Inglês

Eligibility Criteria

4 Formulários  
  1. StudyEvent: SEV1
    1. Eligibility Criteria
    2. Subject ID, subject source, subject source ID, and consent groups of participants involved in the " National Heart Lung and Blood Institute (NHLBI) GO-ESP: Heart Cohorts Component of the Exome Sequencing Project (JHS) " project.
    3. Sample ID, subject ID, and using of samples obtained from participants involved in the " National Heart Lung and Blood Institute (NHLBI) GO-ESP: Heart Cohorts Component of the Exome Sequencing Project (JHS) " project.
    4. Sociodemographic data including subject ID, sex, race, study site, study cohort, and age, family history of stroke, systolic and diastolic blood pressure, anthropometric data including BMI, body weight, body height, and waist in centimeters, laboratory measurement of blood including eosinophils, basophils, platelet count, red blood count, neutrophils, monocytes, lymphocytes, hematocrit, hemoglobin, Factor VIII, fasting glucose, fasting insulin, ICAM1 level, IL6 level, cystatin C, Digoxin, total cholesterol, triglycerides, HDL, LDL, C-reactive protein, Factor VII level, and Fibrinogen, uric acid, urinary albumin, and urinary creatinine, EKG including HR, PR, QRS, QT, and RR interval measurement, status of myocardial infraction, angioplasty, atrial fibrillation, atrioventricular block, hypertension, left ventricular hypertrophy, gout, and type 2 diabetes, coronary artery calcium Agatston and Framingham Risk Score, intimal-medial thickness, Wolf-Parkinson-White syndrome, treatment with medications, and smoking status of participants involved in the " National Heart Lung and Blood Institute (NHLBI) GO-ESP: Heart Cohorts Component of the Exome Sequencing Project (JHS) " project.
Inclusion and exclusion criteria
Descrição

Inclusion and exclusion criteria

The following are the inclusion/exclusion criteria across the HeartGO consortia phenotype groups; each HeartGO cohort was represented in one or more of these phenotype groups.
Descrição

The following are the inclusion/exclusion criteria across the HeartGO consortia phenotype groups; each HeartGO cohort was represented in one or more of these phenotype groups.

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C1512693
*Early-Onset MI (EOMI):* Within each of two ethnic groups (whites and blacks), selection of 200 cases with early-onset myocardial infarction (MI) and 200 participants with absence of MI despite extreme Framingham Risk Score (FRS). *Inclusion* of individuals with consent and DNA available; for cases, the participant data includes study adjudication of reported MI and onset prior to age 45y (men) or 55y (women); for comparison (non-MI) participants, there must be data to calculate the Framingham Risk Score (FRS; age, sex, total cholesterol, HDL cholesterol, smoking status, systolic blood pressure, blood pressure medications), with age greater than 50y (men) or 60y (women). *Exclusion* of participants with prevalent or incident CVD; cases with self-reported MI but without adjudication of clinical data.
Descrição

*Early-Onset MI (EOMI):* Within each of two ethnic groups (whites and blacks), selection of 200 cases with early-onset myocardial infarction (MI) and 200 participants with absence of MI despite extreme Framingham Risk Score (FRS). *Inclusion* of individuals with consent and DNA available; for cases, the participant data includes study adjudication of reported MI and onset prior to age 45y (men) or 55y (women); for comparison (non-MI) participants, there must be data to calculate the Framingham Risk Score (FRS; age, sex, total cholesterol, HDL cholesterol, smoking status, systolic blood pressure, blood pressure medications), with age greater than 50y (men) or 60y (women). *Exclusion* of participants with prevalent or incident CVD; cases with self-reported MI but without adjudication of clinical data.

