*Control donor lung exclusion criteria: *
Item
*Control donor lung exclusion criteria: *
boolean
C0680251 (UMLS CUI [1,1])
C2242763 (UMLS CUI [1,2])
C0009932 (UMLS CUI [1,3])
Unused donor lungs were not considered for study if the following criteria were met: <ol type="1">
Item
Unused donor lungs were not considered for study if the following criteria were met: <ol type="1">
boolean
C0445107 (UMLS CUI [1,1])
C5551647 (UMLS CUI [1,2])
C0680251 (UMLS CUI [1,3])
Lungs from donors ≥ 65 years old (no lower age limit)
Item
Lungs from donors ≥ 65 years old (no lower age limit)
boolean
C0001779 (UMLS CUI [1,1])
C2242763 (UMLS CUI [1,2])
Lungs from donors with arterial blood gas results showing a PaO2/FiO2 ratio of <300 mmHg (the donor should be mechanically ventilated using a conventional ventilator mode with positive end-expiratory pressure of ≤ 8 mm Hg.)
Item
Lungs from donors with arterial blood gas results showing a PaO2/FiO2 ratio of <300 mmHg (the donor should be mechanically ventilated using a conventional ventilator mode with positive end-expiratory pressure of ≤ 8 mm Hg.)
boolean
C5551647 (UMLS CUI [1,1])
C0024109 (UMLS CUI [1,2])
C0150411 (UMLS CUI [1,3])
C1696484 (UMLS CUI [1,4])
C0199470 (UMLS CUI [1,5])
C2223979 (UMLS CUI [1,6])
C0032740 (UMLS CUI [1,7])
Lungs from donors who are seropositive for HIV, HCV or HBV (Hepatitis B surface antigen).
Item
Lungs from donors who are seropositive for HIV, HCV or HBV (Hepatitis B surface antigen).
boolean
C0029206 (UMLS CUI [1,1])
C0024109 (UMLS CUI [1,2])
C0019699 (UMLS CUI [1,3])
C0019196 (UMLS CUI [1,4])
C0019169 (UMLS CUI [1,5])
C0521143 (UMLS CUI [1,6])
Lungs from donors who are high risk for HIV, HCV or HBV infections (e.g., known history of intravenous drug abuse and/or other high-risk behavior).
Item
Lungs from donors who are high risk for HIV, HCV or HBV infections (e.g., known history of intravenous drug abuse and/or other high-risk behavior).
boolean
C0024109 (UMLS CUI [1,1])
C0029206 (UMLS CUI [1,2])
C4319571 (UMLS CUI [1,3])
C0019693 (UMLS CUI [1,4])
C0019163 (UMLS CUI [1,5])
C0019196 (UMLS CUI [1,6])
C0262926 (UMLS CUI [1,7])
C0086181 (UMLS CUI [1,8])
C1171309 (UMLS CUI [1,9])
Lungs from donors with a history of amphetamine/methamphetamine use
Item
Lungs from donors with a history of amphetamine/methamphetamine use
boolean
C0024109 (UMLS CUI [1,1])
C0029206 (UMLS CUI [1,2])
C0262926 (UMLS CUI [1,3])
C0805080 (UMLS CUI [1,4])
C0013146 (UMLS CUI [1,5])
Lungs noted to have gross aspiration/infiltrates involving both lungs on chest radiographs (unless the infiltrates are due to volume overload and these infiltrates resolved with diuresis.)
Item
Lungs noted to have gross aspiration/infiltrates involving both lungs on chest radiographs (unless the infiltrates are due to volume overload and these infiltrates resolved with diuresis.)
boolean
C0024109 (UMLS CUI [1,1])
C0332448 (UMLS CUI [1,2])
C1720922 (UMLS CUI [1,3])
C3842377 (UMLS CUI [1,4])
C0546817 (UMLS CUI [1,5])
C0151225 (UMLS CUI [1,6])
C3714811 (UMLS CUI [1,7])
C0012797 (UMLS CUI [1,8])
Lungs from donors who have received massive transfusion (≥10 units of packed red blood cells, 10 units of fresh frozen plasma or 10 units of platelets.
