Elig.phs000658.v1.p1.1
Item
*Sub-study QI:* Study participants were adult twins and their families recruited through the Australian Twin Registry (http://www.twins.org.au) at the Queensland Institute of Medical Research (QIMR). Only unrelated individuals were included in MDD2000AFFY. MDD cases were identified through psychiatric questionnaires, either the shortened Composite International Diagnostic Interview or, for the majority (94%), through the SSAGA-OZ interview instrument (a version of the Semi-Structured Assessment for the Genetics of Alcoholism modified for use in Australia), a comprehensive psychiatric interview designed to assess MDD and other psychiatric disorders according to DSM-IIIR and DSM-IV criteria. Structured interviews were administered by trained telephone interviewers, closely supervised by a clinical psychologist. Briefly, from 1988 to 1990, study participants were mailed an extensive health and lifestyle questionnaire, which included the shortened revised Eysenck personality questionnaire. Sum scores of 12 item responses in each personality domain resulted in quantitative scores for neuroticism. Between 1992-2000, an unselected subset of these participants were interviewed by telephone using the SSAGA-OZ. Over the period 1996-1999 sibling pairs that were either concordant or discordant for extreme neuroticism scores (one sibling in the top or bottom decile, the other sibling in the top or bottom quintile) were recruited to complete the Composite International Diagnostic Interview, which provides DSM-IV lifetime diagnoses of MDD. Finally, some study participants completed the SSAGA-OZ telephone questionnaire in 2003-2007 as part of alcohol and nicotine dependence studies. Screening items for mania were not consistent across interviews and screening items for psychosis were not included; the ability to assess accurately these less common criteria is difficult in large-scale community settings. Therefore, it is possible that a small number of individuals with a primary diagnosis of bipolar disorder or schizophrenia are included in the case group. Some participants may be the same or relatives of those in the OZ-ALC study (dbGaP phs000181.v1.p1).
boolean
C0242800 (UMLS CUI [1,1])
C0041427 (UMLS CUI [1,2])
C0030761 (UMLS CUI [1,3])
C0015576 (UMLS CUI [1,4])
C0034975 (UMLS CUI [1,5])
C1512693 (UMLS CUI [2,1])
C0030705 (UMLS CUI [2,2])
C1546988 (UMLS CUI [2,3])
C1269683 (UMLS CUI [3,1])
C0205396 (UMLS CUI [3,2])
C0846574 (UMLS CUI [3,3])
C0034394 (UMLS CUI [3,4])
C0220952 (UMLS CUI [3,5])
C0679229 (UMLS CUI [3,6])
C0683844 (UMLS CUI [3,7])
C0039457 (UMLS CUI [3,8])
C0021821 (UMLS CUI [3,9])
C0870294 (UMLS CUI [3,10])
C0237412 (UMLS CUI [3,11])
C1948053 (UMLS CUI [4,1])
C0024492 (UMLS CUI [4,2])
C1879301 (UMLS CUI [4,3])
C0392762 (UMLS CUI [4,4])
C2964552 (UMLS CUI [4,5])
C1842981 (UMLS CUI [4,6])
C1948053 (UMLS CUI [5,1])
C1515021 (UMLS CUI [5,2])
C0039457 (UMLS CUI [5,3])
C0021821 (UMLS CUI [5,4])
C0034394 (UMLS CUI [5,5])
C1948053 (UMLS CUI [6,1])
C0037047 (UMLS CUI [6,2])
C4553529 (UMLS CUI [6,3])
C0205403 (UMLS CUI [6,4])
C1842981 (UMLS CUI [6,5])
C2964552 (UMLS CUI [6,6])
C0451085 (UMLS CUI [6,7])
C1269683 (UMLS CUI [6,8])
C0220952 (UMLS CUI [6,9])
C1948053 (UMLS CUI [7,1])
C0037047 (UMLS CUI [7,2])
C1298908 (UMLS CUI [7,3])
