Elig.phs000401.v1.p1.1
Item
The following are the inclusion/exclusion criteria across the HeartGO consortia phenotype groups; each HeartGO cohort was represented in one or more of these phenotype groups.
boolean
C0680251 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
Elig.phs000401.v1.p1.2
Item
*Early-Onset MI (EOMI):* Within each of two ethnic groups (whites and blacks), selection of 200 cases with early-onset myocardial infarction (MI) and 200 participants with absence of MI despite extreme Framingham Risk Score (FRS). *Inclusion* of individuals with consent and DNA available; for cases, the participant data includes study adjudication of reported MI and onset prior to age 45y (men) or 55y (women); for comparison (non-MI) participants, there must be data to calculate the Framingham Risk Score (FRS; age, sex, total cholesterol, HDL cholesterol, smoking status, systolic blood pressure, blood pressure medications), with age greater than 50y (men) or 60y (women). *Exclusion* of participants with prevalent or incident CVD; cases with self-reported MI but without adjudication of clinical data.
boolean
C4014367 (UMLS CUI [1,1])
C0015031 (UMLS CUI [2,1])
C0085756 (UMLS CUI [2,2])
C0043157 (UMLS CUI [2,3])
C4014367 (UMLS CUI [3,1])
C0332197 (UMLS CUI [4,1])
C4014367 (UMLS CUI [4,2])
C5442395 (UMLS CUI [4,3])
C1512693 (UMLS CUI [5,1])
C1698493 (UMLS CUI [5,2])
C0021430 (UMLS CUI [5,3])
C0012854 (UMLS CUI [5,4])
C0027051 (UMLS CUI [5,5])
C0206132 (UMLS CUI [5,6])
C1512693 (UMLS CUI [6,1])
C0009932 (UMLS CUI [6,2])
C5442395 (UMLS CUI [6,3])
C0001779 (UMLS CUI [6,4])
C0079399 (UMLS CUI [6,5])
C0543421 (UMLS CUI [6,6])
C0023822 (UMLS CUI [6,7])
C1519386 (UMLS CUI [6,8])
C0871470 (UMLS CUI [6,9])
C2926598 (UMLS CUI [6,10])
C0680251 (UMLS CUI [7,1])
C0007222 (UMLS CUI [7,2])
C2700446 (UMLS CUI [7,3])
C0027051 (UMLS CUI [7,4])
Elig.phs000401.v1.p1.3
Item
*LDL Cholesterol (LDL):* Within each of two ethnic groups (whites and blacks), selection of 100 participants with extremely low LDL and 100 participants with extremely high LDL, after adjustment for age, sex, lipid medication status. *Inclusion* requires consent and available DNA, and presence of the following variables: race, sex, LDL measurement (baseline and any additional), age at LDL measurement, lipid-lowering medication status. *Exclusion*: not being sequenced for other phenotypes.
boolean
C0023824 (UMLS CUI [1,1])
C0205250 (UMLS CUI [1,2])
C0205251 (UMLS CUI [1,3])
C0001779 (UMLS CUI [1,4])
C0079399 (UMLS CUI [1,5])
C0585943 (UMLS CUI [1,6])
C1512693 (UMLS CUI [2,1])
C0021430 (UMLS CUI [2,2])
C0012854 (UMLS CUI [2,3])
C0034510 (UMLS CUI [2,4])
C0079399 (UMLS CUI [2,5])
C0428474 (UMLS CUI [2,6])
C0585943 (UMLS CUI [2,7])
C0680251 (UMLS CUI [3,1])
C1298908 (UMLS CUI [3,2])
C1561491 (UMLS CUI [3,3])
Elig.phs000401.v1.p1.4
Item
*Blood Pressure (BP):* Within each of two ethnic groups (whites and blacks), selection of 200 participants with extremely low residual systolic and diastolic blood pressure and 200 participants with extremely high residual systolic and diastolic blood pressure, after adjustment for age, sex, medication status and BMI. *Inclusion* requires consent and available DNA, and presence of the following variables: race, sex, systolic blood pressure (SBP), diastolic blood pressure (DBP), age, hypertension medication status and BMI. *Exclusion* of participants (or data) with age > 69 yr, prevalent MI, heart failure or BMI > 4SD at any exam but only for that exam (for those participants with multiple measurements); for selection of extreme low BP individuals, exclude those individuals who are on antihypertensive treatment or who are unknown to be on antihypertensive treatment.
boolean
C0005823 (UMLS CUI [1,1])
C0020649 (UMLS CUI [1,2])
C3843080 (UMLS CUI [1,3])
C0001779 (UMLS CUI [1,4])
C0079399 (UMLS CUI [1,5])
C5447395 (UMLS CUI [1,6])
C1305855 (UMLS CUI [1,7])
C1512693 (UMLS CUI [2,1])
C0021430 (UMLS CUI [2,2])
C0012854 (UMLS CUI [2,3])
C0034510 (UMLS CUI [2,4])
C0079399 (UMLS CUI [2,5])
C0871470 (UMLS CUI [2,6])
C0428883 (UMLS CUI [2,7])
C0001779 (UMLS CUI [2,8])
C0684167 (UMLS CUI [2,9])
C1305855 (UMLS CUI [2,10])
C0680251 (UMLS CUI [3,1])
C0027051 (UMLS CUI [3,2])
C0018801 (UMLS CUI [3,3])
C1305855 (UMLS CUI [3,4])
C0680251 (UMLS CUI [4,1])
C0020649 (UMLS CUI [4,2])
C0684167 (UMLS CUI [4,3])
Elig.phs000401.v1.p1.5
Item
*Ischemic Stroke (STROKE):* Within each of two ethnic groups (whites and blacks), selection of 250 participants with early onset (less than 65y) or positive family history of ischemic stroke. These cases will be compared with the deeply phenotyped reference sample. *Inclusion* requires consent and available DNA, and available documentation that the stroke is ischemic and has been adjudicated with characteristics of likely etiology (subtyping). Required variables include race, sex, family history of stroke, and age at stroke. Only participants with a positive family history of stroke and/or diagnosed prior to 65 y will be included. Stroke subtypes included for study include small vessel occlusion/lacunar and large artery atherosclerosis/atherosclerotic (more specifically, non-lacunar and non-cardioembolic). *Exclusion* of participants includes those with absence of subtyping (based on TOAST, SHEP or equivalent criteria). Participants will be excluded if unknown or undefined stroke subtype; cardioembolic stroke subtype is also excluded.
boolean
C0948008 (UMLS CUI [1,1])
C0814120 (UMLS CUI [1,2])
C1446409 (UMLS CUI [1,3])
C0241889 (UMLS CUI [1,4])
C0680399 (UMLS CUI [2,1])
C0031437 (UMLS CUI [2,2])
C1512693 (UMLS CUI [3,1])
C0021430 (UMLS CUI [3,2])
C0012854 (UMLS CUI [3,3])
C0948008 (UMLS CUI [3,4])
C1314792 (UMLS CUI [3,5])
C0034510 (UMLS CUI [3,6])
C0079399 (UMLS CUI [3,7])
C0241889 (UMLS CUI [3,8])
C0206132 (UMLS CUI [3,9])
C1512693 (UMLS CUI [4,1])
C0038454 (UMLS CUI [4,2])
C0449560 (UMLS CUI [4,3])
C2733158 (UMLS CUI [4,4])
C0333559 (UMLS CUI [4,5])
C0333482 (UMLS CUI [4,6])
C0680251 (UMLS CUI [5,1])
C0332197 (UMLS CUI [5,2])
C0449560 (UMLS CUI [5,3])
C1531624 (UMLS CUI [5,4])