Elig.phs001303.v1.p1.1
Item
*Case-Control Study:* The study was designed as a pair-matched, case-control study, although additional controls were initially identified because of the transient nature of the military population. By use of the computerized Defense Medical Surveillance System database, all available controls were identified for each potential case participant. From the list of possible controls, four individuals who matched each case on age (within 1 year), race (White, Black, other), and date of available serum sample (within 30 days) were chosen at random as the control set. The first man on the list was designated as the primary control. Every attempt was made to enroll this man for 30 days (average number of attempted contacts = 90). The effort included tracing attempts, multiple letters, and telephone calls. If the man could not be traced, was deployed to a combat zone, was deceased, refused to participate, or could not be contacted within a 30-day period, attempts were begun to enroll the next possible control in the set.
boolean
C0007328 (UMLS CUI [1,1])
C0085145 (UMLS CUI [1,2])
C1524062 (UMLS CUI [1,3])
C2986479 (UMLS CUI [1,4])
C0205374 (UMLS CUI [1,5])
C0441833 (UMLS CUI [1,6])
C0026126 (UMLS CUI [1,7])
C3841595 (UMLS CUI [2,1])
C2986479 (UMLS CUI [2,2])
C0600091 (UMLS CUI [2,3])
C1698493 (UMLS CUI [2,4])
C0332149 (UMLS CUI [3,1])
C2986479 (UMLS CUI [3,2])
C1707391 (UMLS CUI [3,3])
C1708943 (UMLS CUI [3,4])
C0001779 (UMLS CUI [3,5])
C0034510 (UMLS CUI [3,6])
C0011008 (UMLS CUI [3,7])
C0200345 (UMLS CUI [3,8])
C0205435 (UMLS CUI [4,1])
C2986479 (UMLS CUI [4,2])
C0745732 (UMLS CUI [4,3])
C0205225 (UMLS CUI [4,4])
C0009932 (UMLS CUI [4,5])
C1516084 (UMLS CUI [5,1])
C1516879 (UMLS CUI [5,2])
C0449238 (UMLS CUI [5,3])
C0439231 (UMLS CUI [5,4])
C0332257 (UMLS CUI [5,5])
C0243095 (UMLS CUI [5,6])
C0439064 (UMLS CUI [5,7])
C0024492 (UMLS CUI [5,8])
C0302186 (UMLS CUI [5,9])
C1272705 (UMLS CUI [6,1])
C1516084 (UMLS CUI [6,2])
C1516879 (UMLS CUI [6,3])
C2135356 (UMLS CUI [6,4])
C1555024 (UMLS CUI [6,5])
C1136454 (UMLS CUI [6,6])
C0439659 (UMLS CUI [6,7])
C1516879 (UMLS CUI [6,8])
C0205436 (UMLS CUI [6,9])
C2986479 (UMLS CUI [6,10])
Elig.phs001303.v1.p1.2
Item
The database linkage identified 961 cases who appeared to meet the study criteria. Further review found that 76 men could not be traced, 27 had died, three were known to be deployed to a combat zone, and two were found ineligible, leaving 853 possible participants. Of these men, 22 were in the process of being contacted when the study closed. Thus, of the 831 men contacted, 754 agreed to participate, resulting in a participation rate of 91 percent. In the instances where the potential case was deceased, the study attempted to obtain proxy information from the man's mother. Thirteen proxy questionnaires were completed by the mothers of the 27 deceased men. Among the controls, 2,579 were evaluated for inclusion. Of these men, 385 men could not be traced, 18 had died, 64 were known to be deployed to a combat zone, and two were found to be ineligible. In addition, 928 could not be contacted within 30 days. Of the remaining 1,182 men, 32 were in the process of being contacted when the study closed. Thus, of the 1,150 men contacted, 928 agreed to participate, resulting in a participation rate of 81 percent. Among the 754 cases and 928 controls, there were 720 matched case-control pairs.
