The Wave IV DNA collection was intended to address specific study aims of the Add Health Program Project but also to also serve as an archive for future genetic testing when new technology developments could be exploited and genotyping costs reduced. Among eligible respondents at Wave IV, 92% were located and 80% re-interviewed, yielding a Wave IV sample size of 15,701. Of the 15,701 respondents interviewed, 96% consented to DNA collection for purposes of the Program Project aims, and 12,234 (78%) agreed to archive their DNA for future analysis "related to long term health". The extracted DNA is of high quality. The table below displays information (unweighted) about consent for DNA collection and archiving by race/ethnicity. Although there is some variation, primarily regarding archiving of samples, consent was uniformly high across groups, and yielded more than 12,000 samples for genome-wide genotyping with 9,974 passing quality control review.
Item
The Wave IV DNA collection was intended to address specific study aims of the Add Health Program Project but also to also serve as an archive for future genetic testing when new technology developments could be exploited and genotyping costs reduced. Among eligible respondents at Wave IV, 92% were located and 80% re-interviewed, yielding a Wave IV sample size of 15,701. Of the 15,701 respondents interviewed, 96% consented to DNA collection for purposes of the Program Project aims, and 12,234 (78%) agreed to archive their DNA for future analysis "related to long term health". The extracted DNA is of high quality. The table below displays information (unweighted) about consent for DNA collection and archiving by race/ethnicity. Although there is some variation, primarily regarding archiving of samples, consent was uniformly high across groups, and yielded more than 12,000 samples for genome-wide genotyping with 9,974 passing quality control review.
boolean
C0200345 (UMLS CUI [1,1])
C0012854 (UMLS CUI [1,2])
C0947630 (UMLS CUI [1,3])
C1947946 (UMLS CUI [1,4])
C0003738 (UMLS CUI [1,5])
C1320549 (UMLS CUI [1,6])
C0599834 (UMLS CUI [1,7])
C0021430 (UMLS CUI [1,8])
C0441833 (UMLS CUI [1,9])
C0010186 (UMLS CUI [1,10])
C0282122 (UMLS CUI [1,11])
C1548635 (UMLS CUI [1,12])
C0450429 (UMLS CUI [1,13])
C0021822 (UMLS CUI [1,14])
C0242618 (UMLS CUI [1,15])
C1709701 (UMLS CUI [1,16])
C1547867 (UMLS CUI [1,17])
C1830369 (UMLS CUI [1,18])
C0042333 (UMLS CUI [1,19])
C1285573 (UMLS CUI [1,20])
C0034378 (UMLS CUI [1,21])
<th>*Race/ Ethnicity Group*</th> <th>*Number (percentage) consenting to collect DNA*</th> <th>*Number (percentage) of consenting respondents who consent to archive*</th> <th>*Number (percentage) of consenting archive respondents who pass QC for dbGaP file*</th> Hispanic 2393 (96%) 1883 (75%) 1448 (77%) Black 3312 (96%) 2491 (72%) 2081 (84%) White 8372 (97%) 7088 (82%) 5896 (83%) Other, non-Hispanic (Asian, American-Indian, other, including missing race) 1063 (95%) 772 (69%) 550 (71%) TOTAL 15,140 (96%) 12,234 (78%) 9974 (82%)
Item
<th>*Race/ Ethnicity Group*</th> <th>*Number (percentage) consenting to collect DNA*</th> <th>*Number (percentage) of consenting respondents who consent to archive*</th> <th>*Number (percentage) of consenting archive respondents who pass QC for dbGaP file*</th> Hispanic 2393 (96%) 1883 (75%) 1448 (77%) Black 3312 (96%) 2491 (72%) 2081 (84%) White 8372 (97%) 7088 (82%) 5896 (83%) Other, non-Hispanic (Asian, American-Indian, other, including missing race) 1063 (95%) 772 (69%) 550 (71%) TOTAL 15,140 (96%) 12,234 (78%) 9974 (82%)
boolean
C1830369 (UMLS CUI [1,1])
C0441833 (UMLS CUI [1,2])
C1549488 (UMLS CUI [1,3])
C0021430 (UMLS CUI [1,4])
C0012854 (UMLS CUI [1,5])
C0003738 (UMLS CUI [1,6])
C0034378 (UMLS CUI [1,7])
C5420472 (UMLS CUI [1,8])
C0043157 (UMLS CUI [1,9])
C0085756 (UMLS CUI [1,10])
C0086409 (UMLS CUI [1,11])
C1518424 (UMLS CUI [1,12])
C0078988 (UMLS CUI [1,13])
C0002460 (UMLS CUI [1,14])
C0034510 (UMLS CUI [1,15])
The Wave IV sample consists of Wave I participants who agreed to participate in the study at Wave IV. The information below provides background on the Wave I sampling design, Wave I in-home sample that is followed prospectively through time, and the longitudinal design.