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C1275835
UMLS CUI [1,2]
C1279919
UMLS CUI [1,3]
C0085756
UMLS CUI [2,1]
C1275835
UMLS CUI [2,2]
C1279919
UMLS CUI [2,3]
C0043157
UMLS CUI [3,1]
C0085756
UMLS CUI [3,2]
C1298908
UMLS CUI [3,3]
C1275835
UMLS CUI [3,4]
C3176199
UMLS CUI [3,5]
C0684030
UMLS CUI [4,1]
C0043157
UMLS CUI [4,2]
C1298908
UMLS CUI [4,3]
C1275835
UMLS CUI [4,4]
C0684030
UMLS CUI [5,1]
C1512693
UMLS CUI [5,2]
C1698493
UMLS CUI [5,3]
C0021430
UMLS CUI [5,4]
C0470187
UMLS CUI [5,5]
C0444245
UMLS CUI [5,6]
C0011900
UMLS CUI [5,7]
C0027051
UMLS CUI [5,8]
C0001779
UMLS CUI [6,1]
C1512693
UMLS CUI [6,2]
C0009932
UMLS CUI [6,3]
C0021430
UMLS CUI [6,4]
C0470187
UMLS CUI [6,5]
C0444245
UMLS CUI [6,6]
C0470187
UMLS CUI [6,7]
C1511726
UMLS CUI [6,8]
C1441506
UMLS CUI [6,9]
C3176199
UMLS CUI [6,10]
C0001779
UMLS CUI [7,1]
C0680251
UMLS CUI [7,2]
C0007222
UMLS CUI [8,1]
C0680251
UMLS CUI [8,2]
C0681906
UMLS CUI [8,3]
C0027051
UMLS CUI [8,4]
C0332288
UMLS CUI [8,5]
C0011900
*LDL Cholesterol (LDL):* Within each of two ethnic groups (whites and blacks), selection of 100 participants with extremely low LDL and 100 participants with extremely high LDL, after adjustment for age, sex, lipid medication status. *Inclusion* requires consent and available DNA, and presence of the following variables: race, sex, LDL measurement (baseline and any additional), age at LDL measurement, lipid-lowering medication status. *Exclusion*: not being sequenced for other phenotypes.
Descrição

*LDL Cholesterol (LDL):* Within each of two ethnic groups (whites and blacks), selection of 100 participants with extremely low LDL and 100 participants with extremely high LDL, after adjustment for age, sex, lipid medication status. *Inclusion* requires consent and available DNA, and presence of the following variables: race, sex, LDL measurement (baseline and any additional), age at LDL measurement, lipid-lowering medication status. *Exclusion*: not being sequenced for other phenotypes.

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0085756
UMLS CUI [1,2]
C0853085
UMLS CUI [1,3]
C0456081
UMLS CUI [1,4]
C0001779
UMLS CUI [1,5]
C0079399
UMLS CUI [1,6]
C0585943
UMLS CUI [2,1]
C0043157
UMLS CUI [2,2]
C0853085
UMLS CUI [2,3]
C0456081
UMLS CUI [2,4]
C0001779
UMLS CUI [2,5]
C0079399
UMLS CUI [2,6]
C0585943
UMLS CUI [3,1]
C0085756
UMLS CUI [3,2]
C4747855
UMLS CUI [3,3]
C0456081
UMLS CUI [3,4]
C0001779
UMLS CUI [3,5]
C0079399
UMLS CUI [3,6]
C0585943
UMLS CUI [4,1]
C0043157
UMLS CUI [4,2]
C4747855
UMLS CUI [4,3]
C0456081
UMLS CUI [4,4]
C0001779
UMLS CUI [4,5]
C0079399
UMLS CUI [4,6]
C0585943
UMLS CUI [5,1]
C1512693
UMLS CUI [5,2]
C0021430
UMLS CUI [5,3]
C0585943
UMLS CUI [5,4]
C1533716
UMLS CUI [5,5]
C0079399
UMLS CUI [5,6]
C0001779
UMLS CUI [5,7]
C0428474
UMLS CUI [6,1]
C0680251
UMLS CUI [6,2]
C1298908
UMLS CUI [6,3]
C1328887
*Blood Pressure (BP):* Within each of two ethnic groups (whites and blacks), selection of 200 participants with extremely low residual systolic and diastolic blood pressure and 200 participants with extremely high residual systolic and diastolic blood pressure, after adjustment for age, sex, medication status and BMI. *Inclusion* requires consent and available DNA, and presence of the following variables: race, sex, systolic blood pressure (SBP), diastolic blood pressure (DBP), age, hypertension medication status and BMI. *Exclusion* of participants (or data) with age > 69 yr, prevalent MI, heart failure or BMI > 4SD at any exam but only for that exam (for those participants with multiple measurements); for selection of extreme low BP individuals, exclude those individuals who are on antihypertensive treatment or who are unknown to be on antihypertensive treatment.
Descrição

