Elig.phs000293.v1.p1.1
Item
**Inclusion Criteria for Phenotype of IA - Definition of Affected Family Member**
boolean
C1512693 (UMLS CUI [1,1])
C0031437 (UMLS CUI [1,2])
C0751003 (UMLS CUI [1,3])
C1512693 (UMLS CUI [2,1])
C0241889 (UMLS CUI [2,2])
Elig.phs000293.v1.p1.2
Item
Ruptured or unruptured IA as demonstrated by intra-arterial cerebral angiography, surgery, or autopsy.
boolean
C0751003 (UMLS CUI [1,1])
Elig.phs000293.v1.p1.3
Item
Patients with a severe non-traumatic SAH, who do not undergo cerebral angiography to document their aneurysm because of early mortality or vegetative condition, will be designated as SAH due to presumed IA rupture. Massive non-traumatic SAH that results in early death is almost always due to rupture of an IA. These persons will be included as an affected case if the following conditions are met: a) non-traumatic abrupt onset of severe headache or altered level of consciousness that is associated with blood in the subarachnoid space on CT or at autopsy, b) widespread SAH by CT or autopsy, not limited to the interpeduncular cistern, c) no evidence of a structural cause of SAH other than IA by CT or MR brain imaging.
boolean
C3862768 (UMLS CUI [1,1])
C1298908 (UMLS CUI [1,2])
C1658602 (UMLS CUI [1,3])
C3846158 (UMLS CUI [2,1])
Elig.phs000293.v1.p1.4
Item
**Exclusion Criteria**
boolean
C0680251 (UMLS CUI [1,1])
Elig.phs000293.v1.p1.5
Item
Fusiform-shaped unruptured IA of a major intracranial trunk artery or IA which is part of an arteriovenous malformation.
boolean
C0155730 (UMLS CUI [1,1])
C0332493 (UMLS CUI [1,2])
C0917804 (UMLS CUI [1,3])
C0555939 (UMLS CUI [1,4])
Elig.phs000293.v1.p1.6
Item
Family history of polycystic kidney disease, Ehlers Danlos Syndrome, Marfan's Syndrome, fibromuscular dysplasia, or Moya-Moya syndrome (abnormal proliferation of small intracranial vessels that results from primary occlusion of intracranial arteries and can lead to SAH and ICH).
boolean
C0241889 (UMLS CUI [1,1])
C0022680 (UMLS CUI [1,2])
C0241889 (UMLS CUI [2,1])
C0013720 (UMLS CUI [2,2])
C0241889 (UMLS CUI [3,1])
C0024796 (UMLS CUI [3,2])
C0241889 (UMLS CUI [4,1])
C1847887 (UMLS CUI [4,2])
C0241889 (UMLS CUI [5,1])
C0016052 (UMLS CUI [5,2])
Elig.phs000293.v1.p1.7
Item
Failure to obtain informed consent from patient and family.
boolean
C0021430 (UMLS CUI [1,1])
C0332268 (UMLS CUI [1,2])