Exclusion Criteria
Have had a clinically significant history of cardiac disease or presence of active cardiac disease within the year prior to inclusion in the study, including myocardial infarction, clinically significant arrhythmia, unstable angina, moderate to severe congestive heart failure, coronary artery bypass surgery, or angioplasty. or is expected to require coronary artery bypass surgery or angioplasty during the course of the study.
boolean
Have clinical signs or symptoms of liver disease, acute or chronic hepatitis.
boolean
Have a history of renal transplantation or are currently receiving renal dialysis.
boolean
Have active or untreated malignancy, or have been in remission from clinically significant malignancy (other than basal cell or squamous cell skin cancer, in situ carcinomas of the cervix, or in situ prostate cancer) for less than 5 years.
boolean
Have had > 3 episodes of major hypoglycemia within 6 months prior to screening.
boolean
Have any contraindication for the oral antidiabetic agent which they use.
boolean
Have a known allergy or hypersensitivity to insulin glargine, exenatide once weekly, or excipients contained in these agents.
boolean
Are known to have active proliferative retinopathy.
boolean
Have been treated with drugs that promote weight loss (e.g., Xenical [orlistat], Meridia [sibutramine], Acomplia [rimonabant], Acutrim [phenylpropanolamine], or similar over-the-counter medications) within 3 months of screening.
boolean
Have been treated for longer than 2 weeks with any of the following excluded medications within 3 months prior to screening:
boolean
Insulin
boolean
Thiazolidinediones (e.g., Actos [pioglitazone] or Avandia [rosiglitazone])
boolean
Alpha-glucosidase inhibitors (e.g., Glyset [miglitol] or Precose [acarbose])
boolean
Meglitinides (e.g., Prandin [repaglinide] or Starlix [nateglinide]).
boolean
Byetta (exenatide BID formulation)
boolean
Dipeptidyl peptidase (DPP)-4 inhibitors (e.g., Januvia [sitagliptin], Galvus [vildagliptin])
boolean
Symlin (pramlintide acetate).
boolean
Have had an organ transplant.
boolean
Have donated blood within 30 days of screening.
boolean
Have previously completed or withdrawn from this study or any other study investigating exenatide once weekly.
boolean
Have received treatment within the last 30 days with a drug that has not received regulatory approval for any indication at the time of study entry.
boolean
Are currently enrolled in any other clinical study.
boolean