Elig.phs001229.v1.p1.1
Item
For exome sequenced samples, all patients provided written informed consent for the use of their samples in sequencing as part of the Washington University School of Medicine (WUSM) Lymphoma Banking Program. All patients with adequate excisional biopsy tissue available from 2008-2013 were included. Non-malignant samples were also collected (skin punch biopsies). Pathology review was performed on frozen lymph node samples to confirm the diagnosis and estimate tumor cell content. Frozen sections (tumor and skin) were cut and used for genomic DNA isolation. For cases there were flow sorted, CD19+ and light chain restricted B cells were purified (>98% pure) using a Reflection instrument. For additional capture sequencing, a cohort of FL patients was identified from those evaluated at WUSM/Siteman Cancer Center from 2001-2013. Patients were included if FFPE blocks from an excisional biopsy and clinical information regarding initial treatment and follow-up were available. All FFPE tissue was reviewed to confirm the pathology diagnosis and marked for block punches in confirmed tumor-containing areas.
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C1518371 (UMLS CUI [3,2])
C0870078 (UMLS CUI [3,3])
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C4039816 (UMLS CUI [4,3])
C0024204 (UMLS CUI [4,4])
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C0006826 (UMLS CUI [4,7])
C0007634 (UMLS CUI [4,8])
C0456205 (UMLS CUI [4,9])
C1524063 (UMLS CUI [5,1])
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C0887950 (UMLS CUI [5,4])
C0012854 (UMLS CUI [5,5])
C1698493 (UMLS CUI [6,1])
C4288191 (UMLS CUI [6,2])
C0803951 (UMLS CUI [6,3])
C3846158 (UMLS CUI [6,4])
C1524062 (UMLS CUI [7,1])
C1328887 (UMLS CUI [7,2])
C1269815 (UMLS CUI [7,3])
C0024301 (UMLS CUI [7,4])
C1512693 (UMLS CUI [8,1])
C0470187 (UMLS CUI [8,2])
C4039816 (UMLS CUI [8,3])
C0184921 (UMLS CUI [8,4])
C0205210 (UMLS CUI [8,5])
C1533716 (UMLS CUI [8,6])
C0205265 (UMLS CUI [8,7])
C0087111 (UMLS CUI [8,8])
C1522577 (UMLS CUI [8,9])
C1704362 (UMLS CUI [9,1])
C4039816 (UMLS CUI [9,2])
C0750484 (UMLS CUI [9,3])
C0011900 (UMLS CUI [9,4])
C1708936 (UMLS CUI [9,5])
C0205145 (UMLS CUI [9,6])
C0006826 (UMLS CUI [9,7])