Inclusion criteria for Cases: Cases were defined as those subjects ≥18 years of age at the time of an incident of drug-induced LQTS and/or TdP who had one of the following:
Item
Inclusion criteria for Cases: Cases were defined as those subjects ≥18 years of age at the time of an incident of drug-induced LQTS and/or TdP who had one of the following:
boolean
C1512693 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0023976 (UMLS CUI [1,4])
C0458082 (UMLS CUI [1,5])
C0040479 (UMLS CUI [1,6])
An uncorrected QT interval ≥600 msec while on drug that decreased to <480 msec following withdrawal of drug;
Item
An uncorrected QT interval ≥600 msec while on drug that decreased to <480 msec following withdrawal of drug;
boolean
C0242510 (UMLS CUI [1,1])
C0151878 (UMLS CUI [1,2])
C1287082 (UMLS CUI [2,1])
C1395815 (UMLS CUI [2,2])
A change in uncorrected QT interval of at least 100 msec (either from the pre-exposure to the during-exposure ECG or from the during-exposure to the post-exposure ECG) with an uncorrected QT interval >480 msec while on drug; or
Item
A change in uncorrected QT interval of at least 100 msec (either from the pre-exposure to the during-exposure ECG or from the during-exposure to the post-exposure ECG) with an uncorrected QT interval >480 msec while on drug; or
boolean
C1287082 (UMLS CUI [1,1])
C0443172 (UMLS CUI [1,2])
C0332152 (UMLS CUI [1,3])
C0347984 (UMLS CUI [1,4])
C0457083 (UMLS CUI [1,5])
C1287082 (UMLS CUI [2,1])
C0443172 (UMLS CUI [2,2])
C0347984 (UMLS CUI [2,3])
C0687676 (UMLS CUI [2,4])
C0457083 (UMLS CUI [2,5])
An episode of ECG-documented TdP with a subsequent ECG with no evidence of TdP following withdrawal of drug.
Item
An episode of ECG-documented TdP with a subsequent ECG with no evidence of TdP following withdrawal of drug.
boolean
C1623258 (UMLS CUI [1,1])
C0040479 (UMLS CUI [1,2])
C2349954 (UMLS CUI [2,1])
C0332125 (UMLS CUI [2,2])
C0040479 (UMLS CUI [2,3])
Exclusion criteria for Cases:
Item
Exclusion criteria for Cases:
boolean
C0680251 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
Potassium level ≤3 mmol at onset of event (1 mEq = 1 mmol);
Item
Potassium level ≤3 mmol at onset of event (1 mEq = 1 mmol);
boolean
C0302353 (UMLS CUI [1,1])
C0332162 (UMLS CUI [1,2])
C0441471 (UMLS CUI [1,3])
Subarachnoid hemorrhage at onset of event;
Item
Subarachnoid hemorrhage at onset of event;
boolean
C0038525 (UMLS CUI [1,1])
C0332162 (UMLS CUI [1,2])
C0441471 (UMLS CUI [1,3])
Cardiac bypass <24 hours before onset of event;
Item
Cardiac bypass <24 hours before onset of event;
boolean
C0010055 (UMLS CUI [1,1])
C4035156 (UMLS CUI [1,2])
C0332162 (UMLS CUI [1,3])
C0441471 (UMLS CUI [1,4])
Hospital admission diagnosis of hypothermia at time of event;
Item
Hospital admission diagnosis of hypothermia at time of event;
boolean
C0184666 (UMLS CUI [1,1])
C0020672 (UMLS CUI [1,2])
C0332162 (UMLS CUI [1,3])
C0441471 (UMLS CUI [1,4])
Diagnosed with congenital LQTS prior to onset of event;
Item
Diagnosed with congenital LQTS prior to onset of event;
boolean
C1141890 (UMLS CUI [1,1])
C0332152 (UMLS CUI [1,2])
C0332162 (UMLS CUI [1,3])
C0441471 (UMLS CUI [1,4])
Currently leukopenic (WBC<1000 cells/mL);
Item
Currently leukopenic (WBC<1000 cells/mL);
boolean
C0521116 (UMLS CUI [1,1])
C0023530 (UMLS CUI [1,2])
Has had a non-autologous bone marrow transplant at anytime in the past.
Item
Has had a non-autologous bone marrow transplant at anytime in the past.
boolean
C0005961 (UMLS CUI [1,1])
C1444637 (UMLS CUI [1,2])
Inclusion criteria for Controls:
Item
Inclusion criteria for Controls:
boolean
C1512693 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
18 years of age or older;
Item
18 years of age or older;
boolean
C0001779 (UMLS CUI [1,1])
New start on QT-prolonging antiarrhythmic drug(s);
Item
New start on QT-prolonging antiarrhythmic drug(s);
boolean
C0205314 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])
C0003195 (UMLS CUI [1,3])
C0151878 (UMLS CUI [1,4])
Has not received a blood transfusion in the past 4 months.
Item
Has not received a blood transfusion in the past 4 months.
boolean
C1879316 (UMLS CUI [1,1])
C3845783 (UMLS CUI [1,2])