Elig.phs000018.v2.p1.1
Item
*Inclusion criteria*
boolean
C1512693 (UMLS CUI [1,1])
Elig.phs000018.v2.p1.2
Item
Probands for this data collection must have type 1 diabetes and either presence or absence of diabetic nephropathy according to the following definitions: Type 1 diabetes is diagnosed if:
boolean
C1512693 (UMLS CUI [1,1])
C0011849 (UMLS CUI [1,2])
C0441729 (UMLS CUI [1,3])
C0011881 (UMLS CUI [1,4])
C1512693 (UMLS CUI [2,1])
C0011849 (UMLS CUI [2,2])
C0441729 (UMLS CUI [2,3])
C0332288 (UMLS CUI [2,4])
C0011881 (UMLS CUI [2,5])
Elig.phs000018.v2.p1.3
Item
Subject had diabetes diagnosed before age 31
boolean
C0011849 (UMLS CUI [1,1])
C1828181 (UMLS CUI [1,2])
Elig.phs000018.v2.p1.4
Item
Treatment with insulin was instituted within one year of diagnosis
boolean
C0332162 (UMLS CUI [1,1])
C0745343 (UMLS CUI [1,2])
C4082117 (UMLS CUI [1,3])
C0687676 (UMLS CUI [1,4])
C0011849 (UMLS CUI [1,5])
Elig.phs000018.v2.p1.5
Item
Treatment with insulin has been uninterrupted since diagnosis Presence of diabetic nephropathy is diagnosed if:
boolean
C0011849 (UMLS CUI [1,1])
C0745343 (UMLS CUI [1,2])
C3843614 (UMLS CUI [1,3])
C1711239 (UMLS CUI [1,4])
C0011900 (UMLS CUI [1,5])
Elig.phs000018.v2.p1.6
Item
Subject with diabetes for at least 10 years has persistent proteinuria or ESRD (not due to condition other than diabetes). Persistent proteinuria is defined as at least 2 of 3 tests positive for albuminuria (at least 1 month apart), i.e., dipstick (Albustix or Multistix) at least 1+ or ACR value exceeding 300 μg albumin/mg of urine creatinine. Absence of diabetic nephropathy is diagnosed if:
boolean
C0011849 (UMLS CUI [1,1])
C3844145 (UMLS CUI [1,2])
C0033687 (UMLS CUI [1,3])
C0205322 (UMLS CUI [1,4])
C0011849 (UMLS CUI [2,1])
C3844145 (UMLS CUI [2,2])
C0022661 (UMLS CUI [2,3])
Elig.phs000018.v2.p1.7
Item
Subject has persistent normoalbuminuria despite duration of type 1 diabetes for at least 15 years and has never been treated with ACE inhibitors. Persistent normoalbuminuria is defined as at least 2 of 3 ACR measurements (at least 1 month apart) in random urine specimen being less than 20 μg of albumin/mg of creatinine. If 3 ACR measurements are needed, the highest must also be less than 40 μg of albumin/mg of creatinine.
boolean
C0011849 (UMLS CUI [1,1])
C0441729 (UMLS CUI [1,2])
C1948053 (UMLS CUI [1,3])
C5230927 (UMLS CUI [1,4])
C2003901 (UMLS CUI [1,5])
C0332293 (UMLS CUI [1,6])
C0003015 (UMLS CUI [1,7])
Elig.phs000018.v2.p1.8
Item
*Exclusion criteria*
boolean
C0680251 (UMLS CUI [1,1])
Elig.phs000018.v2.p1.9
Item
Individuals will be excluded from the study if they do not meet the inclusion criteria described above or if any of the following exclusion criteria are met: Unable or unwilling to give informed consent
boolean
C0680251 (UMLS CUI [1,1])
C0021430 (UMLS CUI [1,2])
C1299582 (UMLS CUI [1,3])
C0680251 (UMLS CUI [2,1])
C0021430 (UMLS CUI [2,2])
C0558080 (UMLS CUI [2,3])
Elig.phs000018.v2.p1.10
Item
Unable to communicate with staff
