Elig.phs001197.v1.p1.1
Item
Participants (18-55 years of age) completed a screening visit to ensure that they met criteria for mental and physical health. A physical examination and lab tests were done. The Structured Clinical Inventory for DSM-IV (SCID-I) was used to determine psychiatric diagnoses for the first 500 participants. The MINI International Neuropsychiatric Interview M.I.N.I was used to determine psychiatric diagnoses for the last 50 participants.
boolean
C0001779 (UMLS CUI [1,1])
C0220908 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])
C0243161 (UMLS CUI [1,4])
C1550543 (UMLS CUI [1,5])
C0025353 (UMLS CUI [1,6])
C3874265 (UMLS CUI [1,7])
C0031809 (UMLS CUI [2,1])
C0022885 (UMLS CUI [2,2])
C0004936 (UMLS CUI [3,1])
C0521095 (UMLS CUI [3,2])
C0935589 (UMLS CUI [3,3])
C0220952 (UMLS CUI [3,4])
C0004936 (UMLS CUI [4,1])
C0521095 (UMLS CUI [4,2])
C4505426 (UMLS CUI [4,3])
Elig.phs001197.v1.p1.2
Item
Exclusion Criteria:
boolean
C0680251 (UMLS CUI [1,1])
Elig.phs001197.v1.p1.3
Item
Psychiatric Disease: Current diagnosis of an Axis I disorder (according to DSM-IV criteria), except for the following:
boolean
C0004936 (UMLS CUI [1,1])
C0521116 (UMLS CUI [1,2])
C0270287 (UMLS CUI [1,3])
C0220952 (UMLS CUI [1,4])
C1705847 (UMLS CUI [1,5])
Elig.phs001197.v1.p1.4
Item
Current Stimulant (Meth) Dependence or Abuse (Meth group only)
boolean
C0521116 (UMLS CUI [1,1])
C0304402 (UMLS CUI [1,2])
C0038580 (UMLS CUI [1,3])
C0038586 (UMLS CUI [1,4])
Elig.phs001197.v1.p1.5
Item
Current Marijuana Dependence or Abuse (both groups)
boolean
C0521116 (UMLS CUI [1,1])
C0024808 (UMLS CUI [1,2])
C0038580 (UMLS CUI [1,3])
C0038586 (UMLS CUI [1,4])
Elig.phs001197.v1.p1.6
Item
Current Nicotine Dependence (both groups)
boolean
C0521116 (UMLS CUI [1,1])
C0028043 (UMLS CUI [1,2])
Elig.phs001197.v1.p1.7
Item
Current Mood Disorder due to substance use
boolean
C0521116 (UMLS CUI [1,1])
C0525045 (UMLS CUI [1,2])
C0678226 (UMLS CUI [1,3])
C0038586 (UMLS CUI [1,4])
Elig.phs001197.v1.p1.8
Item
Current Anxiety Disorder due to substance use
boolean
C0521116 (UMLS CUI [1,1])
C0003469 (UMLS CUI [1,2])
C0678226 (UMLS CUI [1,3])
C0038586 (UMLS CUI [1,4])
Elig.phs001197.v1.p1.9
Item
Drug Use History-Meth abusers must:
boolean
C2239127 (UMLS CUI [1,1])
C0338666 (UMLS CUI [1,2])
C0025611 (UMLS CUI [1,3])
Elig.phs001197.v1.p1.10
Item
Meet DSM-IV criteria for current Meth Dependence or Abuse
boolean
C1550543 (UMLS CUI [1,1])
C0220952 (UMLS CUI [1,2])
C0243161 (UMLS CUI [1,3])
C0521116 (UMLS CUI [1,4])
C0025611 (UMLS CUI [1,5])
C0038586 (UMLS CUI [1,6])
C0038580 (UMLS CUI [1,7])
Elig.phs001197.v1.p1.11
Item
Test positive on day of screening for Meth by urine sample Medications and Substances-Evidence of current use of psychotropic medications or substances other than:
boolean
C0011008 (UMLS CUI [1,1])
C0025611 (UMLS CUI [1,2])
C2711519 (UMLS CUI [1,3])
C0013227 (UMLS CUI [2,1])
C0439861 (UMLS CUI [2,2])
C3887511 (UMLS CUI [2,3])
C0521116 (UMLS CUI [2,4])
C1524063 (UMLS CUI [2,5])
C0033978 (UMLS CUI [2,6])
C1705847 (UMLS CUI [2,7])
Elig.phs001197.v1.p1.12
Item
Light use of marijuana (both groups)
boolean
C1881376 (UMLS CUI [1,1])
C1524063 (UMLS CUI [1,2])
C0024808 (UMLS CUI [1,3])
Elig.phs001197.v1.p1.13
Item
Light use of alcohol (both groups)
boolean
C1881376 (UMLS CUI [1,1])
C0001948 (UMLS CUI [1,2])
Elig.phs001197.v1.p1.14
Item
Nicotine Note: "Light use" defined by qualification for abuse but not dependence. Tobacco (cigarette) consumption is matched between groups to equalize possibly confounding effects of nicotine on cerebral blood flow, which may affect hemodynamic changes measured by fMRI.
