Probands for the IRAS Family Study were generally recruited from the parent IRAS study. Criteria for selection were based on reported family size but not on affection (diabetes) status. The minimum pedigree structure to be considered potentially eligible included four full siblings and five natural children. Individual family members were excluded if they were adopted or were less than 18 years of age.
Item
Probands for the IRAS Family Study were generally recruited from the parent IRAS study. Criteria for selection were based on reported family size but not on affection (diabetes) status. The minimum pedigree structure to be considered potentially eligible included four full siblings and five natural children. Individual family members were excluded if they were adopted or were less than 18 years of age.
boolean
C1948021 (UMLS CUI [1,1])
C0199236 (UMLS CUI [1,2])
C2949735 (UMLS CUI [1,3])
C0242801 (UMLS CUI [2,1])
C0015611 (UMLS CUI [2,2])
C0392760 (UMLS CUI [2,3])
C0011849 (UMLS CUI [2,4])
C0030761 (UMLS CUI [3,1])
C0013893 (UMLS CUI [3,2])
C2348717 (UMLS CUI [3,3])
C0337540 (UMLS CUI [3,4])
C1265611 (UMLS CUI [3,5])
C0680251 (UMLS CUI [4,1])
C0086282 (UMLS CUI [4,2])
C0337541 (UMLS CUI [4,3])
C0001779 (UMLS CUI [4,4])
In addition, individuals were excluded from participation in particular components of the protocol if they were deemed to have conditions which would place the participant at undue risk, interfere with the measurement of insulin resistance, or jeopardize the validity of self-reported data. Presence of these conditions resulted in complete exclusion or partial exams. These conditions included:Current insulin treatment
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In addition, individuals were excluded from participation in particular components of the protocol if they were deemed to have conditions which would place the participant at undue risk, interfere with the measurement of insulin resistance, or jeopardize the validity of self-reported data. Presence of these conditions resulted in complete exclusion or partial exams. These conditions included:Current insulin treatment
boolean
C0680251 (UMLS CUI [1,1])
C0679823 (UMLS CUI [1,2])
C2348563 (UMLS CUI [1,3])
C0035647 (UMLS CUI [1,4])
C0205231 (UMLS CUI [1,5])
C0521102 (UMLS CUI [1,6])
C0242485 (UMLS CUI [1,7])
C0021655 (UMLS CUI [1,8])
C0681906 (UMLS CUI [1,9])
C1519941 (UMLS CUI [1,10])
C3846158 (UMLS CUI [1,11])
C0521116 (UMLS CUI [1,12])
C0745343 (UMLS CUI [1,13])
Heart failure
Item
Heart failure
boolean
C0018802 (UMLS CUI [1,1])
Decompensated emphysema or chronic lung disease
Item
Decompensated emphysema or chronic lung disease
boolean
C0231187 (UMLS CUI [1,1])
C0034067 (UMLS CUI [1,2])
C0746102 (UMLS CUI [1,3])
Current shortness of breath or pulmonary obstructive disease
Item
Current shortness of breath or pulmonary obstructive disease
boolean
C0521116 (UMLS CUI [1,1])
C0013404 (UMLS CUI [1,2])
C0600260 (UMLS CUI [1,3])
Crescendo angina
Item
Crescendo angina
boolean
C0002965 (UMLS CUI [1,1])
Cancer, other than skin cancer, for which the person is currently being treated
Item
Cancer, other than skin cancer, for which the person is currently being treated
boolean
C0006826 (UMLS CUI [1,1])
C4723751 (UMLS CUI [1,2])
C0007114 (UMLS CUI [1,3])
C2827774 (UMLS CUI [1,4])
Seizure disorder or epilepsy
Item
Seizure disorder or epilepsy
boolean
C0014544 (UMLS CUI [1,1])
C0036572 (UMLS CUI [1,2])
Kidney dialysis, transplant, or renal failure
Item
Kidney dialysis, transplant, or renal failure
boolean
C0011946 (UMLS CUI [1,1])
C0035078 (UMLS CUI [1,2])
C0022671 (UMLS CUI [1,3])
A serious illness within the last 6 months (e.g., heart attack, stroke, or major surgery)
Item
A serious illness within the last 6 months (e.g., heart attack, stroke, or major surgery)
boolean
C5419420 (UMLS CUI [1,1])
C3828652 (UMLS CUI [1,2])
C0027051 (UMLS CUI [1,3])
C0038454 (UMLS CUI [1,4])
C0679637 (UMLS CUI [1,5])
Treatment with steroids in the past 6 months
Item
Treatment with steroids in the past 6 months
boolean
C0149783 (UMLS CUI [1,1])
C3828652 (UMLS CUI [1,2])
Pregnancy or breast feeding
Item
Pregnancy or breast feeding
boolean
C0032961 (UMLS CUI [1,1])
C0006147 (UMLS CUI [1,2])
Breast cancer treated with surgery or radiation
Item
Breast cancer treated with surgery or radiation
boolean
C0006142 (UMLS CUI [1,1])
C1522449 (UMLS CUI [1,2])
C0543467 (UMLS CUI [1,3])
Obvious mental disability as noted in the screening interview.
Item
Obvious mental disability as noted in the screening interview.
boolean
C0423893 (UMLS CUI [1,1])
C5706969 (UMLS CUI [1,2])
C0021822 (UMLS CUI [1,3])
A subset of IRAS Family Study participants were included in the genotyping study: Hispanics only; without diabetes; with insulin sensitivity obtained by frequently sampled intravenous glucose tolerance test, and providing consent for genetic studies.
Item
A subset of IRAS Family Study participants were included in the genotyping study: Hispanics only; without diabetes; with insulin sensitivity obtained by frequently sampled intravenous glucose tolerance test, and providing consent for genetic studies.
boolean
C0199236 (UMLS CUI [1,1])
C4554048 (UMLS CUI [1,2])
C1515021 (UMLS CUI [1,3])
C1285573 (UMLS CUI [1,4])
C0086409 (UMLS CUI [2,1])
C0686906 (UMLS CUI [2,2])
C0011849 (UMLS CUI [2,3])
C0920563 (UMLS CUI [2,4])
C1277697 (UMLS CUI [2,5])
C0021911 (UMLS CUI [2,6])
C4034855 (UMLS CUI [2,7])
C2827447 (UMLS CUI [2,8])