Elig.phs001095.v1.p1.1
Item
Cases were ascertained according to the following criteria:
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0243161 (UMLS CUI [1,3])
Elig.phs001095.v1.p1.2
Item
Ashkenazi Jewish origin, defined as having all four grandparents born in Northern or Eastern Europe; subjects with known or suspected Sephardic Jewish or non-Jewish ancestry were excluded.
boolean
C2135555 (UMLS CUI [1,1])
C1704788 (UMLS CUI [1,2])
C0444868 (UMLS CUI [1,3])
C0337471 (UMLS CUI [1,4])
C1300001 (UMLS CUI [1,5])
C0028413 (UMLS CUI [1,6])
C0015177 (UMLS CUI [1,7])
C0680251 (UMLS CUI [2,1])
C0750491 (UMLS CUI [2,2])
C0205309 (UMLS CUI [2,3])
C0574825 (UMLS CUI [2,4])
C1298908 (UMLS CUI [2,5])
C0178443 (UMLS CUI [2,6])
C3841890 (UMLS CUI [2,7])
Elig.phs001095.v1.p1.3
Item
T2D defined according to the World Health Organization criteria (fasting glucose >140 mg/dl on two or more occasions or random glucose >200mg/dl).
boolean
C0011860 (UMLS CUI [1,1])
C1704788 (UMLS CUI [1,2])
C0043237 (UMLS CUI [1,3])
C0243161 (UMLS CUI [1,4])
Elig.phs001095.v1.p1.4
Item
To avoid late-onset T1D, patients who became insulin-dependent within 2 years of diagnosis were excluded; anti-GAD or anti-islet cell antibody titers were not routinely measured.
boolean
C0870186 (UMLS CUI [1,1])
C0376415 (UMLS CUI [1,2])
C0011854 (UMLS CUI [1,3])
C0680251 (UMLS CUI [2,1])
C0030705 (UMLS CUI [2,2])
C0011860 (UMLS CUI [2,3])
C1524063 (UMLS CUI [2,4])
C0021641 (UMLS CUI [2,5])
C0332285 (UMLS CUI [2,6])
C0205448 (UMLS CUI [2,7])
C0439234 (UMLS CUI [2,8])
C0011900 (UMLS CUI [2,9])
C1298908 (UMLS CUI [3,1])
C0205547 (UMLS CUI [3,2])
C0242485 (UMLS CUI [3,3])
C1167897 (UMLS CUI [3,4])
C0063900 (UMLS CUI [3,5])
Elig.phs001095.v1.p1.5
Item
T2D cases were selected from two separate DNA collections:
boolean
C1706256 (UMLS CUI [1,1])
C0011860 (UMLS CUI [1,2])
C0242802 (UMLS CUI [1,3])
C0205448 (UMLS CUI [1,4])
C0443299 (UMLS CUI [1,5])
C0012854 (UMLS CUI [1,6])
C0010995 (UMLS CUI [1,7])
Elig.phs001095.v1.p1.6
Item
Genome-wide, affected-sibling-pair linkage study (Permutt et al. Diabetes 2001). Families in which both parents were known to have diabetes were excluded. One affected individual selected from each family and, wherever possible, sibling with youngest age of diagnosis selected.
boolean
C3640076 (UMLS CUI [1,1])
C0522476 (UMLS CUI [1,2])
C0037047 (UMLS CUI [1,3])
C1709450 (UMLS CUI [1,4])
C0796345 (UMLS CUI [1,5])
C0680251 (UMLS CUI [2,1])
C1706086 (UMLS CUI [2,2])
C0030551 (UMLS CUI [2,3])
C0522476 (UMLS CUI [2,4])
C0011849 (UMLS CUI [2,5])
Elig.phs001095.v1.p1.7
Item
Study to determine genetic risk for diabetic complications (Blech et al. PLoS One 2011). Patients ascertained by the Israel Diabetes Research Group between 2002 and 2004 from 15 diabetes clinics throughout Israel. Primary selection criteria: (1) known T1D or T2D for more than 10 years, (2) 4 grandparents being either Ashkenazi or Sephardic-North African Jewish. For this study, only T2D patients with all 4 grandparents of Ashkenazi Jewish origin and age of diagnosis between 35 and 60 were selected. Controls were determined according to the following criteria:
boolean
C0008976 (UMLS CUI [1,1])
C1148554 (UMLS CUI [1,2])
C0314603 (UMLS CUI [1,3])
C0035647 (UMLS CUI [1,4])
C0342257 (UMLS CUI [1,5])
C0242802 (UMLS CUI [2,1])
C0022271 (UMLS CUI [2,2])
C0011849 (UMLS CUI [2,3])
C0242481 (UMLS CUI [2,4])
C0441833 (UMLS CUI [2,5])
C0442592 (UMLS CUI [2,6])
C0205225 (UMLS CUI [3,1])
C0242801 (UMLS CUI [3,2])
C0205309 (UMLS CUI [3,3])
C0011860 (UMLS CUI [3,4])
C0011854 (UMLS CUI [3,5])
C0449238 (UMLS CUI [3,6])
C0444868 (UMLS CUI [3,7])
C0337471 (UMLS CUI [3,8])
C0337704 (UMLS CUI [3,9])
C0574825 (UMLS CUI [3,10])
C0242802 (UMLS CUI [4,1])
C0205171 (UMLS CUI [4,2])
C0030705 (UMLS CUI [4,3])
C0011860 (UMLS CUI [4,4])
C0444868 (UMLS CUI [4,5])
C0337471 (UMLS CUI [4,6])
C0337704 (UMLS CUI [4,7])
C1828181 (UMLS CUI [4,8])
C0009932 (UMLS CUI [5,1])
C1512693 (UMLS CUI [5,2])
C0243161 (UMLS CUI [5,3])
Elig.phs001095.v1.p1.8
Item
Fasting blood glucose <7 mmol/l.
boolean
C0583513 (UMLS CUI [1,1])
Elig.phs001095.v1.p1.9
Item
No personal history of diabetes.
boolean
C1298908 (UMLS CUI [1,1])
C0262926 (UMLS CUI [1,2])
C0011849 (UMLS CUI [1,3])
Elig.phs001095.v1.p1.10
Item
No anti-diabetic medications.
boolean
C1298908 (UMLS CUI [1,1])
C0935929 (UMLS CUI [1,2])
C0013227 (UMLS CUI [1,3])
Elig.phs001095.v1.p1.11
Item
Patients who became insulin-dependent within 2 years of diagnosis were excluded.
boolean
C0680251 (UMLS CUI [1,1])
C0011860 (UMLS CUI [1,2])
C1524063 (UMLS CUI [1,3])
C0021641 (UMLS CUI [1,4])
C0332285 (UMLS CUI [1,5])
C0205448 (UMLS CUI [1,6])
C0439234 (UMLS CUI [1,7])
C0011900 (UMLS CUI [1,8])