**Inclusion Criteria*:* 1) Age ≥18 years. 2) Histological confirmation of invasive breast cancer. 3) Confirmation of breast cancer lesion ≥ 1.5 cm in size by any clinical (physical examination measurement) or radiographic criteria (mammogram, ultrasound or MRI) in the ipsilateral breast. Note: Benign breast disease, LCIS or DCIS in the contralateral breast is allowed. Contralateral invasive breast cancer is allowed if disease is of clinically lower stage and the higher stage lesion will be the study lesion for all biopsies and tissue samples. 4) Provide informed written consent. 5) Willing to return to Mayo Clinic in Rochester, MN, Mayo Clinic in Arizona, or Mayo Clinic in Florida for imaging correlative, surgery, and follow-up. 6) Willing to provide blood samples for correlative research purposes. 7) Willing to provide tissue samples for correlative research purposes. 8) ECOG Performance Status ≤ 2. **Exclusion Criteria*:* 1) Disease in axilla only 2) Receiving any investigational agent which would be considered as a treatment for the primary neoplasm. 3) Other active malignancy ≤ 5 years prior to registration. EXCEPTIONS: Non-melanotic skin cancer or carcinoma-in-situ of the cervix. Note: If there is a history or prior malignancy, they must not be receiving any other treatment for their cancer. 4) Patients who are not planning to receive neoadjuvant chemotherapy. 5) Biopsy proven Stage IV disease. 6) Patients who are pregnant or nursing.
Item
**Inclusion Criteria*:* 1) Age ≥18 years. 2) Histological confirmation of invasive breast cancer. 3) Confirmation of breast cancer lesion ≥ 1.5 cm in size by any clinical (physical examination measurement) or radiographic criteria (mammogram, ultrasound or MRI) in the ipsilateral breast. Note: Benign breast disease, LCIS or DCIS in the contralateral breast is allowed. Contralateral invasive breast cancer is allowed if disease is of clinically lower stage and the higher stage lesion will be the study lesion for all biopsies and tissue samples. 4) Provide informed written consent. 5) Willing to return to Mayo Clinic in Rochester, MN, Mayo Clinic in Arizona, or Mayo Clinic in Florida for imaging correlative, surgery, and follow-up. 6) Willing to provide blood samples for correlative research purposes. 7) Willing to provide tissue samples for correlative research purposes. 8) ECOG Performance Status ≤ 2. **Exclusion Criteria*:* 1) Disease in axilla only 2) Receiving any investigational agent which would be considered as a treatment for the primary neoplasm. 3) Other active malignancy ≤ 5 years prior to registration. EXCEPTIONS: Non-melanotic skin cancer or carcinoma-in-situ of the cervix. Note: If there is a history or prior malignancy, they must not be receiving any other treatment for their cancer. 4) Patients who are not planning to receive neoadjuvant chemotherapy. 5) Biopsy proven Stage IV disease. 6) Patients who are pregnant or nursing.
boolean
C1512693 (UMLS CUI [1,1])
C0001779 (UMLS CUI [1,2])
C1512693 (UMLS CUI [2,1])
C0205462 (UMLS CUI [2,2])
C0521091 (UMLS CUI [2,3])
C0853879 (UMLS CUI [2,4])
C1512693 (UMLS CUI [3,1])
C0678222 (UMLS CUI [3,2])
C0449453 (UMLS CUI [3,3])
C0679228 (UMLS CUI [3,4])
C1512693 (UMLS CUI [4,1])
C0441989 (UMLS CUI [4,2])
C0279563 (UMLS CUI [4,3])
C5231168 (UMLS CUI [4,4])
C1512693 (UMLS CUI [5,1])
C0441988 (UMLS CUI [5,2])
C0853879 (UMLS CUI [5,3])
C0205563 (UMLS CUI [5,4])
C0221198 (UMLS CUI [5,5])
C0947630 (UMLS CUI [5,6])
C0005558 (UMLS CUI [5,7])
C0475358 (UMLS CUI [5,8])
C1512693 (UMLS CUI [6,1])
C0021430 (UMLS CUI [6,2])
C1512693 (UMLS CUI [7,1])
C0600109 (UMLS CUI [7,2])
C2347790 (UMLS CUI [7,3])
C0011923 (UMLS CUI [7,4])
C0543467 (UMLS CUI [7,5])
C1522577 (UMLS CUI [7,6])
C1512693 (UMLS CUI [8,1])
C0600109 (UMLS CUI [8,2])
C1292533 (UMLS CUI [8,3])
C0178913 (UMLS CUI [8,4])
C0242481 (UMLS CUI [8,5])
C1512693 (UMLS CUI [9,1])
C1520224 (UMLS CUI [9,2])
C0680251 (UMLS CUI [10,1])
C1515974 (UMLS CUI [10,2])
C0004454 (UMLS CUI [10,3])
C1548966 (UMLS CUI [10,4])
C0680251 (UMLS CUI [11,1])
C0949266 (UMLS CUI [11,2])
C0680251 (UMLS CUI [12,1])
C0205394 (UMLS CUI [12,2])
C0205177 (UMLS CUI [12,3])
C0006826 (UMLS CUI [12,4])
C1948053 (UMLS CUI [12,5])
C0332300 (UMLS CUI [12,6])
C3846158 (UMLS CUI [12,7])
C0851140 (UMLS CUI [12,8])
C0680251 (UMLS CUI [13,1])
C1298908 (UMLS CUI [13,2])
C0162425 (UMLS CUI [13,3])
C5392214 (UMLS CUI [13,4])
C0680251 (UMLS CUI [14,1])
C0441772 (UMLS CUI [14,2])
C0005558 (UMLS CUI [14,3])
C0680251 (UMLS CUI [15,1])
C5443927 (UMLS CUI [15,2])