*Blood Pressure (BP):* Within each of two ethnic groups (whites and blacks), selection of 200 participants with extremely low residual systolic and diastolic blood pressure and 200 participants with extremely high residual systolic and diastolic blood pressure, after adjustment for age, sex, medication status and BMI. *Inclusion* requires consent and available DNA, and presence of the following variables: race, sex, systolic blood pressure (SBP), diastolic blood pressure (DBP), age, hypertension medication status and BMI. *Exclusion* of participants (or data) with age > 69 yr, prevalent MI, heart failure or BMI > 4SD at any exam but only for that exam (for those participants with multiple measurements); for selection of extreme low BP individuals, exclude those individuals who are on antihypertensive treatment or who are unknown to be on antihypertensive treatment.

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0085756
UMLS CUI [1,2]
C0205251
UMLS CUI [1,3]
C2704328
UMLS CUI [1,4]
C0456081
UMLS CUI [1,5]
C0001779
UMLS CUI [1,6]
C0079399
UMLS CUI [1,7]
C0585941
UMLS CUI [1,8]
C1305855
UMLS CUI [2,1]
C0043157
UMLS CUI [2,2]
C0205251
UMLS CUI [2,3]
C0456081
UMLS CUI [2,4]
C0001779
UMLS CUI [2,5]
C0079399
UMLS CUI [2,6]
C0585941
UMLS CUI [2,7]
C1305855
UMLS CUI [3,1]
C0085756
UMLS CUI [3,2]
C2704328
UMLS CUI [3,3]
C0456081
UMLS CUI [3,4]
C0001779
UMLS CUI [3,5]
C0079399
UMLS CUI [3,6]
C0585941
UMLS CUI [3,7]
C1305855
UMLS CUI [4,1]
C0043157
UMLS CUI [4,2]
C0205250
UMLS CUI [4,3]
C2704328
UMLS CUI [4,4]
C0456081
UMLS CUI [4,5]
C0001779
UMLS CUI [4,6]
C0079399
UMLS CUI [4,7]
C0585941
UMLS CUI [4,8]
C1305855
UMLS CUI [5,1]
C1512693
UMLS CUI [5,2]
C0021430
UMLS CUI [5,3]
C0012854
UMLS CUI [5,4]
C1533716
UMLS CUI [5,5]
C0034510
UMLS CUI [5,6]
C0001779
UMLS CUI [5,7]
C0428883
UMLS CUI [5,8]
C0871470
UMLS CUI [5,9]
C0585941
UMLS CUI [5,10]
C1305855
UMLS CUI [6,1]
C0680251
UMLS CUI [6,2]
C0001779
UMLS CUI [6,3]
C1298908
UMLS CUI [6,4]
C1328887
UMLS CUI [6,5]
C0027051
UMLS CUI [6,6]
C0018801
UMLS CUI [6,7]
C1305855
UMLS CUI [6,8]
C0585941
*Ischemic Stroke (STROKE):* Within each of two ethnic groups (whites and blacks), selection of 250 participants with early onset (less than 65y) or positive family history of ischemic stroke. These cases will be compared with the deeply phenotyped reference sample. *Inclusion* requires consent and available DNA, and available documentation that the stroke is ischemic and has been adjudicated with characteristics of likely etiology (subtyping). Required variables include race, sex, family history of stroke, and age at stroke. Only participants with a positive family history of stroke and/or diagnosed prior to 65 y will be included. Stroke subtypes included for study include small vessel occlusion/lacunar and large artery atherosclerosis/atherosclerotic (more specifically, non-lacunar and non-cardioembolic). *Exclusion* of participants includes those with absence of subtyping (based on TOAST, SHEP or equivalent criteria). Participants will be excluded if unknown or undefined stroke subtype; cardioembolic stroke subtype is also excluded.
Descrição