boolean
C0242356 (UMLS CUI [1,1])
C0600091 (UMLS CUI [1,2])
C0868928 (UMLS CUI [1,3])
C1550543 (UMLS CUI [1,4])
C0243161 (UMLS CUI [1,5])
C1698493 (UMLS CUI [1,6])
C1265611 (UMLS CUI [2,1])
C1698493 (UMLS CUI [2,2])
C1299582 (UMLS CUI [2,3])
C0243095 (UMLS CUI [2,4])
C1265611 (UMLS CUI [3,1])
C1698493 (UMLS CUI [3,2])
C1555024 (UMLS CUI [3,3])
C1265611 (UMLS CUI [4,1])
C1698493 (UMLS CUI [4,2])
C2135356 (UMLS CUI [4,3])
C1265611 (UMLS CUI [5,1])
C1698493 (UMLS CUI [5,2])
C5236167 (UMLS CUI [5,3])
C1698493 (UMLS CUI [6,1])
C0679823 (UMLS CUI [6,2])
C1521828 (UMLS CUI [6,3])
C3245505 (UMLS CUI [7,1])
C1698493 (UMLS CUI [7,2])
C1555024 (UMLS CUI [7,3])
C1516084 (UMLS CUI [7,4])
C1301820 (UMLS CUI [7,5])
C0600420 (UMLS CUI [7,6])
C1533716 (UMLS CUI [7,7])
C0026591 (UMLS CUI [7,8])
C1265611 (UMLS CUI [8,1])
C0600420 (UMLS CUI [8,2])
C0034394 (UMLS CUI [8,3])
C1265611 (UMLS CUI [9,1])
C0600091 (UMLS CUI [9,2])
C1550543 (UMLS CUI [9,3])
C0243161 (UMLS CUI [9,4])
C2986479 (UMLS CUI [9,5])
C1265611 (UMLS CUI [10,1])
C2986479 (UMLS CUI [10,2])
C1299582 (UMLS CUI [10,3])
C0243095 (UMLS CUI [10,4])
C1265611 (UMLS CUI [11,1])
C2986479 (UMLS CUI [11,2])
C1555024 (UMLS CUI [11,3])
C1265611 (UMLS CUI [12,1])
C2986479 (UMLS CUI [12,2])
C2135356 (UMLS CUI [12,3])
C1265611 (UMLS CUI [13,1])
C2986479 (UMLS CUI [13,2])
C5236167 (UMLS CUI [13,3])
C0679823 (UMLS CUI [13,4])
C2986479 (UMLS CUI [14,1])
C0679823 (UMLS CUI [14,2])
C1521828 (UMLS CUI [14,3])
C1265611 (UMLS CUI [15,1])
C0024907 (UMLS CUI [15,2])
C1709450 (UMLS CUI [15,3])
Elig.phs001303.v1.p1.3
Item
*Multiple-Case Family Study:* Familial testicular cancer kindred were identified through mailings to the members of health care provider societies who were likely to encounter TGCT patients in the course of their practice, a study-specific website, and various TGCT patient support/family advocacy groups. Criteria for enrollment into the study include at least one of the following: 1) ≥two men in the family had testicular cancer, 2) one family member has bilateral testicular cancer (that is, independent cancers involving both testicles), or 3) one family member with testicular cancer is a member of a set of genetically identical brothers, such as twins or triplets. We have recruited 733 members from 151 multiple-case families, and collected 649 DNA samples for our genetic analyses. Willing families were brought to the NIH Clinical Center for a 2-day, in-person evaluation by our multidisciplinary team. We collected demographic, family history, cancer risk factor and behavioral/psychosocial data, performed TGCT-related imaging studies and collected a variety of biological specimens. Family members who were unable or unwilling to travel to NIH completed study questionnaires and contributed biological specimens in their home communities. We attempted to objectively verify every cancer reported among bloodline family members.
boolean
C0439064 (UMLS CUI [1,1])
C1698493 (UMLS CUI [1,2])
C0199236 (UMLS CUI [1,3])
C0600091 (UMLS CUI [2,1])
C0851352 (UMLS CUI [2,2])
C0855197 (UMLS CUI [2,3])
C0024492 (UMLS CUI [2,4])
C0018724 (UMLS CUI [2,5])
C2349146 (UMLS CUI [2,6])
C0557818 (UMLS CUI [2,7])
C0680786 (UMLS CUI [2,8])
C1550543 (UMLS CUI [3,1])
C1516879 (UMLS CUI [3,2])
C0243161 (UMLS CUI [3,3])
C0205448 (UMLS CUI [3,4])
C0086582 (UMLS CUI [3,5])
C0855197 (UMLS CUI [3,6])
C1550543 (UMLS CUI [4,1])
C1516879 (UMLS CUI [4,2])
C0243161 (UMLS CUI [4,3])
C0205447 (UMLS CUI [4,4])
C0086282 (UMLS CUI [4,5])
C0238767 (UMLS CUI [4,6])
C0855197 (UMLS CUI [4,7])
C1550543 (UMLS CUI [5,1])
C1516879 (UMLS CUI [5,2])
C0243161 (UMLS CUI [5,3])
C0205447 (UMLS CUI [5,4])
C0086282 (UMLS CUI [5,5])
C0855197 (UMLS CUI [5,6])
C1292711 (UMLS CUI [5,7])
C0041427 (UMLS CUI [5,8])
C1265611 (UMLS CUI [6,1])
C0242800 (UMLS CUI [6,2])
C1516698 (UMLS CUI [6,3])
C0012854 (UMLS CUI [6,4])
C0600109 (UMLS CUI [7,1])
C0015576 (UMLS CUI [7,2])
C0008972 (UMLS CUI [7,3])
C1552416 (UMLS CUI [7,4])
C4316356 (UMLS CUI [7,5])
C0220825 (UMLS CUI [7,6])
C1144866 (UMLS CUI [7,7])
C0010995 (UMLS CUI [8,1])
C0011298 (UMLS CUI [8,2])
C0241889 (UMLS CUI [8,3])
C0279005 (UMLS CUI [8,4])
C0004936 (UMLS CUI [8,5])
C0004930 (UMLS CUI [8,6])
C0011923 (UMLS CUI [8,7])
C0200345 (UMLS CUI [8,8])
C0086282 (UMLS CUI [9,1])
C1299582 (UMLS CUI [9,2])
C0558080 (UMLS CUI [9,3])
C0040802 (UMLS CUI [9,4])
C0200345 (UMLS CUI [9,5])
C0034394 (UMLS CUI [9,6])
C4534363 (UMLS CUI [9,7])
C1571702 (UMLS CUI [10,1])
C1711411 (UMLS CUI [10,2])
C0006826 (UMLS CUI [10,3])