boolean
C1704788 (UMLS CUI [1,1])
C1881376 (UMLS CUI [1,2])
C1524063 (UMLS CUI [1,3])
C0028040 (UMLS CUI [1,4])
C1704788 (UMLS CUI [2,1])
C1709790 (UMLS CUI [2,2])
C0038586 (UMLS CUI [2,3])
C1298908 (UMLS CUI [2,4])
C1709790 (UMLS CUI [2,5])
C0038580 (UMLS CUI [2,6])
C0543414 (UMLS CUI [3,1])
C0150103 (UMLS CUI [3,2])
C0441833 (UMLS CUI [3,3])
C2828389 (UMLS CUI [3,4])
C4759729 (UMLS CUI [3,5])
Elig.phs001197.v1.p1.15
Item
CNS Disease-Including:
boolean
C0007682 (UMLS CUI [1,1])
Elig.phs001197.v1.p1.16
Item
Structural brain abnormalities (e.g., neoplasms, subarachnoid cysts)
boolean
C0851391 (UMLS CUI [1,1])
Elig.phs001197.v1.p1.17
Item
Cerebrovascular disease
boolean
C0007820 (UMLS CUI [1,1])
Elig.phs001197.v1.p1.18
Item
Infectious disease (e.g., abscess)
boolean
C0009450 (UMLS CUI [1,1])
Elig.phs001197.v1.p1.19
Item
History of other neurological disease, including stroke or head trauma (defined as loss of consciousness >30 min or requiring hospitalization)
boolean
C0262926 (UMLS CUI [1,1])
C0027765 (UMLS CUI [1,2])
C0559159 (UMLS CUI [1,3])
C0018674 (UMLS CUI [1,4])
Elig.phs001197.v1.p1.20
Item
Cardiovascular Disease:
boolean
C0007222 (UMLS CUI [1,1])
Elig.phs001197.v1.p1.21
Item
Advanced coronary artery disease, endocarditis, or other cardia disease likely to result in cerebral embolism
boolean
C0679246 (UMLS CUI [1,1])
C1956346 (UMLS CUI [1,2])
C0014118 (UMLS CUI [1,3])
C0018799 (UMLS CUI [1,4])
C1444708 (UMLS CUI [1,5])
C1274040 (UMLS CUI [1,6])
C0007780 (UMLS CUI [1,7])
Elig.phs001197.v1.p1.22
Item
Any participant that exhibits evidence of left ventricular hypertrophy will be evaluated for a history of hypertension, and will be excluded from participation if positive for hypertension
boolean
C0679646 (UMLS CUI [1,1])
C3887511 (UMLS CUI [1,2])
C0149721 (UMLS CUI [1,3])
C0679830 (UMLS CUI [1,4])
C0262926 (UMLS CUI [1,5])
C0020538 (UMLS CUI [1,6])
C0680251 (UMLS CUI [2,1])
C0020538 (UMLS CUI [2,2])
Elig.phs001197.v1.p1.23
Item
Any participant that reports cardiac symptoms such as chest pain, presyncope and/or syncope with meth use
boolean
C0679646 (UMLS CUI [1,1])
C0741933 (UMLS CUI [1,2])
C0008031 (UMLS CUI [1,3])
C0700200 (UMLS CUI [1,4])
C0039070 (UMLS CUI [1,5])
C1524063 (UMLS CUI [1,6])
C0025611 (UMLS CUI [1,7])
Elig.phs001197.v1.p1.24
Item
Pulmonary Disease:
boolean
C0024115 (UMLS CUI [1,1])
Elig.phs001197.v1.p1.25
Item
Significant obstructive pulmonary disease
boolean
C0750502 (UMLS CUI [1,1])
C0600260 (UMLS CUI [1,2])
Elig.phs001197.v1.p1.26
Item
Self-reported active tuberculosis
boolean
C2700446 (UMLS CUI [1,1])
C0151332 (UMLS CUI [1,2])
Elig.phs001197.v1.p1.27
Item
Systemic Disease:
boolean
C0442893 (UMLS CUI [1,1])
Elig.phs001197.v1.p1.28
Item
Endocrinopathies
boolean
C0014130 (UMLS CUI [1,1])
Elig.phs001197.v1.p1.29
Item
Renal or hepatic failure
boolean
C0035078 (UMLS CUI [1,1])
C0085605 (UMLS CUI [1,2])
Elig.phs001197.v1.p1.30
Item
Autoimmune disease involving the CNS
boolean
C0004364 (UMLS CUI [1,1])
C1314939 (UMLS CUI [1,2])
C3714787 (UMLS CUI [1,3])
Elig.phs001197.v1.p1.31
Item
Pregnancy:
boolean
C0032961 (UMLS CUI [1,1])
Elig.phs001197.v1.p1.32
Item