*Ischemic Stroke (STROKE):* Within each of two ethnic groups (whites and blacks), selection of 250 participants with early onset (less than 65y) or positive family history of ischemic stroke. These cases will be compared with the deeply phenotyped reference sample. *Inclusion* requires consent and available DNA, and available documentation that the stroke is ischemic and has been adjudicated with characteristics of likely etiology (subtyping). Required variables include race, sex, family history of stroke, and age at stroke. Only participants with a positive family history of stroke and/or diagnosed prior to 65 y will be included. Stroke subtypes included for study include small vessel occlusion/lacunar and large artery atherosclerosis/atherosclerotic (more specifically, non-lacunar and non-cardioembolic). *Exclusion* of participants includes those with absence of subtyping (based on TOAST, SHEP or equivalent criteria). Participants will be excluded if unknown or undefined stroke subtype; cardioembolic stroke subtype is also excluded.

Tipo de dados

boolean

Alias
UMLS CUI [1,1]
C0085756
UMLS CUI [1,2]
C0814120
UMLS CUI [1,3]
C0948008
UMLS CUI [1,4]
C1261367
UMLS CUI [2,1]
C0043157
UMLS CUI [2,2]
C0814120
UMLS CUI [2,3]
C0948008
UMLS CUI [2,4]
C1261367
UMLS CUI [3,1]
C1512693
UMLS CUI [3,2]
C0021430
UMLS CUI [3,3]
C0012854
UMLS CUI [3,4]
C1533716
UMLS CUI [3,5]
C0948008
UMLS CUI [3,6]
C1261367
UMLS CUI [3,7]
C0001779
UMLS CUI [3,8]
C0079399
UMLS CUI [3,9]
C4533393
UMLS CUI [4,1]
C0680251
UMLS CUI [4,2]
C1298908
UMLS CUI [4,3]
C1328887
UMLS CUI [4,4]
C4533393
UMLS CUI [4,5]
C0205427
UMLS CUI [4,6]
C0439673
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Similar models

