3,1])
C3245505 (UMLS CUI [3,2])
C2986417 (UMLS CUI [3,3])
C0019693 (UMLS CUI [3,4])
C1948021 (UMLS CUI [4,1])
C3245505 (UMLS CUI [4,2])
C1517194 (UMLS CUI [4,3])
C0581906 (UMLS CUI [4,4])
C0681784 (UMLS CUI [4,5])
C0237096 (UMLS CUI [4,6])
Each COGA site recruited control families consisting of two living parents and three or more full siblings, aged 14 or older. The control probands and families were ascertained via random consecutive sampling from either HMOs or dental clinics. They were representative of the general population and did not have to be unaffected individuals. Therefore, a control family would not be eliminated if alcoholism was present among any of its members.
Item
Each COGA site recruited control families consisting of two living parents and three or more full siblings, aged 14 or older. The control probands and families were ascertained via random consecutive sampling from either HMOs or dental clinics. They were representative of the general population and did not have to be unaffected individuals. Therefore, a control family would not be eliminated if alcoholism was present among any of its members.
boolean
C2825164 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C0015576 (UMLS CUI [1,3])
C0449961 (UMLS CUI [1,4])
C0030551 (UMLS CUI [1,5])
C0557094 (UMLS CUI [1,6])
C0001779 (UMLS CUI [1,7])
C1948021 (UMLS CUI [2,1])
C0015576 (UMLS CUI [2,2])
C0150105 (UMLS CUI [2,3])
C0018720 (UMLS CUI [2,4])
C0011344 (UMLS CUI [2,5])
C1882932 (UMLS CUI [3,1])
C0683971 (UMLS CUI [3,2])
C0522476 (UMLS CUI [3,3])
C2986417 (UMLS CUI [3,4])
We extended families through all affected, alive and dead, which means the standard protocol was administered to all first-degree relatives of all affected members. If any of these relatives was affected, we extended to his/her first-degree relatives, and continued if any of them was affected. In addition, extension by leapfrogging over a living or dead unaffected went to a branch containing at least two first-degree "leapfrog" relatives who had 3 implications by history.
Item
We extended families through all affected, alive and dead, which means the standard protocol was administered to all first-degree relatives of all affected members. If any of these relatives was affected, we extended to his/her first-degree relatives, and continued if any of them was affected. In addition, extension by leapfrogging over a living or dead unaffected went to a branch containing at least two first-degree "leapfrog" relatives who had 3 implications by history.
boolean
C1704788 (UMLS CUI [1,1])
C0015576 (UMLS CUI [1,2])
C1517194 (UMLS CUI [1,3])
C1546956 (UMLS CUI [1,4])
C2584946 (UMLS CUI [1,5])
C2599718 (UMLS CUI [1,6])
C0809949 (UMLS CUI [1,7])
C0080103 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C0439792 (UMLS CUI [2,3])
C2348561 (UMLS CUI [2,4])
C1517194 (UMLS CUI [2,5])
C0560435 (UMLS CUI [3,1])
C0237401 (UMLS CUI [3,2])
C2348562 (UMLS CUI [3,3])
C0262926 (UMLS CUI [3,4])