Elig.phs001130.v1.p1.1
Item
*Inclusion* Probands: age 50-75; NIDDM by WHO criteria of at least 5 years duration. Probands were divided into two groups based on the presence or absence of CAD and atherosclerosis. CAD+ probands had one of the following: documented myocardial infarction, catheterization proven CAD, ischemic changes on EKG, or ischemia on stress testing. CAD- probands were free of anginal symptoms, had no history of CAD, myocardial infarction, stroke or peripheral large vessel disease, had no ischemic changes on EKG, and no evidence of vascular disease on physical exam (decreased pulses, carotid bruits, etc.). Probands needed to have a spouse and at least two adult offspring willing and able to participate in the study and to be able to give informed consent.
boolean
C1512693 (UMLS CUI [1,1])
C0001779 (UMLS CUI [1,2])
C0011860 (UMLS CUI [1,3])
C0043237 (UMLS CUI [1,4])
C0679228 (UMLS CUI [1,5])
C0449238 (UMLS CUI [1,6])
C0441833 (UMLS CUI [2,1])
C0012634 (UMLS CUI [2,2])
C0150312 (UMLS CUI [2,3])
C0332197 (UMLS CUI [2,4])
C1956346 (UMLS CUI [2,5])
C0004153 (UMLS CUI [2,6])
C1956346 (UMLS CUI [3,1])
C1514241 (UMLS CUI [3,2])
C0027051 (UMLS CUI [3,3])
C0018795 (UMLS CUI [3,4])
C1956346 (UMLS CUI [3,5])
C2826576 (UMLS CUI [3,6])
C0438154 (UMLS CUI [3,7])
C3494508 (UMLS CUI [3,8])
C0022116 (UMLS CUI [3,9])
C1956346 (UMLS CUI [4,1])
C0205160 (UMLS CUI [4,2])
C1298908 (UMLS CUI [4,3])
C0002962 (UMLS CUI [4,4])
C1298908 (UMLS CUI [4,5])
C0262926 (UMLS CUI [4,6])
C1956346 (UMLS CUI [4,7])
C1298908 (UMLS CUI [4,8])
C0027051 (UMLS CUI [4,9])
C0038454 (UMLS CUI [4,10])
C0085096 (UMLS CUI [4,11])
C1298908 (UMLS CUI [4,12])
C2826576 (UMLS CUI [4,13])
C0013798 (UMLS CUI [4,14])
C1518340 (UMLS CUI [4,15])
C0042373 (UMLS CUI [4,16])
C0031809 (UMLS CUI [4,17])
C0470187 (UMLS CUI [5,1])
C0162409 (UMLS CUI [5,2])
C0205448 (UMLS CUI [5,3])
C0001675 (UMLS CUI [5,4])
C0680063 (UMLS CUI [5,5])
C0085732 (UMLS CUI [5,6])
C0600109 (UMLS CUI [5,7])
C1999230 (UMLS CUI [5,8])
C0021430 (UMLS CUI [5,9])
C0679823 (UMLS CUI [5,10])
Elig.phs001130.v1.p1.2
Item
Spouses and Offspring: age 18 - 75, able to give informed consent.
boolean
C0680063 (UMLS CUI [1,1])
C0162409 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0021430 (UMLS CUI [1,4])
C0085732 (UMLS CUI [1,5])
Elig.phs001130.v1.p1.3
Item
*Exclusion* Probands and spouses only had baseline bloods drawn, including for DNA and cell lines. Offspring, who underwent extensive phenotypic testing, were excluded in the following situations: Myocardial infarction, stroke, or cardiac revascularization/angioplasty within 6 months; blood pressure >200/115 mmHg; symptoms or exam evidence of congestive heart failure or known left ventricular ejection fraction <35%; pregnancy; significant medical illness; serum potassium <3.5 or >5.5 mEq/l off medications; serum albumin <2.5 g/dl; serum creatinine >2.0 mg/dl; serum AST or ALT >3x normal; hematocrit <33%.
boolean
C0680251 (UMLS CUI [1,1])
C0030705 (UMLS CUI [1,2])
C0162409 (UMLS CUI [1,3])
C0205171 (UMLS CUI [1,4])
C1442488 (UMLS CUI [1,5])
C1277698 (UMLS CUI [1,6])
C0012854 (UMLS CUI [1,7])
C0682523 (UMLS CUI [1,8])
C0680063 (UMLS CUI [2,1])
C0031437 (UMLS CUI [2,2])
C1516048 (UMLS CUI [2,3])
C0680251 (UMLS CUI [2,4])
C0027051 (UMLS CUI [2,5])
C0038454 (UMLS CUI [2,6])
C0262926 (UMLS CUI [2,7])
C0332185 (UMLS CUI [2,8])
C0162577 (UMLS CUI [2,9])
C0877341 (UMLS CUI [2,10])
C0020538 (UMLS CUI [2,11])
C0031809 (UMLS CUI [2,12])
C0742758 (UMLS CUI [2,13])
C0392756 (UMLS CUI [2,14])
C0428772 (UMLS CUI [2,15])