Eligibility Criteria

4 Formulários
  1. StudyEvent: SEV1
    1. Eligibility Criteria
    2. Subject ID, subject source, subject source ID, and consent groups of participants involved in the " National Heart Lung and Blood Institute (NHLBI) GO-ESP: Heart Cohorts Component of the Exome Sequencing Project (JHS) " project.
    3. Sample ID, subject ID, and using of samples obtained from participants involved in the " National Heart Lung and Blood Institute (NHLBI) GO-ESP: Heart Cohorts Component of the Exome Sequencing Project (JHS) " project.
    4. Sociodemographic data including subject ID, sex, race, study site, study cohort, and age, family history of stroke, systolic and diastolic blood pressure, anthropometric data including BMI, body weight, body height, and waist in centimeters, laboratory measurement of blood including eosinophils, basophils, platelet count, red blood count, neutrophils, monocytes, lymphocytes, hematocrit, hemoglobin, Factor VIII, fasting glucose, fasting insulin, ICAM1 level, IL6 level, cystatin C, Digoxin, total cholesterol, triglycerides, HDL, LDL, C-reactive protein, Factor VII level, and Fibrinogen, uric acid, urinary albumin, and urinary creatinine, EKG including HR, PR, QRS, QT, and RR interval measurement, status of myocardial infraction, angioplasty, atrial fibrillation, atrioventricular block, hypertension, left ventricular hypertrophy, gout, and type 2 diabetes, coronary artery calcium Agatston and Framingham Risk Score, intimal-medial thickness, Wolf-Parkinson-White syndrome, treatment with medications, and smoking status of participants involved in the " National Heart Lung and Blood Institute (NHLBI) GO-ESP: Heart Cohorts Component of the Exome Sequencing Project (JHS) " project.
Name
Tipo
Description | Question | Decode (Coded Value)
Tipo de dados
Alias
Item Group
Inclusion and exclusion criteria
The following are the inclusion/exclusion criteria across the HeartGO consortia phenotype groups; each HeartGO cohort was represented in one or more of these phenotype groups.
Item
The following are the inclusion/exclusion criteria across the HeartGO consortia phenotype groups; each HeartGO cohort was represented in one or more of these phenotype groups.
boolean
C0680251 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
*Early-Onset MI (EOMI):* Within each of two ethnic groups (whites and blacks), selection of 200 cases with early-onset myocardial infarction (MI) and 200 participants with absence of MI despite extreme Framingham Risk Score (FRS). *Inclusion* of individuals with consent and DNA available; for cases, the participant data includes study adjudication of reported MI and onset prior to age 45y (men) or 55y (women); for comparison (non-MI) participants, there must be data to calculate the Framingham Risk Score (FRS; age, sex, total cholesterol, HDL cholesterol, smoking status, systolic blood pressure, blood pressure medications), with age greater than 50y (men) or 60y (women). *Exclusion* of participants with prevalent or incident CVD; cases with self-reported MI but without adjudication of clinical data.
Item
*Early-Onset MI (EOMI):* Within each of two ethnic groups (whites and blacks), selection of 200 cases with early-onset myocardial infarction (MI) and 200 participants with absence of MI despite extreme Framingham Risk Score (FRS). *Inclusion* of individuals with consent and DNA available; for cases, the participant data includes study adjudication of reported MI and onset prior to age 45y (men) or 55y (women); for comparison (non-MI) participants, there must be data to calculate the Framingham Risk Score (FRS; age, sex, total cholesterol, HDL cholesterol, smoking status, systolic blood pressure, blood pressure medications), with age greater than 50y (men) or 60y (women). *Exclusion* of participants with prevalent or incident CVD; cases with self-reported MI but without adjudication of clinical data.
boolean
C1275835 (UMLS CUI [1,1])
C1279919 (UMLS CUI [1,2])
C0085756 (UMLS CUI [1,3])
C1275835 (UMLS CUI [2,1])
C1279919 (UMLS CUI [2,2])
C0043157 (UMLS CUI [2,3])
C0085756 (UMLS CUI [3,1])
C1298908 (UMLS CUI [3,2])
C1275835 (UMLS CUI [3,3])
C3176199 (UMLS CUI [3,4])
C0684030 (UMLS CUI [3,5])
