Elig.phs001312.v1.p1.1
Item
Inclusion criteria for POAAGG subjects includes age over 35 years and self-identification as Black (African-American, African descent, or African Caribbean). Exclusion criteria include a history of narrow angle, closed angle, neovascular, mixed mechanism, or pseudoexfoliation glaucoma; history of glaucoma secondary to eye surgery or secondary to severe ocular trauma; history of iritis, uveitis, or iridocyclitis; presence of Grave's disease with ocular manifestations, vascular occlusion causing neovascularization of the iris, optic nerve atrophy from other diagnoses, or advanced proliferative diabetic retinopathy.
boolean
C1512693 (UMLS CUI [1,1])
C0001779 (UMLS CUI [1,2])
C0036588 (UMLS CUI [1,3])
C0020792 (UMLS CUI [1,4])
C0085756 (UMLS CUI [1,5])
C0680251 (UMLS CUI [2,1])
C0262926 (UMLS CUI [2,2])
C0154947 (UMLS CUI [2,3])
C0017605 (UMLS CUI [2,4])
C0017609 (UMLS CUI [2,5])
C0686361 (UMLS CUI [2,6])
C4022815 (UMLS CUI [2,7])
C0017601 (UMLS CUI [2,8])
C0149893 (UMLS CUI [2,9])
C0038901 (UMLS CUI [2,10])
C0339594 (UMLS CUI [2,11])
C0022081 (UMLS CUI [2,12])
C0042164 (UMLS CUI [2,13])
C0022073 (UMLS CUI [2,14])
C0018213 (UMLS CUI [2,15])
C0015411 (UMLS CUI [2,16])
C0264995 (UMLS CUI [2,17])
C0271110 (UMLS CUI [2,18])
C0029124 (UMLS CUI [2,19])
C0154830 (UMLS CUI [2,20])
C0205179 (UMLS CUI [2,21])
Elig.phs001312.v1.p1.2
Item
POAG cases were defined as having an open iridocorneal angle and: (1) characteristic glaucomatous optic nerve findings in one or both eyes consisting of at least one of the following: notching, neuroretinal rim thinning, excavation, or a nerve fiber layer defect; (2) characteristic visual field defects on two consecutive reliable visual field tests in at least one eye, which were consistent with the observed optic nerve defects in that eye, as determined by fellowship-trained glaucoma specialists; and (3) all secondary causes of glaucoma excluded. Normal controls were defined as subjects older than 35, without: (1) high myopia (greater than -8.00 diopters); (2) high presbyopia (+8.00 diopters); (3) abnormal visual field; (4) IOP greater than 21 mmHg; (5) neuroretinal rim thinning, excavation, notching or nerve fiber layer defects; (6) optic nerves asymmetry; or (7) a cup-to-disc ratio difference between eyes greater than 0.2.
boolean
C0017612 (UMLS CUI [1,1])
C1698493 (UMLS CUI [1,2])
C1704788 (UMLS CUI [1,3])
C0175566 (UMLS CUI [2,1])
C0229238 (UMLS CUI [2,2])
C0599878 (UMLS CUI [2,3])
C0161398 (UMLS CUI [2,4])
C3494921 (UMLS CUI [2,5])
C5232580 (UMLS CUI [2,6])
C5209222 (UMLS CUI [2,7])
C3846158 (UMLS CUI [2,8])
C3887875 (UMLS CUI [3,1])
C0205448 (UMLS CUI [3,2])
C1707491 (UMLS CUI [3,3])
C0854021 (UMLS CUI [3,4])
C0332290 (UMLS CUI [3,5])
C0161398 (UMLS CUI [3,6])
C0680251 (UMLS CUI [4,1])
C0149893 (UMLS CUI [4,2])
C2705716 (UMLS CUI [5,1])
C0001779 (UMLS CUI [5,2])
C1298908 (UMLS CUI [5,3])
C0271183 (UMLS CUI [5,4])
C0205082 (UMLS CUI [5,5])
C0033075 (UMLS CUI [5,6])
C0854021 (UMLS CUI [5,7])
C0028840 (UMLS CUI [5,8])
C3494921 (UMLS CUI [5,9])
C5209222 (UMLS CUI [5,10])
C5232580 (UMLS CUI [5,11])
C3846158 (UMLS CUI [5,12])
C0029130 (UMLS CUI [5,13])
C0332514 (UMLS CUI [5,14])
C0423471 (UMLS CUI [5,15])