*Selection into GENOA*
Item
*Selection into GENOA*
boolean
C3846158 (UMLS CUI [1,1])
At least two siblings in each sibship needed to have essential hypertension diagnosed prior to age 60 years of age, defined as: 1) average of the last 2 out of 3 systolic BP readings = 140mmHg, or 2) an average of the last 2 out of 3 diastolic BP readings = 90 mmHg, or 3) previous diagnosis of hypertension and antihypertensive medication prescribed by a physician to be taken daily during the last month.
Item
At least two siblings in each sibship needed to have essential hypertension diagnosed prior to age 60 years of age, defined as: 1) average of the last 2 out of 3 systolic BP readings = 140mmHg, or 2) an average of the last 2 out of 3 diastolic BP readings = 90 mmHg, or 3) previous diagnosis of hypertension and antihypertensive medication prescribed by a physician to be taken daily during the last month.
boolean
C0037047 (UMLS CUI [1,1])
C0085580 (UMLS CUI [1,2])
C0011900 (UMLS CUI [1,3])
C0001779 (UMLS CUI [1,4])
C1704788 (UMLS CUI [1,5])
C1510992 (UMLS CUI [1,6])
C0871470 (UMLS CUI [1,7])
C0428883 (UMLS CUI [1,8])
C0332132 (UMLS CUI [1,9])
C0020538 (UMLS CUI [1,10])
C0003364 (UMLS CUI [1,11])
C0278329 (UMLS CUI [1,12])
C0031831 (UMLS CUI [1,13])
C0332173 (UMLS CUI [1,14])
C1512806 (UMLS CUI [1,15])
The definition of essential hypertension excluded those with diagnosis of hypertension = 60 yrs of age, or secondary causes of hypertension including but not limited to prior knowledge of renal parenchymal disease or serum creatinine = 2.5 mg/dL, renal vascular disease, primary aldosteronism, pheochromocytoma, coarctation of aorta, hypertension associated with current use of oral contraceptive agents, prescription or non-prescription drugs, or active alcohol abuse.
Item
The definition of essential hypertension excluded those with diagnosis of hypertension = 60 yrs of age, or secondary causes of hypertension including but not limited to prior knowledge of renal parenchymal disease or serum creatinine = 2.5 mg/dL, renal vascular disease, primary aldosteronism, pheochromocytoma, coarctation of aorta, hypertension associated with current use of oral contraceptive agents, prescription or non-prescription drugs, or active alcohol abuse.
boolean
C0034510 (UMLS CUI [1,1])
C1704788 (UMLS CUI [1,2])
C0085580 (UMLS CUI [1,3])
C2828389 (UMLS CUI [1,4])
C0011900 (UMLS CUI [1,5])
C0020538 (UMLS CUI [1,6])
C0001779 (UMLS CUI [1,7])
C0155616 (UMLS CUI [1,8])
C1841992 (UMLS CUI [1,9])
C0201976 (UMLS CUI [1,10])
C0268790 (UMLS CUI [1,11])
C2874194 (UMLS CUI [1,12])
C0031511 (UMLS CUI [1,13])
C0003492 (UMLS CUI [1,14])
C0745125 (UMLS CUI [1,15])
C0013231 (UMLS CUI [1,16])
C0278329 (UMLS CUI [1,17])
C0085762 (UMLS CUI [1,18])
Exclusion criteria for all participants included secondary hypertension, alcoholism or drug abuse, pregnancy, breast feeding, and type I diabetes mellitus (juvenile onset, insulin dependent) or active malignancy.
Item
Exclusion criteria for all participants included secondary hypertension, alcoholism or drug abuse, pregnancy, breast feeding, and type I diabetes mellitus (juvenile onset, insulin dependent) or active malignancy.
boolean
C0680251 (UMLS CUI [1,1])
C0155616 (UMLS CUI [1,2])
C0013146 (UMLS CUI [1,3])
C0699757 (UMLS CUI [1,4])
C0032961 (UMLS CUI [1,5])
C0006147 (UMLS CUI [1,6])
C0011854 (UMLS CUI [1,7])
C0006826 (UMLS CUI [1,8])
C0679217 (UMLS CUI [1,9])
*Selection into TOPMed*
Item
*Selection into TOPMed*
boolean
C3846158 (UMLS CUI [1,1])
Every participant with an echocardiogram was selected for WGS. We then selected 106 participants who had a computed tomography scan for coronary artery calcification but not an echocardiogram or were a sibling of someone already selected for WGS. Finally, we excluded individuals whom we knew were already being whole genome sequenced through TOPMed or another sequencing effort (GENOA participants who overlap with ARIC or JHS participants). GENOA has phenotypes and omic data for these overlapping participants.
Item
Every participant with an echocardiogram was selected for WGS. We then selected 106 participants who had a computed tomography scan for coronary artery calcification but not an echocardiogram or were a sibling of someone already selected for WGS. Finally, we excluded individuals whom we knew were already being whole genome sequenced through TOPMed or another sequencing effort (GENOA participants who overlap with ARIC or JHS participants). GENOA has phenotypes and omic data for these overlapping participants.
boolean
C0679646 (UMLS CUI [1,1])
C0013516 (UMLS CUI [1,2])
C3640076 (UMLS CUI [1,3])
C0040405 (UMLS CUI [1,4])
C1611184 (UMLS CUI [1,5])
C0037047 (UMLS CUI [1,6])
C2828389 (UMLS CUI [1,7])
C3846158 (UMLS CUI [1,8])
C1948020 (UMLS CUI [1,9])
C0031437 (UMLS CUI [1,10])