boolean
C0680251 (UMLS CUI [1,1])
C0566000 (UMLS CUI [1,2])
Elig.phs000018.v2.p1.11
Item
Major psychiatric disorder such as schizophrenia
boolean
C0680251 (UMLS CUI [1,1])
C0004936 (UMLS CUI [1,2])
C0205164 (UMLS CUI [1,3])
Elig.phs000018.v2.p1.12
Item
Exclusion in relation to medication
boolean
C0680251 (UMLS CUI [1,1])
C0013227 (UMLS CUI [1,2])
Elig.phs000018.v2.p1.13
Item
Any antihypertensive medication for controls
boolean
C0680251 (UMLS CUI [1,1])
C3274648 (UMLS CUI [1,2])
C0003364 (UMLS CUI [1,3])
Elig.phs000018.v2.p1.14
Item
Infectious disease
boolean
C0680251 (UMLS CUI [1,1])
C0009450 (UMLS CUI [1,2])
Elig.phs000018.v2.p1.15
Item
Self-reported HIV positivity
boolean
C0680251 (UMLS CUI [1,1])
C0019693 (UMLS CUI [1,2])
Elig.phs000018.v2.p1.16
Item
Active tuberculosis
boolean
C0680251 (UMLS CUI [1,1])
C0151332 (UMLS CUI [1,2])
Elig.phs000018.v2.p1.17
Item
Other kidney disease in cases
boolean
C0680251 (UMLS CUI [1,1])
C3274647 (UMLS CUI [1,2])
C0022658 (UMLS CUI [1,3])
C0205394 (UMLS CUI [1,4])
Elig.phs000018.v2.p1.18
Item
Alport syndrome
boolean
C0680251 (UMLS CUI [1,1])
C1567741 (UMLS CUI [1,2])
Elig.phs000018.v2.p1.19
Item
Analgesic nephropathy
boolean
C0680251 (UMLS CUI [1,1])
C0149938 (UMLS CUI [1,2])
Elig.phs000018.v2.p1.20
Item
Atheroembolic renal disease
boolean
C0680251 (UMLS CUI [1,1])
C0268792 (UMLS CUI [1,2])
Elig.phs000018.v2.p1.21
Item
Congenital nephrotic syndrome
boolean
C0680251 (UMLS CUI [1,1])
C3501848 (UMLS CUI [1,2])
Elig.phs000018.v2.p1.22
Item
Focal segmental glomerulosclerosis (FSGS)
boolean
C0680251 (UMLS CUI [1,1])
C0017668 (UMLS CUI [1,2])
Elig.phs000018.v2.p1.23
Item
Glomerulonephritis
boolean
C0680251 (UMLS CUI [1,1])
C0017658 (UMLS CUI [1,2])
Elig.phs000018.v2.p1.24
Item
Goodpasture's syndrome
boolean
C0680251 (UMLS CUI [1,1])
C0403529 (UMLS CUI [1,2])
Elig.phs000018.v2.p1.25
Item
HIV nephropathy
boolean
C0680251 (UMLS CUI [1,1])
C0078911 (UMLS CUI [1,2])
Elig.phs000018.v2.p1.26
Item
IgM mesangial proliferative nephritis
boolean
C0680251 (UMLS CUI [1,1])
C0221238 (UMLS CUI [1,2])
C0020861 (UMLS CUI [1,3])
Elig.phs000018.v2.p1.27
Item
Lupus nephritis
boolean
C0680251 (UMLS CUI [1,1])
C0024143 (UMLS CUI [1,2])
Elig.phs000018.v2.p1.28
Item
Kidney cancer
boolean
C0680251 (UMLS CUI [1,1])
C0740457 (UMLS CUI [1,2])
Elig.phs000018.v2.p1.29
Item
IgA nephropathy
boolean
C0680251 (UMLS CUI [1,1])
C0017661 (UMLS CUI [1,2])
Elig.phs000018.v2.p1.30
Item
Polycystic kidney disease
boolean
C0680251 (UMLS CUI [1,1])
C0022680 (UMLS CUI [1,2])
Elig.phs000018.v2.p1.31
Item
Urinary tract infection (Note: infectious processes such as cystitis and urinary tract infections do not represent a permanent exclusion. Patients may be recontacted or asked to send a supplemental urine sample at a later date.)
boolean
C0680251 (UMLS CUI [1,1])
C0042029 (UMLS CUI [1,2])
Elig.phs000018.v2.p1.32
Item
Pregnant women (although they may be reconsidered 3 months after delivery)
boolean
C0680251 (UMLS CUI [1,1])
C0032961 (UMLS CUI [1,2])