Pregnancy, possible pregnancy, or failure to indicate the use of reliable birth control precautions. Note: We administered a pregnancy test to each female participant before starting each of the testing days. Participants must agree to use an effective form of birth control throughout the study. The only acceptable methods of birth control are: 1) oral contraceptive; 2) Depo-Provera injection; 3) intrauterine device; 4) diaphragm with contraceptive jelly; 5) condom with contraceptive jelly, foam, or sponge; 6) tubal ligation or hysterectomy; 7) abstinence from heterosexual intercourse.
boolean
C0032961 (UMLS CUI [1,1])
C0425965 (UMLS CUI [1,2])
C0680095 (UMLS CUI [1,3])
C1524063 (UMLS CUI [1,4])
C0700589 (UMLS CUI [1,5])
C0032976 (UMLS CUI [2,1])
C0332152 (UMLS CUI [2,2])
C0011008 (UMLS CUI [2,3])
C0039593 (UMLS CUI [2,4])
C0545082 (UMLS CUI [2,5])
C1879533 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
C0009905 (UMLS CUI [3,3])
C0582269 (UMLS CUI [3,4])
C0021900 (UMLS CUI [3,5])
C0042241 (UMLS CUI [3,6])
C0087145 (UMLS CUI [3,7])
C0009653 (UMLS CUI [3,8])
C0183461 (UMLS CUI [3,9])
C0020699 (UMLS CUI [3,10])
C0520483 (UMLS CUI [3,11])
C0036899 (UMLS CUI [3,12])
Elig.phs001197.v1.p1.33
Item
HIV:
boolean
C0019682 (UMLS CUI [1,1])
Elig.phs001197.v1.p1.34
Item
HIV-seropositive will be excluded because HIV infection and the development of AIDS produce alterations in brain activity that are dependent on the stage of AIDS. Such effects on brain activity would confound the results of this study.
boolean
C0680251 (UMLS CUI [1,1])
C0019699 (UMLS CUI [1,2])
C0001175 (UMLS CUI [1,3])
Elig.phs001197.v1.p1.35
Item
Severe Hepatic Impairment:
boolean
C0948807 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
Elig.phs001197.v1.p1.36
Item
Participants who have severe hepatic impairment, as assessed by blood tests and/or medical history, will be excluded from participation in order to reduce the risk of an adverse effect due to the administration of medication.
boolean
C0680251 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0948807 (UMLS CUI [1,3])
C1516048 (UMLS CUI [1,4])
C0022885 (UMLS CUI [1,5])
C0262926 (UMLS CUI [1,6])
C0392756 (UMLS CUI [1,7])
C0035647 (UMLS CUI [1,8])
C0877248 (UMLS CUI [1,9])
Elig.phs001197.v1.p1.37
Item
Only for MRI Procedures:
boolean
C0024485 (UMLS CUI [1,1])
Elig.phs001197.v1.p1.38
Item
We excluded any participant whose body contains a ferromagnetic implanted device that might produce a safety hazard during fMRI. We followed guidelines found in the manual, Magnetic Resonance: Bioeffects, Safety, and Patient Management, supplemented by the current information published on the International MR Safety Website: http://www.mrisafety.com/safety_info.asp
boolean
C0680251 (UMLS CUI [1,1])
C3693688 (UMLS CUI [1,2])
C2911688 (UMLS CUI [1,3])
C0347984 (UMLS CUI [1,4])
C0376335 (UMLS CUI [1,5])
Elig.phs001197.v1.p1.39
Item
Language:
boolean
C0023008 (UMLS CUI [1,1])
Elig.phs001197.v1.p1.40
Item
Lack of fluency in English. If a participant is not a fluent English speaker, the language barrier would interfere with performance of psychological tests and completing questionnaires used in the study. The consent form, all questionnaires and instructions are given in English.