Item
The Wave IV sample consists of Wave I participants who agreed to participate in the study at Wave IV. The information below provides background on the Wave I sampling design, Wave I in-home sample that is followed prospectively through time, and the longitudinal design.
boolean
C4554048 (UMLS CUI [1,1])
C0679823 (UMLS CUI [1,2])
C1706907 (UMLS CUI [1,3])
C0815259 (UMLS CUI [1,4])
C0870078 (UMLS CUI [1,5])
C0033522 (UMLS CUI [1,6])
C0023981 (UMLS CUI [1,7])
*In-Home Wave I Samples:* *Main (core) sample* All students who completed the In-School Questionnaire plus those who did not complete a questionnaire but were listed on a school roster were eligible for selection into the core in-home sample. This is a nationally representative sample of adolescents in grades 7 through 12 in the US in the 1994-95 school year. Students in each school were stratified by grade and sex. About 17 students were randomly chosen from each stratum so that a total of approximately 200 adolescents were selected from each of the 80 pairs of schools. A total core sample of 12,105 adolescents was interviewed.
Item
*In-Home Wave I Samples:* *Main (core) sample* All students who completed the In-School Questionnaire plus those who did not complete a questionnaire but were listed on a school roster were eligible for selection into the core in-home sample. This is a nationally representative sample of adolescents in grades 7 through 12 in the US in the 1994-95 school year. Students in each school were stratified by grade and sex. About 17 students were randomly chosen from each stratum so that a total of approximately 200 adolescents were selected from each of the 80 pairs of schools. A total core sample of 12,105 adolescents was interviewed.
boolean
C0079399 (UMLS CUI [1,1])
C0370003 (UMLS CUI [1,2])
C0038492 (UMLS CUI [1,3])
C1556116 (UMLS CUI [1,4])
C0034394 (UMLS CUI [1,5])
*Special oversamples* *Ethnic*: Based on self-reported data from the In-School Questionnaire, four supplementary ethnic-group samples were drawn. Following are the numbers of completed cases in these samples:1,038 blacks from well-educated families (with a parent with a college degree)
Item
*Special oversamples* *Ethnic*: Based on self-reported data from the In-School Questionnaire, four supplementary ethnic-group samples were drawn. Following are the numbers of completed cases in these samples:1,038 blacks from well-educated families (with a parent with a college degree)
boolean
C0205555 (UMLS CUI [1,1])
C0370003 (UMLS CUI [1,2])
C0015031 (UMLS CUI [1,3])
C0681906 (UMLS CUI [1,4])
C0036375 (UMLS CUI [1,5])
C0034394 (UMLS CUI [1,6])
C1556116 (UMLS CUI [1,7])
C0085756 (UMLS CUI [1,8])
C0524327 (UMLS CUI [1,9])
C0015576 (UMLS CUI [1,10])
334 Chinese
Item
334 Chinese
boolean
C0152035 (UMLS CUI [1,1])
450 Cuban
Item
450 Cuban
boolean
C1553379 (UMLS CUI [1,1])
437 Puerto Rican
Item
437 Puerto Rican
boolean
C0034043 (UMLS CUI [1,1])
In addition, the in-home Wave I sample contains more than 1,500 Mexican-Americans and significant numbers of Nicaraguans, Japanese, South Koreans, Filipinos, and Vietnamese. *Saturation*: To enable analysis of social networks, all enrolled students in 16 schools were selected for in-home interviews. These were two large schools (with a total combined enrollment exceeding 3,100) and 14 small schools (with enrollments of fewer than 300). One of the large schools is predominantly white and is located in a mid-sized town. The other is ethnically heterogeneous and is located in a major metropolitan area. The 14 small schools, some public and some private, are located in both rural and urban areas. *Disabled*: A sample of 589 students self-reported on the In-School Questionnaire that they had physical disabilities involving the use of their limbs. Adolescents were considered to be limb disabled if they indicated on the In-School Questionnaire (1) that they had difficulty using their hands, arms, legs, or feet because of a physical condition and (2) that they had used a mechanical device (e.g., wheelchair, cane, brace, or artificial limb) for the past 12 months or more. *Genetic*: The genetic sample consists of pairs of siblings living in the same households. Identical twins, fraternal twins, and half siblings were sampled with certainty. In addition, non-related pairs, such as step-siblings, foster children, and adopted (non-related) siblings, were part of the genetic sample. The majority of full-sibling pairs entered into the sample by chance (disproportionately drawn from the 16 saturation-school samples).
