Elig.phs000390.v1.p1.1
Item
Subjects included in this project are unrelated random US Caucasian adults.
boolean
C0043157 (UMLS CUI [1,1])
C1546988 (UMLS CUI [1,2])
Elig.phs000390.v1.p1.2
Item
Individuals must meet the following inclusion criteria to be eligible to participate in the study:
boolean
C1512693 (UMLS CUI [1,1])
Elig.phs000390.v1.p1.3
Item
Caucasians of European origin;
boolean
C0043157 (UMLS CUI [1,1])
C0425355 (UMLS CUI [1,2])
Elig.phs000390.v1.p1.4
Item
Be ≥18 years of age (to ensure peak bone mass is attained);
boolean
C0001779 (UMLS CUI [1,1])
Elig.phs000390.v1.p1.5
Item
Be willing to participate in the study and attend exam for bone densitometry and blood draw.
boolean
C0600109 (UMLS CUI [1,1])
C1999232 (UMLS CUI [1,2])
C4321457 (UMLS CUI [1,3])
C0920149 (UMLS CUI [1,4])
C0190979 (UMLS CUI [1,5])
Elig.phs000390.v1.p1.6
Item
We adopted the following exclusion criteria to minimize nongenetic influence on bone mass variation so as to empirically enhance the importance of individual genetic factors for bone mass:
boolean
C0680251 (UMLS CUI [1,1])
C4054723 (UMLS CUI [1,2])
C0005938 (UMLS CUI [1,3])
Elig.phs000390.v1.p1.7
Item
Female subjects who are, or could be pregnant;
boolean
C0032961 (UMLS CUI [1,1])
Elig.phs000390.v1.p1.8
Item
Female subjects who have had an oophorectomy;
boolean
C0279787 (UMLS CUI [1,1])
Elig.phs000390.v1.p1.9
Item
Serious residuals from cerebral vascular disease;
boolean
C1609982 (UMLS CUI [1,1])
C0006104 (UMLS CUI [1,2])
C0042373 (UMLS CUI [1,3])
Elig.phs000390.v1.p1.10
Item
Diabetes mellitus, except for easily controlled, non insulin dependent diabetes mellitus;
boolean
C0011849 (UMLS CUI [1,1])
C0332300 (UMLS CUI [2,1])
C2911690 (UMLS CUI [2,2])
C0011860 (UMLS CUI [2,3])
Elig.phs000390.v1.p1.11
Item
Chronic renal disease manifest by serum creatinine >1.9 mg/dl;
boolean
C0201976 (UMLS CUI [1,1])
C1561643 (UMLS CUI [1,2])
Elig.phs000390.v1.p1.12
Item
Chronic liver disease or alcoholism;
boolean
C0341439 (UMLS CUI [1,1])
C0038586 (UMLS CUI [2,1])
C0001973 (UMLS CUI [2,2])
Elig.phs000390.v1.p1.13
Item
Significant chronic lung disease;
boolean
C0746102 (UMLS CUI [1,1])
Elig.phs000390.v1.p1.14
Item
Corticosteroid therapy at pharmacologic levels for more than 6 months duration;
boolean
C0149783 (UMLS CUI [1,1])
C4071833 (UMLS CUI [1,2])
Elig.phs000390.v1.p1.15
Item
Treatment with anticonvulsant therapy for more than 6 months duration;
boolean
C4071833 (UMLS CUI [1,1])
C0521306 (UMLS CUI [1,2])
Elig.phs000390.v1.p1.16
Item
Evidence of other metabolic or inherited bone disease such as hyper- or hypoparathyroidism, Paget's disease, osteomalacia, osteogenisis imperfecta or others;
boolean
C0005944 (UMLS CUI [1,1])
C0019247 (UMLS CUI [1,2])
C0020502 (UMLS CUI [1,3])
C0020626 (UMLS CUI [1,4])
C1368019 (UMLS CUI [1,5])
C0029442 (UMLS CUI [1,6])
C0029434 (UMLS CUI [1,7])
Elig.phs000390.v1.p1.17
Item
Rheumatoid arthritis or collagen disease;
boolean
C0003873 (UMLS CUI [1,1])
C0009326 (UMLS CUI [1,2])
Elig.phs000390.v1.p1.18
Item
Recent major gastrointestinal disease (within the past year) such as peptic ulcer, malabsorption, chronic ulcerative colitis, regional enteritis, or any significant chronic diarrhea state;
boolean
C0017178 (UMLS CUI [1,1])
C0030920 (UMLS CUI [1,2])
C0009324 (UMLS CUI [1,3])
C0678202 (UMLS CUI [1,4])
C0401151 (UMLS CUI [1,5])
Elig.phs000390.v1.p1.19
Item
Significant disease of any endocrine organ that would affect BMD;
boolean
C1397856 (UMLS CUI [1,1])
C0005938 (UMLS CUI [1,2])
Elig.phs000390.v1.p1.20
Item
Hyperthyroidism;
boolean
C0020550 (UMLS CUI [1,1])
Elig.phs000390.v1.p1.21
Item
Any neurologic or musculoskeletal condition that would be a non-genetic cause of low BMD;
boolean
C0026857 (UMLS CUI [1,1])
C0027765 (UMLS CUI [1,2])
C0205251 (UMLS CUI [1,3])
C0005938 (UMLS CUI [1,4])
Elig.phs000390.v1.p1.22
Item
Any disease, treatment (e.g., bisphosphonates, evista and teraparatide), or condition that would be an apparent non-genetic cause for BMD variation.
boolean
C0012634 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])
C0348080 (UMLS CUI [1,3])
C0005938 (UMLS CUI [1,4])
C0443172 (UMLS CUI [1,5])