boolean
C0332268 (UMLS CUI [1,1])
C0564215 (UMLS CUI [1,2])
C0376245 (UMLS CUI [1,3])
C0237167 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0597198 (UMLS CUI [2,3])
C0033905 (UMLS CUI [2,4])
C0034394 (UMLS CUI [2,5])
C0034394 (UMLS CUI [3,1])
C0021430 (UMLS CUI [3,2])
C1442085 (UMLS CUI [3,3])
C0376245 (UMLS CUI [3,4])
Elig.phs001197.v1.p1.41
Item
Neurological:
boolean
C0746866 (UMLS CUI [1,1])
Elig.phs001197.v1.p1.42
Item
Neurological status that is not within normal limits as determined by a physician and as indicated in self-reports.
boolean
C0746866 (UMLS CUI [1,1])
C0205161 (UMLS CUI [1,2])
C0521095 (UMLS CUI [1,3])
C0031831 (UMLS CUI [1,4])
C2700446 (UMLS CUI [1,5])
Elig.phs001197.v1.p1.43
Item
Radiation Exposure: Participated in any other research study involving exposure to ionizing radiation in the past year, relating to study visit date, if the total cumulative exposure from the past research studies and the current research study exceeded the limits described by the FDA in 21 CFR 361.1. Specifically, the total cumulated dose to the whole body, active blood-forming organs, lens of the eye, and gonads must have remained below 5 rems, and the cumulated dose to all other organs must have remained below 15 rems.
boolean
C0015333 (UMLS CUI [1,1])
C0679823 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C0008972 (UMLS CUI [1,4])
C0479513 (UMLS CUI [1,5])
C4086728 (UMLS CUI [1,6])
C2986497 (UMLS CUI [1,7])
C0015333 (UMLS CUI [1,8])
C3846158 (UMLS CUI [1,9])
C0150269 (UMLS CUI [1,10])
C0678257 (UMLS CUI [1,11])
C0041714 (UMLS CUI [1,12])
C2986497 (UMLS CUI [2,1])
C0370231 (UMLS CUI [2,2])
C1328851 (UMLS CUI [2,3])
C0023317 (UMLS CUI [2,4])
C0018067 (UMLS CUI [2,5])
C0439092 (UMLS CUI [2,6])
C3846158 (UMLS CUI [2,7])
C2986497 (UMLS CUI [3,1])
C0205394 (UMLS CUI [3,2])
C0178784 (UMLS CUI [3,3])
C0439092 (UMLS CUI [3,4])
C3846158 (UMLS CUI [3,5])
Elig.phs001197.v1.p1.44
Item
Radiation Exposure: Participated in any other research study involving exposure to ionizing radiation in the past year, relating to study visit date, if the total cumulative exposure from the past research studies and the current research study exceeded the limits described by the FDA in 21 CFR 361.1. Specifically, the total cumulated dose to the whole body, active blood-forming organs, lens of the eye, and gonads must have remained below 5 rems, and the cumulated dose to all other organs must have remained below 15 rems.
boolean
C0015333 (UMLS CUI [1,1])
C0679823 (UMLS CUI [1,2])
C0205394 (UMLS CUI [1,3])
C0008972 (UMLS CUI [1,4])
C0479513 (UMLS CUI [1,5])
C2986497 (UMLS CUI [1,6])
C0015333 (UMLS CUI [1,7])
C3846158 (UMLS CUI [1,8])
C0150269 (UMLS CUI [1,9])
C0678257 (UMLS CUI [1,10])
C0041714 (UMLS CUI [1,11])
C2986497 (UMLS CUI [2,1])
C0370231 (UMLS CUI [2,2])
C1328851 (UMLS CUI [2,3])
C0023317 (UMLS CUI [2,4])
C0439092 (UMLS CUI [2,5])
C3846158 (UMLS CUI [2,6])
C2986497 (UMLS CUI [3,1])
C0205394 (UMLS CUI [3,2])
C0178784 (UMLS CUI [3,3])
C0439092 (UMLS CUI [3,4])
C3846158 (UMLS CUI [3,5])