Elig.phs000018.v2.p1.1
Item
*Inclusion criteria*
boolean
Elig.phs000018.v2.p1.2
Item
Probands for this data collection must have type 1 diabetes and either presence or absence of diabetic nephropathy according to the following definitions: Type 1 diabetes is diagnosed if:
boolean
Elig.phs000018.v2.p1.3
Item
Subject had diabetes diagnosed before age 31
boolean
Elig.phs000018.v2.p1.4
Item
Treatment with insulin was instituted within one year of diagnosis
boolean
Elig.phs000018.v2.p1.5
Item
Treatment with insulin has been uninterrupted since diagnosis Presence of diabetic nephropathy is diagnosed if:
boolean
Elig.phs000018.v2.p1.6
Item
Subject with diabetes for at least 10 years has persistent proteinuria or ESRD (not due to condition other than diabetes). Persistent proteinuria is defined as at least 2 of 3 tests positive for albuminuria (at least 1 month apart), i.e., dipstick (Albustix or Multistix) at least 1+ or ACR value exceeding 300 μg albumin/mg of urine creatinine. Absence of diabetic nephropathy is diagnosed if:
boolean
Elig.phs000018.v2.p1.7
Item
Subject has persistent normoalbuminuria despite duration of type 1 diabetes for at least 15 years and has never been treated with ACE inhibitors. Persistent normoalbuminuria is defined as at least 2 of 3 ACR measurements (at least 1 month apart) in random urine specimen being less than 20 μg of albumin/mg of creatinine. If 3 ACR measurements are needed, the highest must also be less than 40 μg of albumin/mg of creatinine.
boolean
Elig.phs000018.v2.p1.8
Item
*Exclusion criteria*
boolean
Elig.phs000018.v2.p1.9
Item
Individuals will be excluded from the study if they do not meet the inclusion criteria described above or if any of the following exclusion criteria are met: Unable or unwilling to give informed consent
boolean
Elig.phs000018.v2.p1.10
Item
Unable to communicate with staff
boolean
Elig.phs000018.v2.p1.11
Item
Major psychiatric disorder such as schizophrenia
boolean
Elig.phs000018.v2.p1.12
Item
Exclusion in relation to medication
boolean
Elig.phs000018.v2.p1.13
Item
Any antihypertensive medication for controls
boolean
Elig.phs000018.v2.p1.14
Item
Infectious disease
boolean
Elig.phs000018.v2.p1.15
Item
Self-reported HIV positivity
boolean
Elig.phs000018.v2.p1.16
Item
Active tuberculosis
boolean
Elig.phs000018.v2.p1.17
Item
Other kidney disease in cases
boolean
Elig.phs000018.v2.p1.18
Item
Alport syndrome
boolean
Elig.phs000018.v2.p1.19
Item
Analgesic nephropathy
boolean
Elig.phs000018.v2.p1.20
Item
Atheroembolic renal disease
boolean
Elig.phs000018.v2.p1.21
Item
Congenital nephrotic syndrome
boolean
Elig.phs000018.v2.p1.22
Item
Focal segmental glomerulosclerosis (FSGS)
boolean
Elig.phs000018.v2.p1.23
Item
Glomerulonephritis
boolean
Elig.phs000018.v2.p1.24
Item
Goodpasture's syndrome
boolean
Elig.phs000018.v2.p1.25
Item
HIV nephropathy
boolean
Elig.phs000018.v2.p1.26
Item
IgM mesangial proliferative nephritis
boolean
Elig.phs000018.v2.p1.27
Item
Lupus nephritis
boolean
Elig.phs000018.v2.p1.28
Item
Kidney cancer
boolean
Elig.phs000018.v2.p1.29
Item
IgA nephropathy
boolean
Elig.phs000018.v2.p1.30
Item
Polycystic kidney disease
boolean
Elig.phs000018.v2.p1.31
Item
Urinary tract infection (Note: infectious processes such as cystitis and urinary tract infections do not represent a permanent exclusion. Patients may be recontacted or asked to send a supplemental urine sample at a later date.)
boolean
Elig.phs000018.v2.p1.32
Item
Pregnant women (although they may be reconsidered 3 months after delivery)
boolean