Elig.phs000276.v2.p1.1
Item
A detailed description of design of the NFBC1966 study can be found at: Sabatti C, Service SK, Hartikainen AL, Pouta A, Ripatti S, Brodsky J, Jones CG, Zaitlen NA, Varilo T, Kaakinen M, Sovio U, Ruokonen A, Laitinen J, Jakkula E, Coin L, Hoggart C, Collins A, Turunen H, Gabriel S, Elliot P, McCarthy MI, Daly MJ, Järvelin MR, Freimer NB, Peltonen L. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet. 2009 Jan;41(1):35-46, PMID: 19060910.
boolean
C1522508 (UMLS CUI [1,1])
C4687732 (UMLS CUI [1,2])
Elig.phs000276.v2.p1.2
Item
Specific exclusion criteria used in the above analyses include: Subjects were excluded from analysis of specific phenotypes on the basis of criteria that were established separately for each phenotype. Individuals were excluded from analysis of lipid phenotypes (TG, HDL, LDL) if the blood sample was not collected after fasting, or if they were diabetic. Individuals were excluded from analysis of GLU and INS if the blood sample was non-fasting, if they were diabetic, on diabetic medication, pregnant, or if their glucose/insulin measurement (after correction for sex, oral contraceptive use, and pregnancy status) was in excess of three standard deviations from the mean. Individuals were excluded from analysis of BMI if their weight was self-reported, or if they were pregnant. No exclusion criteria were applied to CRP or to SBP/DBP.
boolean
C0680251 (UMLS CUI [1,1])
C0005834 (UMLS CUI [2,1])
C0523744 (UMLS CUI [2,2])
C1298908 (UMLS CUI [2,3])
C0015663 (UMLS CUI [2,4])
C0005834 (UMLS CUI [3,1])
C0523744 (UMLS CUI [3,2])
C0241863 (UMLS CUI [3,3])
C0005834 (UMLS CUI [4,1])
C1337112 (UMLS CUI [4,2])
C0017725 (UMLS CUI [4,3])
C1298908 (UMLS CUI [4,4])
C0015663 (UMLS CUI [4,5])
C0005834 (UMLS CUI [5,1])
C1337112 (UMLS CUI [5,2])
C0017725 (UMLS CUI [5,3])
C0241863 (UMLS CUI [5,4])
C0005834 (UMLS CUI [6,1])
C1337112 (UMLS CUI [6,2])
C0017725 (UMLS CUI [6,3])
C0935929 (UMLS CUI [6,4])
C0005834 (UMLS CUI [7,1])
C1337112 (UMLS CUI [7,2])
C0017725 (UMLS CUI [7,3])
C0032961 (UMLS CUI [7,4])
C0005834 (UMLS CUI [8,1])
C1337112 (UMLS CUI [8,2])
C0017725 (UMLS CUI [8,3])
C0202042 (UMLS CUI [8,4])
C0202098 (UMLS CUI [8,5])
C0442802 (UMLS CUI [8,6])
C0936012 (UMLS CUI [9,1])
C1305855 (UMLS CUI [9,2])
C5191673 (UMLS CUI [9,3])
C0032961 (UMLS CUI [9,4])
Elig.phs000276.v2.p1.3
Item
Any individual with genotyping call rates <95% was excluded from analysis. Subjects who were discrepant between their reported sex and the sex determined from the X Chromosome were excluded from analysis. We employed the identity-by-descent (IBD) analysis option of PLINK (Purcell et al. 2007, PMID: 17701901) to determine possible relatedness among our sample subjects, and to identify sample duplications and sample contamination (the latter identified as subjects who appeared to be related to nearly everyone in the sample). If the sample duplication issue could not be resolved by external means, both samples were excluded. All apparently contaminated samples were excluded. Individuals related at the level of half-sibs or closer were identified with the IBD analysis and one subject excluded from each pair (the subject with less complete genotyping). Subsequent to this overall exclusion, subjects may be excluded from analysis of specific phenotypes as detailed above.
boolean
C0680251 (UMLS CUI [1,1])
C3846158 (UMLS CUI [2,1])
C1290905 (UMLS CUI [3,1])
C0079399 (UMLS CUI [3,2])
C2700446 (UMLS CUI [3,3])
C0079399 (UMLS CUI [3,4])
C0521095 (UMLS CUI [3,5])
C0200867 (UMLS CUI [3,6])
C2347026 (UMLS CUI [4,1])
C0332597 (UMLS CUI [4,2])
C0205279 (UMLS CUI [5,1])
C2347026 (UMLS CUI [5,2])
C0015608 (UMLS CUI [6,1])
C0337505 (UMLS CUI [6,2])
C0015608 (UMLS CUI [7,1])
C1517194 (UMLS CUI [7,2])