Item
Lungs from donors who have received massive transfusion (≥10 units of packed red blood cells, 10 units of fresh frozen plasma or 10 units of platelets.
boolean
C0024109 (UMLS CUI [1,1])
C0029206 (UMLS CUI [1,2])
C0456675 (UMLS CUI [1,3])
C2316467 (UMLS CUI [1,4])
C0016709 (UMLS CUI [1,5])
C0086818 (UMLS CUI [1,6])
Lungs with unexpected pulmonary problems such as significant emphysema or pulmonary fibrosis noted on radiographic studies or significant pulmonary hypertension (right ventricular dilatation and/or estimated systolic pulmonary arterial pressure ≤45 mmHg) noted on echocardiography
Item
Lungs with unexpected pulmonary problems such as significant emphysema or pulmonary fibrosis noted on radiographic studies or significant pulmonary hypertension (right ventricular dilatation and/or estimated systolic pulmonary arterial pressure ≤45 mmHg) noted on echocardiography
boolean
C0024109 (UMLS CUI [1,1])
C0740941 (UMLS CUI [1,2])
C4055646 (UMLS CUI [1,3])
C0034067 (UMLS CUI [1,4])
C0034069 (UMLS CUI [1,5])
C0043299 (UMLS CUI [1,6])
C0020542 (UMLS CUI [1,7])
C0344893 (UMLS CUI [1,8])
C0428643 (UMLS CUI [1,9])
C0750572 (UMLS CUI [1,10])
C0013516 (UMLS CUI [1,11])
Lung from donors who have a smoking history of ≥ 50 pack-years.
Item
Lung from donors who have a smoking history of ≥ 50 pack-years.
boolean
C0024109 (UMLS CUI [1,1])
C0029206 (UMLS CUI [1,2])
C1519384 (UMLS CUI [1,3])
C1277691 (UMLS CUI [1,4])
Hospitalization for >7 days. - *If lungs from cardiac death donors, further exclusion criteria apply.*
Item
Hospitalization for >7 days. - *If lungs from cardiac death donors, further exclusion criteria apply.*
boolean
C0019993 (UMLS CUI [1,1])
C0449238 (UMLS CUI [1,2])
C0376297 (UMLS CUI [1,3])
C0029206 (UMLS CUI [1,4])
C0680251 (UMLS CUI [1,5])
C1517331 (UMLS CUI [1,6])
Infiltrates on the last chest x-ray (this X-ray must be taken within 24 hrs of donor's death.)
Item
Infiltrates on the last chest x-ray (this X-ray must be taken within 24 hrs of donor's death.)
boolean
C0239018 (UMLS CUI [1,1])
C0449238 (UMLS CUI [1,2])
C0332152 (UMLS CUI [1,3])
C1301931 (UMLS CUI [1,4])
Fever >38.2°C (100.7°F) within 24 hrs of donor' demise
Item
Fever >38.2°C (100.7°F) within 24 hrs of donor' demise
boolean
C0015967 (UMLS CUI [1,1])
C0449238 (UMLS CUI [1,2])
C0332152 (UMLS CUI [1,3])
C0011065 (UMLS CUI [1,4])
Lungs harvested >60 min after donor's demise
Item
Lungs harvested >60 min after donor's demise
boolean
C0396602 (UMLS CUI [1,1])
C0687676 (UMLS CUI [1,2])
C0011065 (UMLS CUI [1,3])
C0449238 (UMLS CUI [1,4])
*Case inclusion criteria* <ol type="1">
Item
*Case inclusion criteria* <ol type="1">
boolean
C1512693 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
Diagnosis of idiopathic or familial pulmonary arterial hypertension
Item
Diagnosis of idiopathic or familial pulmonary arterial hypertension
boolean
C0011900 (UMLS CUI [1,1])
C3203102 (UMLS CUI [1,2])
C1701939 (UMLS CUI [1,3])
Consent for donation
Item
Consent for donation
boolean
C0021430 (UMLS CUI [1,1])
C1318453 (UMLS CUI [1,2])
Age 18-65 years
Item
Age 18-65 years
boolean
C0001779 (UMLS CUI [1,1])