Inglês

Eligibility Criteria

9 Formulários  
  1. StudyEvent: SEV1
    1. Eligibility Criteria
    2. The subject consent data table includes subject IDs, consent information, and subject aliases.
    3. This pedigree data table contains family relationships in the format of family IDs, subject IDs, father IDs, mother IDs, subjects's sex, and family group ethnicity.
    4. This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs.
    5. Family Subject Phenotypes (WGS) year 1: AD affection status, Braak stage, presence of APOE allele combinations, availability of autopsy material, and general sociodemographic (race and ethnicity) data of participants for whom whole genome sequencing (WGS) data are available.
    6. This sample attributes table includes body site where sample was collected, analyte type, tumor status, and sequencing center.
    7. Connecting Family Subject Phenotypes year 1: participants' family members' AD affection status, Braak stage, APOE allele presence, availability of autopsy material, and general sociodemographic data (race and ethnicity).
    8. Case Control Enriched Phenotypes (WES) year 0: prevalent and incident AD status, AD diagnosis, selection criteria, age (n=2 variables; baseline, onset or last exam), APOE genotype, availability of autopsy data, Braak stage, and general sociodemographic (race and ethnicity) of participants for whom whole exome sequencing (WXS) data are available.
    9. Case Control Enriched Phenotypes (WES) year 1: prevalent and incident AD status, AD diagnosis, selection criteria, age (n=2 variables; baseline, onset or last exam), APOE genotype, availability of autopsy data, Braak stage, and general sociodemographic (race and ethnicity) of participants for whom whole exome sequencing (WXS) data are available.
Inclusion and exclusion criteria
Descrição

Inclusion and exclusion criteria

The samples for the ADSP have been selected from well-characterized cohorts of individuals characterized for AD diagnosis as well as having known AD genetic risk factors. Investigators in the ADSP will obtain from the NIH approved data repositories: (1) quality control checked and 'cleaned' sequence data. 'Quality control checked and cleaned' means a set of routine checks have been performed for sample information, phenotype, and GWAS data to ensure the sequence data are of high quality and are ready for downstream genetic analysis and that likely sources of false-positives have been ruled out, and that samples that are outliers which may skew project-level analyses have been identified; (2) information on the composition of the study cohorts (e.g. case-control, family based, and epidemiology cohorts); (3) descriptions of the study cohorts included in the study; and (4) accompanying phenotypic information such as age at disease onset, self-reported race/ethnicity, gender, diagnostic status, and cognitive measures. The ADSP will determine what additional information, if any, is needed by its members to facilitate the project.
Descrição

The samples for the ADSP have been selected from well-characterized cohorts of individuals characterized for AD diagnosis as well as having known AD genetic risk factors. Investigators in the ADSP will obtain from the NIH approved data repositories: (1) quality control checked and 'cleaned' sequence data. 'Quality control checked and cleaned' means a set of routine checks have been performed for sample information, phenotype, and GWAS data to ensure the sequence data are of high quality and are ready for downstream genetic analysis and that likely sources of false-positives have been ruled out, and that samples that are outliers which may skew project-level analyses have been identified; (2) information on the composition of the study cohorts (e.g. case-control, family based, and epidemiology cohorts); (3) descriptions of the study cohorts included in the study; and (4) accompanying phenotypic information such as age at disease onset, self-reported race/ethnicity, gender, diagnostic status, and cognitive measures. The ADSP will determine what additional information, if any, is needed by its members to facilitate the project.

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0599755
UMLS CUI [1,3]
C0002395
UMLS CUI [2,1]
C1512693
UMLS CUI [2,2]
C0010995
UMLS CUI [2,3]
C0449416
UMLS CUI [2,4]
C3847505
UMLS CUI [2,5]
C0034378
UMLS CUI [2,6]
C0486616
UMLS CUI [3,1]
C1512693
UMLS CUI [3,2]
C0678257
UMLS CUI [3,3]
C0599755
UMLS CUI [4,1]
C1512693
UMLS CUI [4,2]
C0031437
UMLS CUI [4,3]
C0206132
UMLS CUI [4,4]
C0015031
UMLS CUI [4,5]
C0079399
UMLS CUI [4,6]
C1546922
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Similar models