C0043157 (UMLS CUI [4,1])
C1298908 (UMLS CUI [4,2])
C1275835 (UMLS CUI [4,3])
C0684030 (UMLS CUI [4,4])
C1512693 (UMLS CUI [5,1])
C1698493 (UMLS CUI [5,2])
C0021430 (UMLS CUI [5,3])
C0470187 (UMLS CUI [5,4])
C0444245 (UMLS CUI [5,5])
C0011900 (UMLS CUI [5,6])
C0027051 (UMLS CUI [5,7])
C0001779 (UMLS CUI [5,8])
C1512693 (UMLS CUI [6,1])
C0009932 (UMLS CUI [6,2])
C0021430 (UMLS CUI [6,3])
C0470187 (UMLS CUI [6,4])
C0444245 (UMLS CUI [6,5])
C0470187 (UMLS CUI [6,6])
C1511726 (UMLS CUI [6,7])
C1441506 (UMLS CUI [6,8])
C3176199 (UMLS CUI [6,9])
C0001779 (UMLS CUI [6,10])
C0680251 (UMLS CUI [7,1])
C0007222 (UMLS CUI [7,2])
C0680251 (UMLS CUI [8,1])
C0681906 (UMLS CUI [8,2])
C0027051 (UMLS CUI [8,3])
C0332288 (UMLS CUI [8,4])
C0011900 (UMLS CUI [8,5])
*LDL Cholesterol (LDL):* Within each of two ethnic groups (whites and blacks), selection of 100 participants with extremely low LDL and 100 participants with extremely high LDL, after adjustment for age, sex, lipid medication status. *Inclusion* requires consent and available DNA, and presence of the following variables: race, sex, LDL measurement (baseline and any additional), age at LDL measurement, lipid-lowering medication status. *Exclusion*: not being sequenced for other phenotypes.
Item
*LDL Cholesterol (LDL):* Within each of two ethnic groups (whites and blacks), selection of 100 participants with extremely low LDL and 100 participants with extremely high LDL, after adjustment for age, sex, lipid medication status. *Inclusion* requires consent and available DNA, and presence of the following variables: race, sex, LDL measurement (baseline and any additional), age at LDL measurement, lipid-lowering medication status. *Exclusion*: not being sequenced for other phenotypes.
boolean
C0085756 (UMLS CUI [1,1])
C0853085 (UMLS CUI [1,2])
C0456081 (UMLS CUI [1,3])
C0001779 (UMLS CUI [1,4])
C0079399 (UMLS CUI [1,5])
C0585943 (UMLS CUI [1,6])
C0043157 (UMLS CUI [2,1])
C0853085 (UMLS CUI [2,2])
C0456081 (UMLS CUI [2,3])
C0001779 (UMLS CUI [2,4])
C0079399 (UMLS CUI [2,5])
C0585943 (UMLS CUI [2,6])
C0085756 (UMLS CUI [3,1])
C4747855 (UMLS CUI [3,2])
C0456081 (UMLS CUI [3,3])
C0001779 (UMLS CUI [3,4])
C0079399 (UMLS CUI [3,5])
C0585943 (UMLS CUI [3,6])
C0043157 (UMLS CUI [4,1])
C4747855 (UMLS CUI [4,2])
C0456081 (UMLS CUI [4,3])
C0001779 (UMLS CUI [4,4])
C0079399 (UMLS CUI [4,5])
C0585943 (UMLS CUI [4,6])
C1512693 (UMLS CUI [5,1])
C0021430 (UMLS CUI [5,2])
C0585943 (UMLS CUI [5,3])
C1533716 (UMLS CUI [5,4])
C0079399 (UMLS CUI [5,5])
C0001779 (UMLS CUI [5,6])
C0428474 (UMLS CUI [5,7])
C0680251 (UMLS CUI [6,1])
C1298908 (UMLS CUI [6,2])
C1328887 (UMLS CUI [6,3])
*Blood Pressure (BP):* Within each of two ethnic groups (whites and blacks), selection of 200 participants with extremely low residual systolic and diastolic blood pressure and 200 participants with extremely high residual systolic and diastolic blood pressure, after adjustment for age, sex, medication status and BMI. *Inclusion* requires consent and available DNA, and presence of the following variables: race, sex, systolic blood pressure (SBP), diastolic blood pressure (DBP), age, hypertension medication status and BMI. *Exclusion* of participants (or data) with age > 69 yr, prevalent MI, heart failure or BMI > 4SD at any exam but only for that exam (for those participants with multiple measurements); for selection of extreme low BP individuals, exclude those individuals who are on antihypertensive treatment or who are unknown to be on antihypertensive treatment.
Item
*Blood Pressure (BP):* Within each of two ethnic groups (whites and blacks), selection of 200 participants with extremely low residual systolic and diastolic blood pressure and 200 participants with extremely high residual systolic and diastolic blood pressure, after adjustment for age, sex, medication status and BMI. *Inclusion* requires consent and available DNA, and presence of the following variables: race, sex, systolic blood pressure (SBP), diastolic blood pressure (DBP), age, hypertension medication status and BMI. *Exclusion* of participants (or data) with age > 69 yr, prevalent MI, heart failure or BMI > 4SD at any exam but only for that exam (for those participants with multiple measurements); for selection of extreme low BP individuals, exclude those individuals who are on antihypertensive treatment or who are unknown to be on antihypertensive treatment.