Item
In addition, the in-home Wave I sample contains more than 1,500 Mexican-Americans and significant numbers of Nicaraguans, Japanese, South Koreans, Filipinos, and Vietnamese. *Saturation*: To enable analysis of social networks, all enrolled students in 16 schools were selected for in-home interviews. These were two large schools (with a total combined enrollment exceeding 3,100) and 14 small schools (with enrollments of fewer than 300). One of the large schools is predominantly white and is located in a mid-sized town. The other is ethnically heterogeneous and is located in a major metropolitan area. The 14 small schools, some public and some private, are located in both rural and urban areas. *Disabled*: A sample of 589 students self-reported on the In-School Questionnaire that they had physical disabilities involving the use of their limbs. Adolescents were considered to be limb disabled if they indicated on the In-School Questionnaire (1) that they had difficulty using their hands, arms, legs, or feet because of a physical condition and (2) that they had used a mechanical device (e.g., wheelchair, cane, brace, or artificial limb) for the past 12 months or more. *Genetic*: The genetic sample consists of pairs of siblings living in the same households. Identical twins, fraternal twins, and half siblings were sampled with certainty. In addition, non-related pairs, such as step-siblings, foster children, and adopted (non-related) siblings, were part of the genetic sample. The majority of full-sibling pairs entered into the sample by chance (disproportionately drawn from the 16 saturation-school samples).
boolean
C0370003 (UMLS CUI [1,1])
C3829110 (UMLS CUI [1,2])
C1277464 (UMLS CUI [1,3])
C1556094 (UMLS CUI [1,4])
C1556095 (UMLS CUI [1,5])
C1556093 (UMLS CUI [1,6])
C1561452 (UMLS CUI [1,7])
C0522534 (UMLS CUI [1,8])
C0936012 (UMLS CUI [1,9])
C0150775 (UMLS CUI [1,10])
C0038492 (UMLS CUI [1,11])
C0021822 (UMLS CUI [1,12])
C0036375 (UMLS CUI [1,13])
C0007457 (UMLS CUI [1,14])
C0019409 (UMLS CUI [1,15])
C0015031 (UMLS CUI [1,16])
C0815251 (UMLS CUI [1,17])
C0178876 (UMLS CUI [1,18])
C0178837 (UMLS CUI [1,19])
C1880351 (UMLS CUI [1,20])
C0034394 (UMLS CUI [1,21])
C0036375 (UMLS CUI [1,22])
C0520817 (UMLS CUI [1,23])
C0015385 (UMLS CUI [1,24])
C0018563 (UMLS CUI [1,25])
C1140621 (UMLS CUI [1,26])
C0043143 (UMLS CUI [1,27])
C0006856 (UMLS CUI [1,28])
C0175649 (UMLS CUI [1,29])
C0030761 (UMLS CUI [1,30])
C2348585 (UMLS CUI [1,31])
C0041427 (UMLS CUI [1,32])
C0332218 (UMLS CUI [1,33])
C4086728 (UMLS CUI [1,34])
Longitudinal Design
Item
Longitudinal Design
boolean
C0205127 (UMLS CUI [1,1])
C1707689 (UMLS CUI [1,2])
Beginning with an in-school questionnaire administered to a nationally representative sample of students in grades 7-12, the study followed up with a series of in-home interviews conducted in 1995, 1996, 2001-02, and 2008. The fifth wave of data collection was conducted in 2016-2018. Other sources of data include questionnaires for parents, siblings, fellow students, and school administrators and interviews with romantic partners. Preexisting databases provide information about neighborhoods and communities. The following figure shows the longitudinal design of Add Health including the recent Wave V interview.
Item
Beginning with an in-school questionnaire administered to a nationally representative sample of students in grades 7-12, the study followed up with a series of in-home interviews conducted in 1995, 1996, 2001-02, and 2008. The fifth wave of data collection was conducted in 2016-2018. Other sources of data include questionnaires for parents, siblings, fellow students, and school administrators and interviews with romantic partners. Preexisting databases provide information about neighborhoods and communities. The following figure shows the longitudinal design of Add Health including the recent Wave V interview.
boolean
C0439659 (UMLS CUI [1,1])
C0034394 (UMLS CUI [1,2])
C3846158 (UMLS CUI [1,3])
C2348150 (UMLS CUI [1,4])
C1882932 (UMLS CUI [1,5])
C2030947 (UMLS CUI [1,6])
C0016441 (UMLS CUI [1,7])
C0021822 (UMLS CUI [1,8])
C0010995 (UMLS CUI [1,9])
C0011001 (UMLS CUI [1,10])
C0037047 (UMLS CUI [1,11])
C0030551 (UMLS CUI [1,12])
C0038492 (UMLS CUI [1,13])
C0237456 (UMLS CUI [1,14])
C0683275 (UMLS CUI [1,15])
C0682323 (UMLS CUI [1,16])
C0242356 (UMLS CUI [1,17])
C2347662 (UMLS CUI [1,18])
C0027569 (UMLS CUI [1,19])
C0009462 (UMLS CUI [1,20])
C3658284 (UMLS CUI [1,21])