Eligibility Criteria

9 Formulários
  1. StudyEvent: SEV1
    1. Eligibility Criteria
    2. The subject consent data table includes subject IDs, consent information, and subject aliases.
    3. This pedigree data table contains family relationships in the format of family IDs, subject IDs, father IDs, mother IDs, subjects's sex, and family group ethnicity.
    4. This subject sample mapping data table includes a mapping of study subject IDs to sample IDs. Samples are the final preps submitted for genotyping, sequencing, and/or expression data. For example, if one patient (subject ID) gave one sample, and that sample was processed differently to generate 2 sequencing runs, there would be two rows, both using the same subject ID, but having 2 unique sample IDs.
    5. Family Subject Phenotypes (WGS) year 1: AD affection status, Braak stage, presence of APOE allele combinations, availability of autopsy material, and general sociodemographic (race and ethnicity) data of participants for whom whole genome sequencing (WGS) data are available.
    6. This sample attributes table includes body site where sample was collected, analyte type, tumor status, and sequencing center.
    7. Connecting Family Subject Phenotypes year 1: participants' family members' AD affection status, Braak stage, APOE allele presence, availability of autopsy material, and general sociodemographic data (race and ethnicity).
    8. Case Control Enriched Phenotypes (WES) year 0: prevalent and incident AD status, AD diagnosis, selection criteria, age (n=2 variables; baseline, onset or last exam), APOE genotype, availability of autopsy data, Braak stage, and general sociodemographic (race and ethnicity) of participants for whom whole exome sequencing (WXS) data are available.
    9. Case Control Enriched Phenotypes (WES) year 1: prevalent and incident AD status, AD diagnosis, selection criteria, age (n=2 variables; baseline, onset or last exam), APOE genotype, availability of autopsy data, Braak stage, and general sociodemographic (race and ethnicity) of participants for whom whole exome sequencing (WXS) data are available.
Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de dados
Alias
Item Group
Inclusion and exclusion criteria
The samples for the ADSP have been selected from well-characterized cohorts of individuals characterized for AD diagnosis as well as having known AD genetic risk factors. Investigators in the ADSP will obtain from the NIH approved data repositories: (1) quality control checked and 'cleaned' sequence data. 'Quality control checked and cleaned' means a set of routine checks have been performed for sample information, phenotype, and GWAS data to ensure the sequence data are of high quality and are ready for downstream genetic analysis and that likely sources of false-positives have been ruled out, and that samples that are outliers which may skew project-level analyses have been identified; (2) information on the composition of the study cohorts (e.g. case-control, family based, and epidemiology cohorts); (3) descriptions of the study cohorts included in the study; and (4) accompanying phenotypic information such as age at disease onset, self-reported race/ethnicity, gender, diagnostic status, and cognitive measures. The ADSP will determine what additional information, if any, is needed by its members to facilitate the project.
Item
The samples for the ADSP have been selected from well-characterized cohorts of individuals characterized for AD diagnosis as well as having known AD genetic risk factors. Investigators in the ADSP will obtain from the NIH approved data repositories: (1) quality control checked and 'cleaned' sequence data. 'Quality control checked and cleaned' means a set of routine checks have been performed for sample information, phenotype, and GWAS data to ensure the sequence data are of high quality and are ready for downstream genetic analysis and that likely sources of false-positives have been ruled out, and that samples that are outliers which may skew project-level analyses have been identified; (2) information on the composition of the study cohorts (e.g. case-control, family based, and epidemiology cohorts); (3) descriptions of the study cohorts included in the study; and (4) accompanying phenotypic information such as age at disease onset, self-reported race/ethnicity, gender, diagnostic status, and cognitive measures. The ADSP will determine what additional information, if any, is needed by its members to facilitate the project.
boolean
C1512693 (UMLS CUI [1,1])
C0599755 (UMLS CUI [1,2])
C0002395 (UMLS CUI [1,3])
C1512693 (UMLS CUI [2,1])
C0010995 (UMLS CUI [2,2])
C0449416 (UMLS CUI [2,3])
C3847505 (UMLS CUI [2,4])
C0034378 (UMLS CUI [2,5])
C0486616 (UMLS CUI [2,6])
C1512693 (UMLS CUI [3,1])
C0678257 (UMLS CUI [3,2])
C0599755 (UMLS CUI [3,3])
C1512693 (UMLS CUI [4,1])
C0031437 (UMLS CUI [4,2])
C0206132 (UMLS CUI [4,3])
C0015031 (UMLS CUI [4,4])
C0079399 (UMLS CUI [4,5])
C1546922 (UMLS CUI [4,6])
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