boolean
C0085756 (UMLS CUI [1,1])
C0205251 (UMLS CUI [1,2])
C2704328 (UMLS CUI [1,3])
C0456081 (UMLS CUI [1,4])
C0001779 (UMLS CUI [1,5])
C0079399 (UMLS CUI [1,6])
C0585941 (UMLS CUI [1,7])
C1305855 (UMLS CUI [1,8])
C0043157 (UMLS CUI [2,1])
C0205251 (UMLS CUI [2,2])
C0456081 (UMLS CUI [2,3])
C0001779 (UMLS CUI [2,4])
C0079399 (UMLS CUI [2,5])
C0585941 (UMLS CUI [2,6])
C1305855 (UMLS CUI [2,7])
C0085756 (UMLS CUI [3,1])
C2704328 (UMLS CUI [3,2])
C0456081 (UMLS CUI [3,3])
C0001779 (UMLS CUI [3,4])
C0079399 (UMLS CUI [3,5])
C0585941 (UMLS CUI [3,6])
C1305855 (UMLS CUI [3,7])
C0043157 (UMLS CUI [4,1])
C0205250 (UMLS CUI [4,2])
C2704328 (UMLS CUI [4,3])
C0456081 (UMLS CUI [4,4])
C0001779 (UMLS CUI [4,5])
C0079399 (UMLS CUI [4,6])
C0585941 (UMLS CUI [4,7])
C1305855 (UMLS CUI [4,8])
C1512693 (UMLS CUI [5,1])
C0021430 (UMLS CUI [5,2])
C0012854 (UMLS CUI [5,3])
C1533716 (UMLS CUI [5,4])
C0034510 (UMLS CUI [5,5])
C0001779 (UMLS CUI [5,6])
C0428883 (UMLS CUI [5,7])
C0871470 (UMLS CUI [5,8])
C0585941 (UMLS CUI [5,9])
C1305855 (UMLS CUI [5,10])
C0680251 (UMLS CUI [6,1])
C0001779 (UMLS CUI [6,2])
C1298908 (UMLS CUI [6,3])
C1328887 (UMLS CUI [6,4])
C0027051 (UMLS CUI [6,5])
C0018801 (UMLS CUI [6,6])
C1305855 (UMLS CUI [6,7])
C0585941 (UMLS CUI [6,8])
*Ischemic Stroke (STROKE):* Within each of two ethnic groups (whites and blacks), selection of 250 participants with early onset (less than 65y) or positive family history of ischemic stroke. These cases will be compared with the deeply phenotyped reference sample. *Inclusion* requires consent and available DNA, and available documentation that the stroke is ischemic and has been adjudicated with characteristics of likely etiology (subtyping). Required variables include race, sex, family history of stroke, and age at stroke. Only participants with a positive family history of stroke and/or diagnosed prior to 65 y will be included. Stroke subtypes included for study include small vessel occlusion/lacunar and large artery atherosclerosis/atherosclerotic (more specifically, non-lacunar and non-cardioembolic). *Exclusion* of participants includes those with absence of subtyping (based on TOAST, SHEP or equivalent criteria). Participants will be excluded if unknown or undefined stroke subtype; cardioembolic stroke subtype is also excluded.
Item
*Ischemic Stroke (STROKE):* Within each of two ethnic groups (whites and blacks), selection of 250 participants with early onset (less than 65y) or positive family history of ischemic stroke. These cases will be compared with the deeply phenotyped reference sample. *Inclusion* requires consent and available DNA, and available documentation that the stroke is ischemic and has been adjudicated with characteristics of likely etiology (subtyping). Required variables include race, sex, family history of stroke, and age at stroke. Only participants with a positive family history of stroke and/or diagnosed prior to 65 y will be included. Stroke subtypes included for study include small vessel occlusion/lacunar and large artery atherosclerosis/atherosclerotic (more specifically, non-lacunar and non-cardioembolic). *Exclusion* of participants includes those with absence of subtyping (based on TOAST, SHEP or equivalent criteria). Participants will be excluded if unknown or undefined stroke subtype; cardioembolic stroke subtype is also excluded.
boolean
C0085756 (UMLS CUI [1,1])
C0814120 (UMLS CUI [1,2])
C0948008 (UMLS CUI [1,3])
C1261367 (UMLS CUI [1,4])
C0043157 (UMLS CUI [2,1])
C0814120 (UMLS CUI [2,2])
C0948008 (UMLS CUI [2,3])
C1261367 (UMLS CUI [2,4])
C1512693 (UMLS CUI [3,1])
C0021430 (UMLS CUI [3,2])
C0012854 (UMLS CUI [3,3])
C1533716 (UMLS CUI [3,4])
C0948008 (UMLS CUI [3,5])
C1261367 (UMLS CUI [3,6])
C0001779 (UMLS CUI [3,7])
C0079399 (UMLS CUI [3,8])
C4533393 (UMLS CUI [3,9])
C0680251 (UMLS CUI [4,1])
C1298908 (UMLS CUI [4,2])
C1328887 (UMLS CUI [4,3])
C4533393 (UMLS CUI [4,4])
C0205427 (UMLS CUI [4,5])
C0439673 (UMLS CUI [4,6])
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