C4553529 (UMLS CUI [7,4])
C0205403 (UMLS CUI [7,5])
C1842981 (UMLS CUI [7,6])
C2964552 (UMLS CUI [7,7])
C0451085 (UMLS CUI [7,8])
C1269683 (UMLS CUI [7,9])
C0220952 (UMLS CUI [7,10])
C1948053 (UMLS CUI [8,1])
C0039457 (UMLS CUI [8,2])
C0034394 (UMLS CUI [8,3])
C0038580 (UMLS CUI [8,4])
C0028043 (UMLS CUI [8,5])
C0085762 (UMLS CUI [8,6])
C0220908 (UMLS CUI [9,1])
C0024713 (UMLS CUI [9,2])
C0442809 (UMLS CUI [9,3])
C0021822 (UMLS CUI [9,4])
C1298908 (UMLS CUI [10,1])
C1512693 (UMLS CUI [10,2])
C0220908 (UMLS CUI [10,3])
C0033975 (UMLS CUI [10,4])
C0332149 (UMLS CUI [11,1])
C1512693 (UMLS CUI [11,2])
C0030705 (UMLS CUI [11,3])
C0024713 (UMLS CUI [11,4])
C0033975 (UMLS CUI [11,5])
C1698493 (UMLS CUI [11,6])
Elig.phs000658.v1.p1.2
Item
*Sub-study VU:* These samples do not overlap with those included in a prior MDD GWAS (PMID: 19065144, dbGaP: phs000020.v2.p1) but are drawn from the same parent studies (and include a small number of related individuals). Similar inclusion and exclusion criteria were used to select MDD cases from both the NESDA and NTR studies. Inclusion criteria were a lifetime diagnosis of DSM-IV MDD as determined by the Composite International Diagnostic Interview, age 18-65 years, and self-reported western European ancestry. Those not fluent in Dutch or with a primary diagnosis of schizophrenia.
boolean
C1298908 (UMLS CUI [1,1])
C1948020 (UMLS CUI [1,2])
C0205156 (UMLS CUI [1,3])
C0947630 (UMLS CUI [1,4])
C0807980 (UMLS CUI [2,1])
C0445247 (UMLS CUI [2,2])
C0030551 (UMLS CUI [2,3])
C0947630 (UMLS CUI [2,4])
C1512693 (UMLS CUI [3,1])
C0011900 (UMLS CUI [3,2])
C4071830 (UMLS CUI [3,3])
C1269683 (UMLS CUI [3,4])
C0220952 (UMLS CUI [3,5])
C0001779 (UMLS CUI [3,6])
C2700446 (UMLS CUI [3,7])
C1257905 (UMLS CUI [3,8])
C0680251 (UMLS CUI [4,1])
C1299585 (UMLS CUI [4,2])
C0564215 (UMLS CUI [4,3])
C0376241 (UMLS CUI [4,4])
C0205225 (UMLS CUI [4,5])
C0011900 (UMLS CUI [4,6])
C0036341 (UMLS CUI [4,7])
Elig.phs000658.v1.p1.3
Item
*Sub-study ED:* MDD cases were recruited through in- and out-patient services of psychiatric hospitals in Scotland and were tertiary referrals from primary care. All patients were interviewed by an experienced psychiatrist using the Schedule for Affective Disorders and Schizophrenia-Lifetime, supplemented by hospital case note review and information from informants. Final determination of MDD as the primary DSM-IV diagnosis was made by consensus of two psychiatrists. All cases had a lifetime history of recurrent MDD and IQ > 70. No phenotypic data other than diagnosis and sex are available for this cohort.
boolean
C0242800 (UMLS CUI [1,1])
C1269683 (UMLS CUI [1,2])
C0020021 (UMLS CUI [1,3])
C0036453 (UMLS CUI [1,4])
C0205372 (UMLS CUI [1,5])
C0034927 (UMLS CUI [1,6])
C0033131 (UMLS CUI [1,7])
C0021822 (UMLS CUI [2,1])
C0033872 (UMLS CUI [2,2])
C1524063 (UMLS CUI [2,3])
C0683462 (UMLS CUI [2,4])
C3842891 (UMLS CUI [2,5])
C1546485 (UMLS CUI [3,1])
C1269683 (UMLS CUI [3,2])
C0332137 (UMLS CUI [3,3])
C0220952 (UMLS CUI [3,4])
C0376298 (UMLS CUI [3,5])
C0205448 (UMLS CUI [3,6])
C0033872 (UMLS CUI [3,7])
C4071830 (UMLS CUI [4,1])
C0262926 (UMLS CUI [4,2])
C1269683 (UMLS CUI [4,3])
C1298908 (UMLS CUI [5,1])
C0031437 (UMLS CUI [5,2])
C1511726 (UMLS CUI [5,3])
C0332300 (UMLS CUI [5,4])
C0011900 (UMLS CUI [5,5])
C0079399 (UMLS CUI [5,6])